ArticleJournal of applied physiology (Bethesda, Md. : 1985)2015
Exercise training causes differential changes in gene expression in diaphragm arteries and 2A arterioles of obese rats.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 14 citations in OpenAlex.
- Mechanoreceptor-mediated adaptations to physical exercise: from acute responses to long-term training effects.Cellular and molecular life sciences : CMLS · 2026Review
- Genetic silencing of KChannels (Austin, Tex.) · 2025Article
- Article
- Functional and structural adaptations of the coronary macro- and microvasculature to regular aerobic exercise by activation of physiological, cellular, and molecular mechanisms: ESC Working Group on Coronary Pathophysiology and Microcirculation position paper.Cardiovascular research · 2022Review
- Type 2 diabetes and cardiometabolic risk may be associated with increase in DNA methylation ofClinical epigenetics · 2018Article
- Vascular Adaptation to Exercise in Humans: Role of Hemodynamic Stimuli.Physiological reviews · 2017Review
- Transcriptomic effects of metformin in skeletal muscle arteries of obese insulin-resistant rats.Experimental biology and medicine (Maywood, N.J.) · 2017Article
- Transcriptomic differences in intra-abdominal adipose tissue in extremely obese adolescents with different stages of NAFLD.Physiological genomics · 2016Article
- Impact of external pneumatic compression target inflation pressure on transcriptome-wide RNA expression in skeletal muscle.Physiological reports · 2016Article
- Physical activity-induced remodeling of vasculature in skeletal muscle: role in treatment of type 2 diabetes.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Review
- Exercise-induced differential changes in gene expression among arterioles of skeletal muscles of obese rats.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
We employed next-generation, transcriptome-wide RNA sequencing (RNA-Seq) technology to assess the effects of two different exercise training protocols on transcriptional profiles in diaphragm second-order arterioles (D2a) and in the diaphragm feed artery (DFA) from Otsuka Long Evans Tokushima Fatty (OLETF) rats. Arterioles were isolated from the diaphragm of OLETF rats that underwent an endurance exercise training program (EX; n = 13), interval sprint training program (SPRINT; n = 14), or remained sedentary (Sed; n = 12). Our hypothesis was that exercise training would have similar effects on gene expression in the diaphragm and soleus muscle arterioles because diaphragm blood flow increases during exercise to a similar extent as in soleus. Results reveal that several canonical pathways that were significantly altered by exercise in limb skeletal muscles were not among the pathways significantly changed in the diaphragm arterioles including actin cytoskeleton signaling, role of NFAT in regulation of immune response, protein kinase A signaling, and protein ubiquitination pathway. EX training altered the expression of a smaller number of genes than did SPRINT in the DFA but induced a larger number of genes with altered expression in the D2a than did SPRINT. In fact, FDR differential expression analysis (FDR, 10%) indicated that only two genes exhibited altered expression in D2a of SPRINT rats. Very few of the genes that exhibited altered expression in the DFA or D2a were also altered in limb muscle arterioles. Finally, results indicate that the 2a arterioles of soleus muscle (S2a) from endurance-trained animals and the DFA of SPRINT animals exhibited the largest number of genes with altered expression.
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