ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2015
Defective autophagy through epg5 mutation results in failure to reduce germ plasm and mitochondria.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Population structure and selection signal analysis of indigenous sheep from the southern edge of the Taklamakan Desert.BMC genomics · 2024Article
- The constructive and destructive impact of autophagy on both genders' reproducibility, a comprehensive review.Autophagy · 2023Review
- Deficiency of cancer/testis antigen gene CT55 causes male infertility in humans and mice.Cell death and differentiation · 2023Article
- An antibody free approach to probe the presence of poly-ubiquitin chains onmicroPublication biology · 2023Article
- epg5 knockout leads to the impairment of reproductive success and courtship behaviour in a zebrafish model of autophagy-related diseases.Biomedical journal · 2022Article
- Autophagy core protein ATG5 is required for elongating spermatid development, sperm individualization and normal fertility in male mice.Autophagy · 2021Article
- Deciphering the autophagy regulatory network via single-cell transcriptome analysis reveals a requirement for autophagy homeostasis in spermatogenesis.Theranostics · 2021Article
- MitophAging: Mitophagy in Aging and Disease.Frontiers in cell and developmental biology · 2020Review
- TheAutophagy · 2019Article
- Methods to Determine the Role of Autophagy Proteins in C. elegans Aging.Methods in molecular biology (Clifton, N.J.) · 2019Article
- MicroRNA expression profiles in non‑epithelial ovarian tumors.International journal of oncology · 2018Article
- Article
- Non-parametric Survival Analysis of EPG5 Gene with Age at Onset of Alzheimer's Disease.Journal of molecular neuroscience : MN · 2016Article
- Intraflagellar transport protein IFT20 is essential for male fertility and spermiogenesis in mice.Molecular biology of the cell · 2016Article
- The germline-enriched Ppp1r36 promotes autophagy.Scientific reports · 2016Article
- Autophagy is increased in cryptorchid testis resulting in abnormal spermatozoa.Asian journal of andrologyArticle
- The impact of autophagy in spermiogenesis.Asian journal of andrologyArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 3 countries.
Funding
Abstract
Autophagy is an evolutionarily conserved catabolic process that transports cytoplasmic components to lysosomes for degradation. In addition to the canonical view of strict stress-response-induced autophagy, selectively programmed autophagy was recently reported in the context of gonad development of flies and worms, where autophagy seems to be necessary for clearance of germ plasm components. Similar functions have not been described in vertebrates. We used the medaka fish to study the role of autophagy in gonad formation and gametogenesis for the first time in a vertebrate organism for which the germ line is specified by germ plasm. Using a transgenic line deficient in the Ol-epg5 gene—a new critical component of the autophagy pathway—we show that such deficiency leads to an impaired autophagic flux, possibly attributed to compromised maturation or processing of the autophagosomes. Ol-epg5 deficiency correlates with selectively impaired spermatogenesis and low allele transmission rates of the mutant allele caused by failure of germ plasm and mitochondria clearance during the process of germ cell specification and in the adult gonads. The mouse epg-5 homolog is similarly expressed in the maturating and adult testes, suggesting an at least partially conserved function of this process during spermatogenesis in vertebrates.
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