Evidence map›Paper›PMID 26180829›Full record

ArticleOpen forum infectious diseases2015

CD4 Response Up to 5 Years After Combination Antiretroviral Therapy in Human Immunodeficiency Virus-Infected Patients in Latin America and the Caribbean.

Paula M Luz, Pablo F Belaunzarán-Zamudio, Brenda Crabtree-Ramírez, Yanink Caro-Vega, Daniel Hoces, Peter F Rebeiro, Meridith Blevins, Jean W Pape, Claudia P Cortes, Denis Padgett and 5 more

Abstract read
In one paragraph

Article in Open forum infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Paula M LuzFundação Oswaldo Cruz , Instituto de Nacional de Infectologia Evandro Chagas , Rio de Janeiro , Brazil.
Pablo F Belaunzarán-ZamudioDepartment of Infectious Diseases , Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán.
Brenda Crabtree-RamírezDepartment of Infectious Diseases , Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán.
Yanink Caro-VegaDepartment of Infectious Diseases , Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán.
Daniel HocesInstituto de Medicina Tropical Alexander von Humboldt , Universidad Peruana Cayetano Heredia , Lima , Peru.
Peter F RebeiroVanderbilt University School of Medicine , Nashville, Tennessee.
Meridith BlevinsVanderbilt University School of Medicine , Nashville, Tennessee.
Jean W PapeDivision of Infectious Diseases, Department of Medicine , Weill Cornell Medical College , New York.
Claudia P CortesSchool of Medicine , University of Chile , Santiago.
Denis PadgettUniversidad Nacional Autónoma de Honduras , Tegucigalpa.
Pedro CahnFundación Huesped , Buenos Aires , Argentina.
Valdilea G VelosoFundação Oswaldo Cruz , Instituto de Nacional de Infectologia Evandro Chagas , Rio de Janeiro , Brazil.
Catherine C McGowanVanderbilt University School of Medicine , Nashville, Tennessee.
Beatriz GrinsztejnFundação Oswaldo Cruz , Instituto de Nacional de Infectologia Evandro Chagas , Rio de Janeiro , Brazil.
Bryan E ShepherdVanderbilt University School of Medicine , Nashville, Tennessee.

Funding

CCASAnet: Caribbean, Central and South America NetworkU01AI069923 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Pedro Enrique Cahn, Jessica L Castilho · 2006 to 2026
$41.6M
The FIOCRUZ Therapeutic and Prevention HIV/AIDS Clinical Trials Unit (FioTrials)UM1AI069476 · NIAID · FUNDACAO OSWALDO CRUZ · PI BEATRIZ GRINSZTEJN · 2012 to 2026
$26.3M
GHESKIO HIV Clinical Trial UnitUM1AI069421 · NIAID · GHESKIO CENTER · PI JEAN WILLIAM PAPE · 2012 to 2026
$23.6M
The FIOCRUZ Therapeutic and Prevention HIV/AIDS Clinical Trials Unit (FioTrials)U01AI069476 · NIAID · FUNDACAO OSWALDO CRUZ · PI GRINSZTEJN, BEATRIZ · 2008 to 2011
$14.0M
GHESKIO HIV Clinical Trial UnitU01AI069421 · NIAID · GHESKIO CENTER · PI PAPE, JEAN WILLIAM · 2007 to 2011
$8.4M
NIAID NIH HHS U01 AI069923NIAID NIH HHS UM1 AI069421NIAID NIH HHS UM1 AI069476
6 · The paper itself

Abstract

We describe CD4 counts at 6-month intervals for 5 years after combination antiretroviral therapy initiation among 12 879 antiretroviral-naive human immunodeficiency virus-infected adults from Latin America and the Caribbean. Median CD4 counts increased from 154 cells/mm(3) at baseline (interquartile range [IQR], 60-251) to 413 cells/mm(3) (IQR, 234-598) by year 5.

Indexed as

cARTcohortcombination antiretroviral therapyHIV/AIDSimmune recoveryinverse probability of censoring weightsLatin America and the Caribbean

Identifiers

PMID26180829
PMCPMC4498272

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.