Evidence map›Paper›PMID 26181330›Full record

ArticlePloS one2015

Trends in Incidence Rates during 1999-2008 and Prevalence in 2008 of Childhood Type 1 Diabetes Mellitus in Germany--Model-Based National Estimates.

Alexander Bendas, Ulrike Rothe, Wieland Kiess, Thomas Michael Kapellen, Thoralf Stange, Ulf Manuwald, Eckhard Salzsieder, Reinhard Walter Holl, Olaf Schoffer, Anna Stahl-Pehe and 4 more

Abstract read
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

  1. Well, How Did We Get Here? The Current State of Pediatric Endocrinology.Journal of pediatrics. Clinical practice · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Alexander BendasDepartment of Otorhinolaryngology, University Hospital Dresden, Dresden, Germany.
Ulrike RotheHealth Sciences/Public Health, Faculty of Medicine "Carl Gustav Carus", TU Dresden, Dresden, Germany.
Wieland KiessHospital for Children and Adolescents, Center for Pediatric Research, Department of Women and Child Health, University of Leipzig, Leipzig, Germany.
Thomas Michael KapellenHospital for Children and Adolescents, Center for Pediatric Research, Department of Women and Child Health, University of Leipzig, Leipzig, Germany.
Thoralf StangeInstitute for Medical Informatics and Biometry, Faculty of Medicine "Carl Gustav Carus", TU Dresden, Dresden, Germany.
Ulf ManuwaldHealth Sciences/Public Health, Faculty of Medicine "Carl Gustav Carus", TU Dresden, Dresden, Germany.
Eckhard SalzsiederInstitute of Diabetes "Gerhardt Katsch" Karlsburg, Karlsburg, Germany.
Reinhard Walter HollInstitute for Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany.
Olaf SchofferDepartment of Tumorepidemiology, Faculty of Medicine "Carl Gustav Carus", TU Dresden, Dresden, Germany.
Anna Stahl-PeheInstitute for Biometrics and Epidemiology, German Diabetes Centre, Leibniz Institute for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Guido GianiInstitute for Biometrics and Epidemiology, German Diabetes Centre, Leibniz Institute for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Stefan EhehaltPublic Health Department of Stuttgart, Department of Pediatrics, Dental Health Care, Health Promotion and Social Services, Stuttgart, Germany.
Andreas NeuUniversity Children's Hospital Tübingen, Tübingen, Germany.
Joachim RosenbauerInstitute for Biometrics and Epidemiology, German Diabetes Centre, Leibniz Institute for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsTo estimate the national incidence rate and trend of type 1 diabetes (T1DM) in Germany from 1999 to 2008 and the national prevalence in 2008 in the age group 0-14 years.

methodsData were taken from a nationwide registry for incident cases of T1DM in the ages 0-4 years and 3 regional registries (North-Rhine-Westphalia, Baden-Wuerttemberg and Saxony) for incident cases of T1DM in the ages 0-14 years covering 41% of the child population in Germany. The degree of ascertainment was ≥ 97% in all registries. Incident and prevalent cases were grouped by region, sex, age (0-4, 5-9, 10-14 years), and, for incident data, additionally by two 5-year periods (1999-2003, 2004-2008). Poisson regression models were fitted to the data to derive national estimates of incidence rate trends and prevalence in the age groups 5-9, 10-14 and 0-14 years. We used direct age-standardization.

resultsThe estimated national incidence rate in 0-14-year-olds increased significantly by 18.1% (95%CI: 11.6-25.0%, p<0.001) from 1999-2003 to 2004-2008, independent of sex, corresponding to an average annual increase of 3.4% (95%-CI: 2.2-4.6%). The overall incidence rate was estimated at 22.9 per 100,000 person-years and we identified a within-country west-east-gradient previously unknown. The national prevalence in the ages 0-14 years on 31/12/2008 was estimated to be 148.1 per 100,000 persons.

conclusionsThe national incidence rate of childhood T1DM in Germany is higher than in many other countries around the world. Importantly, the estimated trend of the incidence rate confirms the international data of a global increase of T1DM incidences.

Indexed as

RegistriesAdolescentAge DistributionChildChild, PreschoolDiabetes Mellitus, Type 1FemaleGermanyHumansIncidenceInfantInfant, NewbornMalePrevalenceSex Distribution

Identifiers

PMID26181330
PMCPMC4504467

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.