ArticleEuropean archives of psychiatry and clinical neuroscience2016
The role of hypothalamus-pituitary-adrenal genes and childhood trauma in borderline personality disorder.
Article in European archives of psychiatry and clinical neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 59 citations in OpenAlex.
- Differential methylation of OPRK1 in borderline personality disorder is associated with childhood trauma.Molecular psychiatry · 2024Article
- Relationship Dysfunction in Couples When One Partner Is Diagnosed with Borderline Personality Disorder: Findings from a Pilot Study.Behavioral sciences (Basel, Switzerland) · 2023Article
- Role of FKBP5 and its genetic mutations in stress-induced psychiatric disorders: an opportunity for drug discovery.Frontiers in psychiatry · 2023Review
- Association Between Adverse Childhood Experiences, Resilience and Mental Health in a Hispanic Community.Journal of child & adolescent trauma · 2022Article
- Experiences of Compassion in Adults With a Diagnosis of Borderline Personality Disorder: An Interpretative Phenomenological Analysis.Psychological reports · 2022Article
- Borderline Personality Disorder: Risk Factors and Early Detection.Diagnostics (Basel, Switzerland) · 2021Review
- A genome-wide methylation study reveals X chromosome and childhood trauma methylation alterations associated with borderline personality disorder.Translational psychiatry · 2021Article
- The Role of Trauma in Early Onset Borderline Personality Disorder: A Biopsychosocial Perspective.Frontiers in psychiatry · 2021Review
- Insomnia in Patients with Borderline Personality Disorder.Nature and science of sleep · 2021Review
- Borderline personality disorder, trauma, and the hypothalamus-pituitary-adrenal axis.Neuropsychiatric disease and treatment · 2019Article
- Current Knowledge on Gene-Environment Interactions in Personality Disorders: an Update.Current psychiatry reports · 2018Review
- The emerging role of the FKBP5 gene polymorphisms in vulnerability-stress model of schizophrenia: further evidence from a Serbian population.European archives of psychiatry and clinical neuroscience · 2017Article
- miR-34b attenuates trauma-induced anxiety-like behavior by targeting CRHR1.International journal of molecular medicine · 2017Article
- Borderline personality disorder and childhood trauma: exploring the affected biological systems and mechanisms.BMC psychiatry · 2017Review
- Psychiatric Symptoms in Patients with Cushing's Syndrome: Prevalence, Diagnosis and Management.Drugs · 2017Review
- Early adverse experience and substance addiction: dopamine, oxytocin, and glucocorticoid pathways.Annals of the New York Academy of Sciences · 2017Review
- Understanding gene × early adversity interactions: possibilities for insight in the biology of psychiatric disorders.European archives of psychiatry and clinical neuroscience · 2017Article
- Neurobiological background of borderline personality disorder, PTSD and ADHD.European archives of psychiatry and clinical neuroscience · 2016Article
- Genetic and Neuroimaging Features of Personality Disorders: State of the Art.Neuroscience bulletin · 2016Review
- The age-dependent plasticity highlights the conceptual interface between borderline personality disorder and PTSD.European archives of psychiatry and clinical neuroscience · 2016Article
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Authors and funding
15 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Current knowledge suggests that borderline personality disorder (BPD) results from the interaction between genetic and environmental factors. Research has mainly focused on monoaminergic genetic variants and their modulation by traumatic events, especially those occurring during childhood. However, to the best of our knowledge, there are no studies on the genetics of hypothalamus-pituitary-adrenal (HPA) axis, despite its vulnerability to early stress and its involvement in BPD pathogenesis. The aim of this study was to investigate the contribution of genetic variants in the HPA axis and to explore the modulating effect of childhood trauma in a large sample of BPD patients and controls. DNA was obtained from a sample of 481 subjects with BPD and 442 controls. Case-control differences in allelic frequencies of 47 polymorphisms in 10 HPA axis genes were analysed. Modulation of genetic associations by the presence of childhood trauma was also investigated by dividing the sample into three groups: BPD with trauma, BPD without trauma and controls. Two FKBP5 polymorphisms (rs4713902-C and rs9470079-A) showed significant associations with BPD. There were also associations between BPD and haplotype combinations of the genes FKBP5 and CRHR1. Two FKBP5 alleles (rs3798347-T and rs10947563-A) were more frequent in BPD subjects with history of physical abuse and emotional neglect and two CRHR2 variants (rs4722999-C and rs12701020-C) in BPD subjects with sexual and physical abuse. Our findings suggest a contribution of HPA axis genetic variants to BPD pathogenesis and reinforce the hypothesis of the modulating effect of childhood trauma in the development of this disorder.
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