ReviewClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2016
Neurophysiological biomarkers for Lewy body dementias.
Review in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07375771 (Interventional Study to Evaluate the Effectiveness of Transcranial Alternating Current Stimulation), which is not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Interventional Study to Evaluate the Effectiveness of Transcranial Alternating Current Stimulation (tACS) on Cognitive Performance in Patients With Lewy Body Dementia
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diagnostic utility of electrophysiological markers for early and differential diagnosis of Alzheimer's, Frontotemporal, and Lewy Body dementias: A systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Pooled it
- Consecutive sessions of transcranial direct current stimulation do not remediate visual hallucinations in Lewy body dementia: a randomised controlled trial.Alzheimer's research & therapy · 2019Trial
- Resting-State EEG Features of Cognitive Fluctuations Across the Lewy Body Disease Spectrum.Research square · 2026Article
- Linear predictive coding electroencephalography algorithms predict mortality in Parkinson's disease.Clinical parkinsonism & related disorders · 2025Article
- Differentiating Prodromal Dementia with Lewy Bodies from Prodromal Alzheimer's Disease: A Pragmatic Review for Clinicians.Neurology and therapy · 2024Article
- The high cost of care and limited evidence on cost-effective strategies for Lewy body dementia: systematic review of evidence.BJPsych open · 2024Review
- Article
- EEG-Derived Functional Connectivity Patterns Associated with Mild Cognitive Impairment in Parkinson's Disease.Behavioral sciences (Basel, Switzerland) · 2021Article
- The Role of EEG in the Diagnosis, Prognosis and Clinical Correlations of Dementia with Lewy Bodies-A Systematic Review.Diagnostics (Basel, Switzerland) · 2020Review
- Quantitative EEG as a biomarker in mild cognitive impairment with Lewy bodies.Alzheimer's research & therapy · 2020Article
- Burden of Disease and Current Management of Dementia with Lewy Bodies: A Literature Review.Neurology and therapy · 2019Review
- Dysfunctional brain dynamics and their origin in Lewy body dementia.Brain : a journal of neurology · 2019Article
- Insights into cognitive decline in spinocerebellar Ataxia type 2: a P300 event-related brain potential study.Cerebellum & ataxias · 2019Article
- Electroencephalographic derived network differences in Lewy body dementia compared to Alzheimer's disease patients.Scientific reports · 2018Article
- EEG Characteristics of Dementia With Lewy Bodies, Alzheimer's Disease and Mixed Pathology.Frontiers in aging neuroscience · 2018Article
- Cortical afferent inhibition abnormalities reveal cholinergic dysfunction in Parkinson's disease: a reappraisal.Journal of neural transmission (Vienna, Austria : 1996) · 2017Review
- Lewy Body Disorders.Neurologic clinics · 2017Review
- Random forest to differentiate dementia with Lewy bodies from Alzheimer's disease.Alzheimer's & dementia (Amsterdam, Netherlands) · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
objectiveLewy body dementias (LBD) include both dementia with Lewy bodies (DLB) and Parkinson's disease with dementia (PDD), and the differentiation of LBD from other neurodegenerative dementias can be difficult. Currently, there are few biomarkers which might assist early diagnosis, map onto LBD symptom severity, and provide metrics of treatment response. Traditionally, biomarkers in LBD have focussed on neuroimaging modalities; however, as biomarkers need to be simple, inexpensive and non-invasive, neurophysiological approaches might also be useful as LBD biomarkers.
methodsIn this review, we searched PubMED and PsycINFO databases in a semi-systematic manner in order to identify potential neurophysiological biomarkers in the LBDs.
resultsWe identified 1491 studies; of these, 37 studies specifically examined neurophysiological biomarkers in LBD patients. We found that there was substantial heterogeneity with respect to methodologies and patient cohorts.
conclusionGenerally, many of the findings have yet to be replicated, although preliminary findings reinforce the potential utility of approaches such as quantitative electroencephalography and motor cortical stimulation paradigms. SIGNIFICANCE: Various neurophysiological techniques have the potential to be useful biomarkers in the LBDs. We recommend that future studies focus on maximising the diagnostic specificity and sensitivity of the most promising neurophysiological biomarkers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.