Evidence map›Paper›PMID 26180973›Full record

ArticleAmerican journal of public health2015

Understanding Trends in Pertussis Incidence: An Agent-Based Model Approach.

Erinn Sanstead, Cynthia Kenyon, Seth Rowley, Eva Enns, Claudia Miller, Kristen Ehresmann, Shalini Kulasingam

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of public health, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Erinn SansteadErinn Sanstead, Seth Rowley, Shalini Kulasingam, and Eva Enns are with the School of Public Health, University of Minnesota, Minneapolis. Erinn Sanstead, Cynthia Kenyon, Seth Rowley, Claudia Miller, and Kristen Ehresmann are with the Division of Infectious Disease Epidemiology, Prevention, and Control, Minnesota Department of Health, St. Paul.
Cynthia KenyonErinn Sanstead, Seth Rowley, Shalini Kulasingam, and Eva Enns are with the School of Public Health, University of Minnesota, Minneapolis. Erinn Sanstead, Cynthia Kenyon, Seth Rowley, Claudia Miller, and Kristen Ehresmann are with the Division of Infectious Disease Epidemiology, Prevention, and Control, Minnesota Department of Health, St. Paul.
Seth RowleyErinn Sanstead, Seth Rowley, Shalini Kulasingam, and Eva Enns are with the School of Public Health, University of Minnesota, Minneapolis. Erinn Sanstead, Cynthia Kenyon, Seth Rowley, Claudia Miller, and Kristen Ehresmann are with the Division of Infectious Disease Epidemiology, Prevention, and Control, Minnesota Department of Health, St. Paul.
Eva EnnsErinn Sanstead, Seth Rowley, Shalini Kulasingam, and Eva Enns are with the School of Public Health, University of Minnesota, Minneapolis. Erinn Sanstead, Cynthia Kenyon, Seth Rowley, Claudia Miller, and Kristen Ehresmann are with the Division of Infectious Disease Epidemiology, Prevention, and Control, Minnesota Department of Health, St. Paul.
Claudia MillerErinn Sanstead, Seth Rowley, Shalini Kulasingam, and Eva Enns are with the School of Public Health, University of Minnesota, Minneapolis. Erinn Sanstead, Cynthia Kenyon, Seth Rowley, Claudia Miller, and Kristen Ehresmann are with the Division of Infectious Disease Epidemiology, Prevention, and Control, Minnesota Department of Health, St. Paul.
Kristen EhresmannErinn Sanstead, Seth Rowley, Shalini Kulasingam, and Eva Enns are with the School of Public Health, University of Minnesota, Minneapolis. Erinn Sanstead, Cynthia Kenyon, Seth Rowley, Claudia Miller, and Kristen Ehresmann are with the Division of Infectious Disease Epidemiology, Prevention, and Control, Minnesota Department of Health, St. Paul.
Shalini KulasingamErinn Sanstead, Seth Rowley, Shalini Kulasingam, and Eva Enns are with the School of Public Health, University of Minnesota, Minneapolis. Erinn Sanstead, Cynthia Kenyon, Seth Rowley, Claudia Miller, and Kristen Ehresmann are with the Division of Infectious Disease Epidemiology, Prevention, and Control, Minnesota Department of Health, St. Paul.
Minnesota Department of Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesWe examined the impact of undetected infections, adult immunity, and waning vaccine-acquired immunity on recent age-related trends in pertussis incidence.

methodsWe developed an agent-based model of pertussis transmission in Dakota County, Minnesota using case data from the Minnesota Department of Health. For outbreaks in 2004, 2008, and 2012, we fit our model to incidence in 3 children's age groups relative to adult incidence. We estimated parameters through model calibration.

resultsThe duration of vaccine-acquired immunity after completion of the 5-dose vaccination series decreased from 6.6 years in the 2004 model to approximately 3.0 years in the 2008 and 2012 models. Tdap waned after 2.1 years in the 2012 model. A greater percentage of adults were immune in the 2008 model than in the 2004 and 2012 models. On average, only 1 in 10 adult infections was detected, whereas 8 in 10 child infections were detected.

conclusionsThe observed trends in relative pertussis incidence in Dakota County can be attributed in part to fluctuations in adult immunity and waning vaccine-acquired immunity. No single factor accounts for current pertussis trends.

Indexed as

Age FactorsChildChild, PreschoolDiphtheria-Tetanus-acellular Pertussis VaccinesDisease OutbreaksHumansIncidenceInfantMinnesotaWhooping CoughYoung AdultDiphtheria-Tetanus-acellular Pertussis Vaccines

Identifiers

PMID26180973
PMCPMC4539800
OpenAlexW1778634203

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.