Evidence map›Paper›PMID 26180924›Full record

ArticleBritish journal of cancer2015

Are metformin, statin and aspirin use still associated with overall mortality among colorectal cancer patients with diabetes if adjusted for one another?

M M J Zanders, M P P van Herk-Sukel, P A J Vissers, R M C Herings, H R Haak, L V van de Poll-Franse

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 10 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 10 syntheses or guidelines pooled it, 49 citations in OpenAlex.

  1. Pooled it
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  3. Meta-analysis of aspirin-guided therapy of colorectal cancer.Journal of cancer research and clinical oncology · 2022
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  9. Metformin as an adjuvant treatment for cancer: a systematic review and meta-analysis.Annals of oncology : official journal of the European Society for Medical Oncology · 2016
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  18. Metformin selectively inhibits metastatic colorectal cancer with theProceedings of the National Academy of Sciences of the United States of America · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

M M J ZandersDepartment of Research, Netherlands Comprehensive Cancer Organisation, Eindhoven, The Netherlands.
M P P van Herk-SukelDepartment of Research, PHARMO Institute for Drug Outcomes Research, Utrecht, The Netherlands.
P A J Vissers1] Department of Research, Netherlands Comprehensive Cancer Organisation, Eindhoven, The Netherlands [2] Department of Medical and Clinical Psychology, Centre of Research on Psychology in Somatic Diseases (CoRPS), Tilburg University, Tilburg, The Netherlands.
R M C HeringsDepartment of Research, PHARMO Institute for Drug Outcomes Research, Utrecht, The Netherlands.
H R Haak1] Department of Internal Medicine, Máxima Medical Centre, Veldhoven, The Netherlands [2] Department of Internal Medicine, Division of General Internal Medicine, Maastricht University Medical Centre+, Maastricht, The Netherlands [3] Department of Health Services Research, CAPHRI School for Public Health and Primary Care, Maastricht University, Maastricht, The Netherlands.
L V van de Poll-Franse1] Department of Research, Netherlands Comprehensive Cancer Organisation, Eindhoven, The Netherlands [2] Department of Medical and Clinical Psychology, Centre of Research on Psychology in Somatic Diseases (CoRPS), Tilburg University, Tilburg, The Netherlands.
Netherlands Comprehensive Cancer Organisation · NLPharmo Institute · NLRadboud University Nijmegen · NLTilburg University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMetformin, statin and aspirin use seem associated with decreased mortality in cancer patients, though, without adjusting for one another. Independent associations of these drugs with overall mortality after colorectal cancer (CRC) diagnosis within glucose-lowering drugs (GLDs) users were assessed.

methodsPatients starting GLDs before CRC diagnosis (1998-2011) were selected from the Eindhoven Cancer Registry linked with the PHARMO Database Network. The Cox regression model, with time since CRC diagnosis, included time-dependent variables of cumulative exposure to metformin, statins and aspirin after cancer diagnosis and time-dependent ever-never terms for drug exposure.

resultsA total of 1043 patients used GLDs before CRC diagnosis; 666 (64%) used metformin, 639 (61%) used statins and 490 (47%) used aspirin after CRC diagnosis. Multivariable analyses revealed that longer cumulative exposure to metformin was not associated with overall mortality (HRCumulative exposure/6 months 1.02; 95% CI 0.97-1.07), whereas the favourable effect of statins increased with cumulative exposure (HRCumulative exposure/6 months 0.93; 95% CI 0.89-0.98). No association between aspirin use and overall mortality was seen (HRCumulative exposure/6 months 0.98; 95% CI 0.93-1.03).

conclusionsNo independent association between cumulative exposure to metformin, aspirin and overall mortality was found. Cumulative exposure to statins after CRC diagnosis was associated with lower overall mortality, supporting a drug effect of statins among GLDs users.

Indexed as

AgedAged, 80 and overAspirinColorectal NeoplasmsDiabetes ComplicationsDiabetes MellitusFemaleHumansHydroxymethylglutaryl-CoA Reductase InhibitorsHypoglycemic AgentsMaleMetforminMiddle AgedRegistriesRisk FactorsSurvival AnalysisAspirinHydroxymethylglutaryl-CoA Reductase InhibitorsHypoglycemic AgentsMetformin

Identifiers

PMID26180924
PMCPMC4522645
OpenAlexW1585462082

What OpenQuestion holds

Texttitle and abstract
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.