ArticlePLoS pathogens2015
Vaccination Drives Changes in Metabolic and Virulence Profiles of Streptococcus pneumoniae.
Article in PLoS pathogens, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Epistasis mediates the role of negative frequency-dependent selection in bacterial strain structure.PLoS computational biology · 2026Article
- Convergent impact of vaccination and antibiotic pressures on pneumococcal populations.Cell chemical biology · 2024Review
- Darwin review: the evolution of virulence in human pathogens.Proceedings. Biological sciences · 2024Review
- Pneumococcal population genomics changes during the early time period of conjugate vaccine uptake in southern India.Microbial genomics · 2024Article
- Vaccine-induced strain replacement: theory and real-life implications.Future microbiology · 2024Review
- Pneumococcal population dynamics: Investigating vaccine-induced changes through multiscale modelling.PLoS computational biology · 2023Article
- The metabolic, virulence and antimicrobial resistance profiles of colonising Streptococcus pneumoniae shift after PCV13 introduction in urban Malawi.Nature communications · 2023Article
- Evolution of pathogen virulence: Studying the complex interplay of pathogen interactions, virulence and transmission helps us understand how they evolve and spread.EMBO reports · 2023Article
- Non-pharmaceutical interventions and the emergence of pathogen variants.Evolution, medicine, and public health · 2023Article
- Negative frequency-dependent selection and asymmetrical transformation stabilise multi-strain bacterial population structures.The ISME journal · 2021Article
- Pneumococcal Competition Modulates Antibiotic Resistance in the Pre-Vaccination Era: A Modelling Study.Vaccines · 2021Article
- Intra-Species Interactions inFrontiers in cellular and infection microbiology · 2021Article
- Frequency-dependent selection can forecast evolution in Streptococcus pneumoniae.PLoS biology · 2020Article
- High residual carriage of vaccine-serotype Streptococcus pneumoniae after introduction of pneumococcal conjugate vaccine in Malawi.Nature communications · 2020Observational
- Correlates of Nonrandom Patterns of Serotype Switching in Pneumococcus.The Journal of infectious diseases · 2020Article
- Determinants of high residual post-PCV13 pneumococcal vaccine-type carriage in Blantyre, Malawi: a modelling study.BMC medicine · 2019Article
- Diversity-Generating Machines: Genetics of Bacterial Sugar-Coating.Trends in microbiology · 2018Review
- Global emergence and population dynamics of divergent serotype 3 CC180 pneumococci.PLoS pathogens · 2018Article
- The amino acid selected for generating mutant TbpB antigens defective in binding transferrin can compromise the in vivo protective capacity.Scientific reports · 2018Article
- The impact of serotype-specific vaccination on phylodynamic parameters of Streptococcus pneumoniae and the pneumococcal pan-genome.PLoS pathogens · 2018Observational
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The bacterial pathogen, Streptococcus pneumoniae (the pneumococcus), is a leading cause of life-threatening illness and death worldwide. Available conjugate vaccines target only a small subset (up to 13) of >90 known capsular serotypes of S. pneumoniae and, since their introduction, increases in non-vaccine serotypes have been recorded in several countries: a phenomenon termed Vaccine Induced Serotype Replacement (VISR). Here, using a combination of mathematical modelling and whole genome analysis, we show that targeting particular serotypes through vaccination can also cause their metabolic and virulence-associated components to transfer through recombination to non-vaccine serotypes: a phenomenon we term Vaccine-Induced Metabolic Shift (VIMS). Our results provide a novel explanation for changes observed in the population structure of the pneumococcus following vaccination, and have important implications for strain-targeted vaccination in a range of infectious disease systems.
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Registered trials
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