ArticleTAG. Theoretical and applied genetics. Theoretische und angewandte Genetik2015
Functional divergence of duplicated genes results in a novel blast resistance gene Pi50 at the Pi2/9 locus.
Article in TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- A multi-race blast resistance locus identified and validated in US elite rice via association and biparental mapping.The plant genome · 2026Article
- Genome-wide prediction of cloned disease resistance homologues across the Oryza genus.The plant genome · 2026Article
- Evaluating Blast Resistance of Huang-Huai Geng/Japonica Varieties Using Intragenic Markers.Rice (New York, N.Y.) · 2026Article
- Research Progress on Rice-Blast-Resistance-Related Genes.Plants (Basel, Switzerland) · 2025Review
- Enhancing the blast resistance of an elite thermo-sensitive genic male sterile line (TGMS) Longke638S and its derived hybrid varieties by incorporatingMolecular breeding : new strategies in plant improvement · 2025Article
- Status on Genetic Resistance to Rice Blast Disease in the Post-Genomic Era.Plants (Basel, Switzerland) · 2025Review
- Molecular breeding approaches for sustainable rice blast management: recent advances and challenges.Frontiers in plant science · 2025Review
- Identification of significant SNPs and candidate loci for blast disease resistance via GWAS and population structure analysis in ARC panel ofPhysiology and molecular biology of plants : an international journal of functional plant biology · 2024Article
- Current status of molecular rice breeding for durable and broad-spectrum resistance to major diseases and insect pests.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Review
- Allelic variation in rice blast resistance: a pathway to sustainable disease management.Molecular biology reports · 2024Review
- Superior haplotypes towards the development of blast and bacterial blight-resistant rice.Frontiers in plant science · 2024Article
- Recent Advances in Effector Research ofBiomolecules · 2023Review
- Available cloned genes and markers for genetic improvement of biotic stress resistance in rice.Frontiers in plant science · 2023Review
- Advancement in the Breeding, Biotechnological and Genomic Tools towards Development of Durable Genetic Resistance against the Rice Blast Disease.Plants (Basel, Switzerland) · 2022Review
- Understanding the Dynamics of Blast Resistance in Rice-Journal of fungi (Basel, Switzerland) · 2022Review
- Recent Progress in Rice Broad-Spectrum Disease Resistance.International journal of molecular sciences · 2021Review
- Rice miR1432 Fine-Tunes the Balance of Yield and Blast Disease Resistance via Different Modules.Rice (New York, N.Y.) · 2021Article
- Genome wide association studies for japonica rice resistance to blast in field and controlled conditions.Rice (New York, N.Y.) · 2020Article
- Identification of Blast Resistance QTLs Based on Two Advanced Backcross Populations in Rice.Rice (New York, N.Y.) · 2020Article
- Blast resistance gene Pi54 over-expressed in rice to understand its cellular and sub-cellular localization and response to different pathogens.Scientific reports · 2020Article
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10 authors.
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Abstract
key messageWe characterized a novel blast resistance gene Pi50 at the Pi2/9 locus; Pi50 is derived from functional divergence of duplicated genes. The unique features of Pi50 should facilitate its use in rice breeding and improve our understanding of the evolution of resistance specificities. Rice blast disease, caused by the fungal pathogen Magnaporthe oryzae, poses constant, major threats to stable rice production worldwide. The deployment of broad-spectrum resistance (R) genes provides the most effective and economical means for disease control. In this study, we characterize the broad-spectrum R gene Pi50 at the Pi2/9 locus, which is embedded within a tandem cluster of 12 genes encoding proteins with nucleotide-binding site and leucine-rich repeat (NBS-LRR) domains. In contrast with other Pi2/9 locus, the Pi50 cluster contains four duplicated genes (Pi50_NBS4_1 to 4) with extremely high nucleotide sequence similarity. Moreover, these duplicated genes encode two kinds of proteins (Pi50_NBS4_1/2 and Pi50_NBS4_3/4) that differ by four amino acids. Complementation tests and resistance spectrum analyses revealed that Pi50_NBS4_1/2, not Pi50_NBS4_3/4, control the novel resistance specificity as observed in the Pi50 near isogenic line, NIL-e1. Pi50 shares greater than 96 % amino acid sequence identity with each of three other R proteins, i.e., Pi9, Piz-t, and Pi2, and has amino acid changes predominantly within the LRR region. The identification of Pi50 with its novel resistance specificity will facilitate the dissection of mechanisms behind the divergence and evolution of different resistance specificities at the Pi2/9 locus.
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