Evidence map›Paper›PMID 26181705›Full record

Trial reportJournal of acquired immune deficiency syndromes (1999)2015

An Algorithm Approach to Determining Smoking Cessation Treatment for Persons Living With HIV/AIDS: Results of a Pilot Trial.

Karen L Cropsey, Bianca F Jardin, Greer A Burkholder, C Brendan Clark, James L Raper, Michael S Saag

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of acquired immune deficiency syndromes (1999), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Interventions for tobacco use cessation in people living with HIV.The Cochrane database of systematic reviews · 2024
    Pooled it
  2. Antidepressants for smoking cessation.The Cochrane database of systematic reviews · 2020
    Pooled it
  3. A Qualitative Systematic Review of Cigarette Smoking Cessation Interventions for Persons Living with HIV.Journal of cancer education : the official journal of the American Association for Cancer Education · 2019
    Pooled it
  4. Trial
  5. Trial
  6. Trial
  7. Article
  8. Article
  9. Antidepressants for smoking cessation.The Cochrane database of systematic reviews · 2023
    Review
  10. COPD in People with HIV: Epidemiology, Pathogenesis, Management, and Prevention Strategies.International journal of chronic obstructive pulmonary disease · 2023
    Review
  11. Article
  12. Article
  13. Evaluation of a Proactive Smoking Cessation Electronic Visit to Extend the Reach of Evidence-Based Cessation Treatment via Primary Care.Telemedicine journal and e-health : the official journal of the American Telemedicine Association · 2021
    Article
  14. Article
  15. Article
  16. Article
  17. Lung cancer in persons with HIV.Current opinion in HIV and AIDS · 2017
    Review
  18. Smoking Cessation for People Living With HIV/AIDS: A Literature Review and Synthesis.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2016
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Karen L Cropsey*Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL; †Division of Psychiatry, Roper St. Francis Hospital, Charleston, SC; and ‡Department of Internal Medicine, Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL.
Bianca F Jardin
Greer A Burkholder
C Brendan Clark
James L Raper
Michael S Saag

Funding

Virology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Paul A. Goepfert · 1988 to 2026
$84.1M
Training: Molecular & Cellular Bases of Infectious DiseasesT32AI007417 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Arturo Casadevall · 1994 to 2026
$11.9M
Integrated Smoking Cessation Treatment for Low Income Community CorrectionsR01CA141663 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CROPSEY, KAREN L · 2009 to 2013
$1.3M
NCI NIH HHS R01 CA141663NIAID NIH HHS P30 AI027767NIAID NIH HHS T32AI007417
6 · The paper itself

Abstract

backgroundSmoking now represents one of the biggest modifiable risk factors for disease and mortality in people living with HIV (PLHIV). To produce significant changes in smoking rates among this population, treatments will need to be both acceptable to the larger segment of PLHIV smokers and feasible to implement in busy HIV clinics. The purpose of this study was to evaluate the feasibility and effects of a novel proactive algorithm-based intervention in an HIV/AIDS clinic.

methodsPLHIV smokers (N = 100) were proactively identified through their electronic medical records and were subsequently randomized at baseline to receive a 12-week pharmacotherapy-based algorithm treatment or treatment as usual. Participants were tracked in-person for 12 weeks. Participants provided information on smoking behaviors and associated constructs of cessation at each follow-up session.

resultsThe findings revealed that many smokers reported using prescribed medications when provided with a supply of cessation medication as determined by an algorithm. Compared with smokers receiving treatment as usual, PLHIV smokers prescribed these medications reported more quit attempts and greater reduction in smoking. Proxy measures of cessation readiness (eg, motivation, self-efficacy) also favored participants receiving algorithm treatment.

conclusionsThis algorithm-derived treatment produced positive changes across a number of important clinical markers associated with smoking cessation. Given these promising findings coupled with the brief nature of this treatment, the overall pattern of results suggests strong potential for dissemination into clinical settings and significant promise for further advancing clinical health outcomes in this population.

Indexed as

AlgorithmsAdultBenzazepinesBupropionDopamine Uptake InhibitorsFemaleHIV InfectionsHumansMaleMiddle AgedNicotinic AgonistsPilot ProjectsQuinoxalinesSmokingSmoking CessationTobacco Use Cessation DevicesBenzazepinesBupropionDopamine Uptake InhibitorsNicotinic AgonistsQuinoxalinesVarenicline

Identifiers

PMID26181705
PMCPMC4505746

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.