Evidence map›Paper›PMID 26183338›Full record

ArticleResearch in developmental disabilities

Capturing neuroplastic changes after bimanual intensive rehabilitation in children with unilateral spastic cerebral palsy: A combined DTI, TMS and fMRI pilot study.

Yannick Bleyenheuft, Laurence Dricot, Nathalie Gilis, Hsing-Ching Kuo, Cécile Grandin, Corinne Bleyenheuft, Andrew M Gordon, Kathleen M Friel

2 registry-linked trialsOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Research in developmental disabilities. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 40 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 3 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05740605 narecruitingnot on this map

Implementation of a HABIT-ILE at Home Intervention for Children With Bilateral Cerebral Palsy: a Non-inferiority Randomized Controlled Trial

TypeinterventionalSponsorUniversité Catholique de LouvainRan2023 to 2027Enrolled48ConditionsCerebral PalsyArmsHand-Arm Bimanual Intensive Therapy Including Lower Extremities (HABIT-ILE), Hand-Arm Bimanual Intensive Therapy Including Lower Extremities at home, Follow-up Hand-Arm Bimanual Intensive Therapy Including Lower Extremities, Usual Care
NCT07506837 nanot yet recruitingnot on this map

Effects of Intensive Motor Control-Based Therapy for Upper and Lower Extremities in Children With Cerebral Palsy

TypeinterventionalSponsorUniversidad Europea de MadridRan2027 to 2028Enrolled30ConditionsCerebral PalsyArmsHABIT-ILE
3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 3 syntheses or guidelines pooled it, 80 citations in OpenAlex.

  1. Pooled it
  2. Neural Correlates of Mobility in Children with Cerebral Palsy: A Systematic Review.International journal of environmental research and public health · 2024
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  16. Corpus Callosum Functional Activities in Children with Cerebral Palsy.Journal of biomedical physics & engineering · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Yannick BleyenheuftInstitute of Neuroscience, Université catholique de Louvain, Brussels, Belgium. Electronic address: Yannick.bleyenheuft@uclouvain.be.
Laurence DricotInstitute of Neuroscience, Université catholique de Louvain, Brussels, Belgium.
Nathalie GilisInstitute of Neuroscience, Université catholique de Louvain, Brussels, Belgium.
Hsing-Ching KuoDepartment of Biobehavioral Sciences, Teachers College, Columbia University, New York, USA.
Cécile GrandinInstitute of Neuroscience, Université catholique de Louvain, Brussels, Belgium; Radioloy Service, Clinques Universitaires Saint-Luc, Brussels, Belgium.
Corinne BleyenheuftInstitute of Neuroscience, Université catholique de Louvain, Brussels, Belgium; Physical Medicine and Rehabilitation Service, CHU Mont-Godinne, Yvoir, Belgium.
Andrew M GordonDepartment of Biobehavioral Sciences, Teachers College, Columbia University, New York, USA.
Kathleen M FrielDepartment of Biobehavioral Sciences, Teachers College, Columbia University, New York, USA; Burke-Cornell Medical Research Institute, White Plains, NY, USA.
UCLouvain · BEColumbia University · USCHU Dinant Godinne UCL Namur · BECliniques Universitaires Saint-Luc · BECornell University · US

Funding

Targeted transcranial direct current stimulation combined with bimanual training for children with cerebral palsyR01HD076436 · NICHD · WINIFRED MASTERSON BURKE MED RES INST · PI GORDON, ANDREW M., RATNADURAI GIRIDHARAN, SHIVAKESHAVAN · 2014 to 2024
$5.5M
Mechanisms of cerebral palsy recovery induced by balancing motor cortex activityK01NS062116 · NINDS · WINIFRED MASTERSON BURKE MED RES INST · PI FRIEL, KATHLEEN MARGARET · 2008 to 2012
$853k
NICHD NIH HHS R01 HD076436NINDS NIH HHS K01 NS062116NINDS NIH HHS NS K01062116
6 · The paper itself

Abstract

Intensive rehabilitation interventions have been shown to be efficacious in improving upper extremity function in children with unilateral spastic cerebral palsy (USCP). These interventions are based on motor learning principles and engage children in skillful movements. Improvements in upper extremity function are believed to be associated with neuroplastic changes. However, these neuroplastic changes have not been well-described in children with cerebral palsy, likely due to challenges in defining and implementing the optimal tools and tests in children. Here we documented the implementation of three different neurological assessments (diffusion tensor imaging-DTI, transcranial magnetic stimulation-TMS and functional magnetic resonance imaging-fMRI) before and after a bimanual intensive treatment (HABIT-ILE) in two children with USCP presenting differential corticospinal developmental reorganization (ipsilateral and contralateral). The aim of the study was to capture neurophysiological changes and to document the complementary relationship between these measures, the potential measurable changes and the feasibility of applying these techniques in children with USCP. Independent of cortical reorganization, both children showed increases in activation and size of the motor areas controlling the affected hand, quantified with different techniques. In addition, fMRI provided additional unexpected changes in the reward circuit while using the affected hand.

Indexed as

Physical Therapy ModalitiesBrainBrain MappingCerebral PalsyChildDiffusion Tensor ImagingFemaleFunctional NeuroimagingHumansMagnetic Resonance ImagingMotor CortexPilot ProjectsStrokeTranscranial Magnetic StimulationTreatment OutcomeBimanual trainingCerebral palsyDTIfMRITMS

Identifiers

PMID26183338
PMCPMC4871716
OpenAlexW1683505690

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.