Evidence map›Paper›PMID 26183251›Full record

ArticleBone2015

Bone's responses to mechanical loading are impaired in type 1 diabetes.

Ashutosh Parajuli, Chao Liu, Wen Li, Xiaoyu Gu, Xiaohan Lai, Shaopeng Pei, Christopher Price, Lidan You, X Lucas Lu, Liyun Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 2 pooled it
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.

  1. Trabecular bone score in adults with type 1 diabetes: a meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024
    Pooled it
  2. Methodological aspects ofJournal of musculoskeletal & neuronal interactions · 2023
    Pooled it
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  11. Biochemical Markers of Bone Turnover in Older Adults With Type 1 Diabetes.The Journal of clinical endocrinology and metabolism · 2022
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  17. Hip Structural Analysis Reveals Impaired Hip Geometry in Girls With Type 1 Diabetes.The Journal of clinical endocrinology and metabolism · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Ashutosh ParajuliDepartment of Biomedical Engineering, University of Delaware, Newark, DE 19716, USA. Electronic address: parajuli.ashutosh@gmail.com.
Chao LiuDepartment of Mechanical and Industrial Engineering, Institute of Biomaterials and Biomedical Engineering, University of Toronto, Ontario, Canada.
Wen LiDepartment of Mechanical Engineering, University of Delaware, Newark, DE 19716, USA. Electronic address: wenli@udel.edu.
Xiaoyu GuDepartment of Mechanical Engineering, University of Delaware, Newark, DE 19716, USA. Electronic address: davegu@udel.edu.
Xiaohan LaiDepartment of Mechanical Engineering, University of Delaware, Newark, DE 19716, USA. Electronic address: laixhan@udel.edu.
Shaopeng PeiDepartment of Mechanical Engineering, University of Delaware, Newark, DE 19716, USA. Electronic address: shaopeng@udel.edu.
Christopher PriceDepartment of Biomedical Engineering, University of Delaware, Newark, DE 19716, USA. Electronic address: cprice@udel.edu.
Lidan YouDepartment of Mechanical and Industrial Engineering, Institute of Biomaterials and Biomedical Engineering, University of Toronto, Ontario, Canada. Electronic address: youlidan@mie.utoronto.ca.
X Lucas LuDepartment of Biomedical Engineering, University of Delaware, Newark, DE 19716, USA; Department of Mechanical Engineering, University of Delaware, Newark, DE 19716, USA. Electronic address: xlu@udel.edu.
Liyun WangDepartment of Biomedical Engineering, University of Delaware, Newark, DE 19716, USA; Department of Mechanical Engineering, University of Delaware, Newark, DE 19716, USA. Electronic address: lywang@udel.edu.
University of Delaware · USUniversity of Toronto · CA

Funding

Pilot Project ProgramP30GM103333 · NIGMS · UNIVERSITY OF DELAWARE · PI BUCHANAN, THOMAS S · 2012 to 2016
$5.7M
Supplement to R01 Titled: Mechanosensing in the Bone Lacunar-Canalicular SystemR01AR054385 · NIAMS · UNIVERSITY OF DELAWARE · PI FARACH-CARSON, MARY C, WANG, LIYUN · 2007 to 2019
$3.8M
NIAMS NIH HHS AR054385NIAMS NIH HHS R01 AR054385NIGMS NIH HHS P30 GM103333NIGMS NIH HHS P30GM103333
6 · The paper itself

Abstract

Diabetes adversely impacts many organ systems including the skeleton. Clinical trials have revealed a startling elevation in fracture risk in diabetic patients. Bone fractures can be life threatening: nearly 1 in 6 hip fracture patients die within one year. Because physical exercise is proven to improve bone properties and reduce fracture risk in non-diabetic subjects, we tested its efficacy in type 1 diabetes. We hypothesized that diabetic bone's response to anabolic mechanical loading would be attenuated, partially due to impaired mechanosensing of osteocytes under hyperglycemia. Heterozygous C57BL/6-Ins2(Akita)/J (Akita) male and female diabetic mice and their age- and gender-matched wild-type (WT) C57BL/6J controls (7-month-old, N=5-7 mice/group) were subjected to unilateral axial ulnar loading with a peak strain of 3500 με at 2 Hz and 3 min/day for 5 days. The Akita female mice, which exhibited a relatively normal body weight and a mild 40% elevation of blood glucose level, responded with increased bone formation (+6.5% in Ct.B.Ar, and 4 to 36-fold increase in Ec.BFR/BS and Ps.BFR/BS), and the loading effects, in terms of changes of static and dynamic indices, did not differ between Akita and WT females (p ≥ 0.1). However, loading-induced anabolic effects were greatly diminished in Akita males, which exhibited reduced body weight, severe hyperglycemia (+230%), diminished bone formation (ΔCt.B.Ar: 0.003 vs. 0.030 mm(2), p=0.005), and suppressed periosteal bone appositions (ΔPs.BFR/BS, p=0.02). Hyperglycemia (25 mM glucose) was further found to impair the flow-induced intracellular calcium signaling in MLO-Y4 osteocytes, and significantly inhibited the flow-induced downstream responses including reduction in apoptosis and sRANKL secretion and PGE2 release. These results, along with previous findings showing adverse effects of hyperglycemia on osteoblasts and mesenchymal stem cells, suggest that failure to maintain normal glucose levels may impair bone's responses to mechanical loading in diabetics.

Indexed as

AnimalsCells, CulturedDiabetes Mellitus, Type 1FemaleMaleMiceMice, Inbred C57BLOsteogenesisRatsUlnaWeight-BearingAkita diabetic mouseBone formationFluid flowOsteocyte mechanosensitivityUlnar mechanical loading

Identifiers

PMID26183251
PMCPMC4640966
OpenAlexW1652067119

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.