ArticlePLoS pathogens2015
Existing Infection Facilitates Establishment and Density of Malaria Parasites in Their Mosquito Vector.
Article in PLoS pathogens, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Must Epidemiologically Impactful Vector Control Interventions Disrupt Mosquito Population Structure? A Case Study of a Cluster-Randomised Controlled Trial.Evolutionary applications · 2025Article
- Article
- Tick-to-host transmission differs betweenMicrobiology spectrum · 2023Article
- Targeting malaria parasites inside mosquitoes: ecoevolutionary consequences.Trends in parasitology · 2022Review
- Evolutionary consequences of vector-borne transmission: how using vectors shapes host, vector and pathogen evolution.Parasitology · 2022Review
- Article
- Parasite co-infection: an ecological, molecular and experimental perspective.Proceedings. Biological sciences · 2022Article
- Chromatin changes in Anopheles gambiae induced by Plasmodium falciparum infection.Epigenetics & chromatin · 2019Article
- Competition Between Strains ofFrontiers in cellular and infection microbiology · 2019Article
- Competition between strains ofProceedings. Biological sciences · 2018Article
- Transmission traits of malaria parasites within the mosquito: Genetic variation, phenotypic plasticity, and consequences for control.Evolutionary applications · 2018Article
- Rethinking the extrinsic incubation period of malaria parasites.Parasites & vectors · 2018Review
- Null expectations for disease dynamics in shrinking habitat: dilution or amplification?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Article
- Multistrain Infections with Lyme Borreliosis Pathogens in the Tick Vector.Applied and environmental microbiology · 2017Article
- Dynamics of gamete production and mating in the parasitic protist Trypanosoma brucei.Parasites & vectors · 2016Article
- Existing Infection Facilitates Establishment and Density of Malaria Parasites in Their Mosquito Vector.PLoS pathogens · 2015Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Very little is known about how vector-borne pathogens interact within their vector and how this impacts transmission. Here we show that mosquitoes can accumulate mixed strain malaria infections after feeding on multiple hosts. We found that parasites have a greater chance of establishing and reach higher densities if another strain is already present in a mosquito. Mixed infections contained more parasites but these larger populations did not have a detectable impact on vector survival. Together these results suggest that mosquitoes taking multiple infective bites may disproportionally contribute to malaria transmission. This will increase rates of mixed infections in vertebrate hosts, with implications for the evolution of parasite virulence and the spread of drug-resistant strains. Moreover, control measures that reduce parasite prevalence in vertebrate hosts will reduce the likelihood of mosquitoes taking multiple infective feeds, and thus disproportionally reduce transmission. More generally, our study shows that the types of strain interactions detected in vertebrate hosts cannot necessarily be extrapolated to vectors.
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Registered trials
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