ArticleHuman brain mapping2015
Altered inhibition-related frontolimbic connectivity in obsessive-compulsive disorder.
Article in Human brain mapping, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Exploring functional connectivity in large-scale brain networks in obsessive-compulsive disorder: a systematic review of EEG and fMRI studies.Cerebral cortex (New York, N.Y. : 1991) · 2024Pooled it
- Error Processing and Inhibitory Control in Obsessive-Compulsive Disorder: A Meta-analysis Using Statistical Parametric Maps.Biological psychiatry · 2019Pooled it
- Emotional Processing in Obsessive-Compulsive Disorder: A Systematic Review and Meta-analysis of 25 Functional Neuroimaging Studies.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2018Pooled it
- Mechanisms of cognitive-behavioral therapy for obsessive-compulsive disorder involve robust and extensive increases in brain network connectivity.Translational psychiatry · 2017Trial
- Preliminary examination of disgust learning as a potential OCD endophenotype.Journal of affective disorders · 2026Article
- Neurological activation during verbal fluency task and resting-state functional connectivity abnormalities in obsessive-compulsive disorder: a functional near-infrared spectroscopy study.Frontiers in psychiatry · 2024Article
- Long-range temporal correlations in resting state alpha oscillations in major depressive disorder and obsessive-compulsive disorder.Frontiers in neuroinformatics · 2024Article
- Abnormal focal segments in left uncinate fasciculus in adults with obsessive-compulsive disorder.Frontiers in psychiatry · 2023Article
- Atypical oscillatory dynamics during emotional face processing in paediatric obsessive-compulsive disorder with MEG.NeuroImage. Clinical · 2023Article
- Subcortical shape in pediatric and adult obsessive-compulsive disorder.Depression and anxiety · 2022Article
- Sustained attention induces altered effective connectivity of the ascending thalamo-cortical relay in obsessive-compulsive disorder.Frontiers in psychiatry · 2022Article
- Decreased left amygdala functional connectivity by cognitive-coping therapy in obsessive-compulsive disorder.Molecular psychiatry · 2021Article
- Dynamic Causal Modeling Self-Connectivity Findings in the Functional Magnetic Resonance Imaging Neuropsychiatric Literature.Frontiers in neuroscience · 2021Review
- Neurocognitive Endophenotypes of OCD.Current topics in behavioral neurosciences · 2021Article
- Disentangling Within- and Between-Person Effects During Response Inhibition in Obsessive-Compulsive Disorder.Frontiers in psychiatry · 2021Article
- Inhibition-Related Cortical Hypoconnectivity as a Candidate Vulnerability Marker for Obsessive-Compulsive Disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Article
- Stable inhibition-related inferior frontal hypoactivation and fronto-limbic hyperconnectivity in obsessive-compulsive disorder after concentrated exposure therapy.NeuroImage. Clinical · 2020Article
- Reduced activity and connectivity of left amygdala in patients with schizophrenia treated with clozapine or olanzapine.European archives of psychiatry and clinical neuroscience · 2019Article
- Dysfunction between dorsal caudate and salience network associated with impaired cognitive flexibility in obsessive-compulsive disorder: A resting-state fMRI study.NeuroImage. Clinical · 2019Article
- Multivariate resting-state functional connectivity predicts response to cognitive behavioral therapy in obsessive-compulsive disorder.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent studies have shown that response inhibition is impaired in patients with obsessive-compulsive disorder and their unaffected siblings, suggesting that these deficits may be considered a cognitive endophenotype of obsessive-compulsive disorder. Structural and functional neural correlates of altered response inhibition have been identified in patients and siblings. This study aims to examine the functional integrity of the response inhibition network in patients with obsessive-compulsive disorder and their unaffected siblings.
methodsForty-one unmedicated patients with obsessive-compulsive disorder, 17 of their unaffected siblings and 37 healthy controls performed a stop signal task during functional magnetic resonance imaging. Psycho-physiological interaction analysis was used to examine functional connectivity between the following regions of interest: the bilateral inferior frontal gyri, presupplementary motor area, subthalamic nuclei, inferior parietal lobes, anterior cingulate cortex, and amygdala. We then used dynamic causal modeling to investigate the directionality of the networks involved.
resultsPatients, and to a lesser extent also their unaffected siblings, show altered connectivity between the inferior frontal gyrus and the amygdala during response inhibition. The follow-up dynamic causal modeling suggests a bottom-up influence of the amygdala on the inferior frontal gyrus in healthy controls, whereas processing occurs top-down in patients with obsessive-compulsive, and in both directions in siblings.
conclusionsOur findings suggest that amygdala activation in obsessive-compulsive disorder interferes differently with the task-related recruitment of the inhibition network, underscoring the role of limbic disturbances in cognitive dysfunctions in obsessive-compulsive disorder.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.