Evidence map›Paper›PMID 26181219›Full record

SynthesisCritical care medicine2015

Lung-Protective Ventilation With Low Tidal Volumes and the Occurrence of Pulmonary Complications in Patients Without Acute Respiratory Distress Syndrome: A Systematic Review and Individual Patient Data Analysis.

Ary Serpa Neto, Fabienne D Simonis, Carmen S V Barbas, Michelle Biehl, Rogier M Determann, Jonathan Elmer, Gilberto Friedman, Ognjen Gajic, Joshua N Goldstein, Rita Linko and 8 more

3 registry-linked trialsAbstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Critical care medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 112 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
112citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03698799 completednot on this mapstarted 2018, after this paper: background citation

Adherence Rate to Lung Protective Mechanical Ventilation in Patients Admitted to Surgical Intensive Care Units and Associated Clinical Outcomes

TypeobservationalSponsorMahidol UniversityRan2018 to 2020Enrolled306ConditionsAdult, Guideline Adherence, Humans, Intensive Care Units
NCT04419376 completednot on this mapstarted 2018, after this paper: background citation

Driving Pressure and Mortality: in the Pediatric Intensive Care Unit (PICU)

Typeobservational_patient_registrySponsorDr. Behcet Uz Children's HospitalRan2018 to 2020Enrolled116ConditionsARDS, Human, Respiratory FailureArmsdriving pressure
NCT06655805 recruitingnot on this mapstarted 2024, after this paper: background citation

Registry for Automated Mechanical VEntilation in Adults

Typeobservational_patient_registrySponsorHamilton Medical AGRan2024 to 2030Enrolled1,000ConditionsRespiratory Insufficiency Requiring Mechanical VentilationArmsNon-invasive ventilation, Invasive mechanical ventilation, high-flow nasal oxygen
3 · Its place in the literature

Who cites it

112 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Guideline
  4. Trial
  5. Trial
  6. Trial
  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. Article
  12. Management of Mechanical Ventilation in Emergency Medicine: A Scoping Review.Journal of the American College of Emergency Physicians open · 2026
    Review
  13. Review
  14. Review
  15. Observational
  16. Observational
  17. Review
  18. Review
  19. Article
  20. Article

52 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Ary Serpa Neto1Department of Intensive Care, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. 2Program of Post-Graduation, Research and Innovation, Faculdade de Medicina do ABC (FMABC), Santo André, Brazil. 3Department of Critical Care Medicine, Hospital Israelita Albert Einstein, São Paulo, Brazil. 4Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN. 5Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA. 6School of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. 7Department of Anaesthesia and Intensive Care Medicine, Helsinki University Hospital, Peijas Hospital, Vantaa, Finland. 8Medical School, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Brazil. 9Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA. 10Department of Anesthesiology and Intensive Care Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. 11Department of Surgical Sciences and Integrated Diagnostics, IRCCS San Martino IST, University of Genoa, Genoa, Italy. 12Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Fabienne D Simonis
Carmen S V Barbas
Michelle Biehl
Rogier M Determann
Jonathan Elmer
Gilberto Friedman
Ognjen Gajic
Joshua N Goldstein
Rita Linko
Roselaine Pinheiro de Oliveira
Sugantha Sundar
Daniel Talmor
Esther K Wolthuis
Marcelo Gama de Abreu
Paolo Pelosi
Marcus J Schultz
PROtective Ventilation Network Investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveProtective mechanical ventilation with low tidal volumes is standard of care for patients with acute respiratory distress syndrome. The aim of this individual patient data analysis was to determine the association between tidal volume and the occurrence of pulmonary complications in ICU patients without acute respiratory distress syndrome and the association between occurrence of pulmonary complications and outcome in these patients.

designIndividual patient data analysis. PATIENTS: ICU patients not fulfilling the consensus criteria for acute respiratory distress syndrome at the onset of ventilation.

interventionsMechanical ventilation with low tidal volume. MEASUREMENTS AND MAIN

resultsThe primary endpoint was development of a composite of acute respiratory distress syndrome and pneumonia during hospital stay. Based on the tertiles of tidal volume size in the first 2 days of ventilation, patients were assigned to a "low tidal volume group" (tidal volumes ≤ 7 mL/kg predicted body weight), an "intermediate tidal volume group" (> 7 and < 10 mL/kg predicted body weight), and a "high tidal volume group" (≥ 10 mL/kg predicted body weight). Seven investigations (2,184 patients) were included. Acute respiratory distress syndrome or pneumonia occurred in 23% of patients in the low tidal volume group, in 28% of patients in the intermediate tidal volume group, and in 31% of the patients in the high tidal volume group (adjusted odds ratio [low vs high tidal volume group], 0.72; 95% CI, 0.52-0.98; p = 0.042). Occurrence of pulmonary complications was associated with a lower number of ICU-free and hospital-free days and alive at day 28 (10.0 ± 10.9 vs 13.8 ± 11.6 d; p < 0.01 and 6.1 ± 8.1 vs 8.9 ± 9.4 d; p < 0.01) and an increased hospital mortality (49.5% vs 35.6%; p < 0.01).

conclusionsVentilation with low tidal volumes is associated with a lower risk of development of pulmonary complications in patients without acute respiratory distress syndrome.

Indexed as

FemaleHumansLung DiseasesMaleMiddle AgedRespiration, ArtificialRespiratory Distress SyndromeTidal Volume

Identifiers

PMID26181219

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.