Evidence map›Paper›PMID 26183468›Full record

ArticleBrain structure & function2016

Anxiety is related to indices of cortical maturation in typically developing children and adolescents.

Erik Newman, Wesley K Thompson, Hauke Bartsch, Donald J Hagler, Chi-Hua Chen, Timothy T Brown, Joshua M Kuperman, Connor McCabe, Yoonho Chung, Ondrej Libiger and 17 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain structure & function, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
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  7. Structural Brain Correlates of Anxiety During Development.Current topics in behavioral neurosciences · 2025
    Review
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  17. Subclinical Anxiety and Posttraumatic Stress Influence Cortical Thinning During Adolescence.Journal of the American Academy of Child and Adolescent Psychiatry · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Erik NewmanCenter for Human Development, University of California, San Diego, 9500 Gilman Drive, MC 0115, La Jolla, CA, 92093, USA. enewman@ucsd.edu.
Wesley K ThompsonDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
Hauke BartschMultimodal Imaging Laboratory, University of California, San Diego, La Jolla, CA, USA.
Donald J HaglerMultimodal Imaging Laboratory, University of California, San Diego, La Jolla, CA, USA.
Chi-Hua ChenDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
Timothy T BrownMultimodal Imaging Laboratory, University of California, San Diego, La Jolla, CA, USA.
Joshua M KupermanMultimodal Imaging Laboratory, University of California, San Diego, La Jolla, CA, USA.
Connor McCabeCenter for Human Development, University of California, San Diego, 9500 Gilman Drive, MC 0115, La Jolla, CA, 92093, USA.
Yoonho ChungCenter for Human Development, University of California, San Diego, 9500 Gilman Drive, MC 0115, La Jolla, CA, 92093, USA.
Ondrej LibigerScripps Genomic Medicine, Scripps Translational Science Institute and Scripps Health, La Jolla, CA, USA.
Natacha AkshoomoffCenter for Human Development, University of California, San Diego, 9500 Gilman Drive, MC 0115, La Jolla, CA, 92093, USA.
Cinnamon S BlossScripps Genomic Medicine, Scripps Translational Science Institute and Scripps Health, La Jolla, CA, USA.
B J CaseySackler Institute for Developmental Psychobiology, Weil Cornell Medical College, New York, NY, USA.
Linda ChangDepartment of Medicine, University of Hawaii and Queen's Medical Center, Honolulu, HI, USA.
Thomas M ErnstDepartment of Medicine, University of Hawaii and Queen's Medical Center, Honolulu, HI, USA.
Jean A FrazierDepartment of Psychiatry, University of Massachusetts Medical School, Boston, MA, USA.
Jeffrey R GruenDepartment of Pediatrics, Yale University School of Medicine, New Haven, CT, USA.
David N KennedyDepartment of Psychiatry, University of Massachusetts Medical School, Boston, MA, USA.
Sarah S MurrayDepartment of Pathology, University of California, San Diego, La Jolla, CA, USA.
Elizabeth R SowellDepartment of Pediatrics, University of Southern California, Los Angeles, CA, USA.
Nicholas SchorkScripps Genomic Medicine, Scripps Translational Science Institute and Scripps Health, La Jolla, CA, USA.
Tal KenetDepartment of Neurology and Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.
Walter E KaufmannBoston Children's Hospital and Harvard Medical School, Boston, MA, USA.
Stewart MostofskyKennedy Krieger Institute and Johns Hopkins University School of Medicine, Baltimore, MD, USA.
David G AmaralDepartment of Psychiatry and Behavioral Sciences, University of California, Davis, Davis, CA, USA.
Anders M DaleMultimodal Imaging Laboratory, University of California, San Diego, La Jolla, CA, USA.
Terry L JerniganCenter for Human Development, University of California, San Diego, 9500 Gilman Drive, MC 0115, La Jolla, CA, 92093, USA.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Creating a Pediatric Imaging-Genomics Data ResourceRC2DA029475 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHANG, LINDA, DALE, ANDERS M · 2009 to 2011
$9.1M
Translational Neuroscience CoreU54HD079123 · NICHD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI FATEMI, S. ALI, SCHLAGGAR, BRADLEY L · 2014 to 2019
$7.9M
Exposing the Deep Content of the Publication: Knowledge Extraction for Neuroimaging in Child PsychiatryR01MH083320 · NIMH · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI FRAZIER, JEAN A, KENNEDY, DAVID NELSON · 2009 to 2020
$6.3M
Mouse Neurodevelopmental Behavior CoreU54HD090255 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI SAHIN, MUSTAFA · 2016 to 2020
$5.2M
Mapping Individual Cognitive Differences to Neural Variance and School ReadinessR01HD061414 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JERNIGAN, TERRY L. · 2010 to 2014
$3.3M
Polygenicity, Pleiotrophy and Power: Novel Statistical Methods for Gene DiscoveryR01GM104400 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI THOMPSON, WESLEY KURT · 2014 to 2017
$1.6M
NCATS NIH HHS UL1 TR001863NICHD NIH HHS R01 HD061414NICHD NIH HHS U54 HD079123NICHD NIH HHS U54 HD090255NIDA NIH HHS RC2 DA029475NIGMS NIH HHS R01 GM104400NIMH NIH HHS R01 MH083320
6 · The paper itself

Abstract

Anxiety is a risk factor for many adverse neuropsychiatric and socioeconomic outcomes, and has been linked to functional and structural changes in the ventromedial prefrontal cortex (VMPFC). However, the nature of these differences, as well as how they develop in children and adolescents, remains poorly understood. More effective interventions to minimize the negative consequences of anxiety require better understanding of its neurobiology in children. Recent research suggests that structural imaging studies may benefit from clearly delineating between cortical surface area and thickness when examining these associations, as these distinct cortical phenotypes are influenced by different cellular mechanisms and genetic factors. The present study examined relationships between cortical surface area and thickness of the VMPFC and a self-report measure of anxiety (SCARED-R) in 287 youths aged 7-20 years from the Pediatric Imaging, Neurocognition, and Genetics (PING) study. Age and gender interactions were examined for significant associations in order to test for developmental differences. Cortical surface area and thickness were also examined simultaneously to determine whether they contribute independently to the prediction of anxiety. Anxiety was negatively associated with relative cortical surface area of the VMPFC as well as with global cortical thickness, but these associations diminished with age. The two cortical phenotypes contributed additively to the prediction of anxiety. These findings suggest that higher anxiety in children may be characterized by both delayed expansion of the VMPFC and an altered trajectory of global cortical thinning. Further longitudinal studies will be needed to confirm these findings.

Indexed as

AdolescentAdultAge FactorsAnxietyAnxiety DisordersChildDiffusion Magnetic Resonance ImagingFemaleHumansMalePrefrontal CortexPsychiatric Status Rating ScalesRisk FactorsSelf ReportSex FactorsYoung AdultAnxietyBrain developmentCortical surface areaCortical thicknessMagnetic resonance imagingVentromedial prefrontal cortex

Identifiers

PMID26183468
PMCPMC5064818

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.