Trial reportBioMed research international2015
Decreased Resting-State Interhemispheric Functional Connectivity in Parkinson's Disease.
Trial report in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Functional brain changes in Parkinson's disease: a whole brain ALE study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Pooled it
- Altered white matter microarchitecture in Parkinson's disease: a voxel-based meta-analysis of diffusion tensor imaging studies.Frontiers of medicine · 2021Pooled it
- Pallidal and subthalamic stimulations modulate inter-hemispheric interaction and asymmetry in Parkinson's disease.Molecular psychiatry · 2026Article
- Convergent reductions in interhemispheric functional, structural and callosal connectivity in Parkinson's disease.Frontiers in aging neuroscience · 2025Article
- Exploring brain asymmetry in early-stage Parkinson's disease through functional and structural MRI.CNS neuroscience & therapeutics · 2024Article
- Simulated brain networks reflecting progression of Parkinson's disease.Network neuroscience (Cambridge, Mass.) · 2024Article
- Interhemispheric imbalance and bradykinesia features in Parkinson's disease.Brain communications · 2024Article
- The Association of Retinal Microvasculature With Gray Matter Changes and Structural Covariance Network: A Voxel-Based Morphometry Study.Investigative ophthalmology & visual science · 2023Article
- Connectome-based modelling of neurodegenerative diseases: towards precision medicine and mechanistic insight.Nature reviews. Neuroscience · 2023Review
- Impaired Interhemispheric Synchrony in Parkinson's Disease with Fatigue.Journal of personalized medicine · 2022Article
- Altered Interhemispheric Functional Connectivity Associated With Early Verbal Fluency Decline After Deep Brain Stimulation in Parkinson's Disease.Frontiers in aging neuroscience · 2022Article
- Aberrant interhemispheric functional reciprocities of the default mode network and motor network in subcortical ischemic stroke patients with motor impairment: A longitudinal study.Frontiers in neurology · 2022Article
- Aberrant Volume-Wise and Voxel-Wise Concordance Among Dynamic Intrinsic Brain Activity Indices in Parkinson's Disease: A Resting-State fMRI Study.Frontiers in aging neuroscience · 2022Article
- Higher inter-hemispheric homotopic connectivity in lifelong premature ejaculation patients: a pilot resting-state fMRI study.Quantitative imaging in medicine and surgery · 2021Article
- Aberrant functional connectivity and activity in Parkinson's disease and comorbidity with depression based on radiomic analysis.Brain and behavior · 2021Article
- Functional connectivity of spoken language processing in early-stage Parkinson's disease: An MEG study.NeuroImage. Clinical · 2021Article
- Integrating Structural and Functional Interhemispheric Brain Connectivity of Gait Freezing in Parkinson's Disease.Frontiers in neurology · 2021Article
- Effective Connectivity During Rest and Music Listening: An EEG Study on Parkinson's Disease.Frontiers in aging neuroscience · 2021Article
- Prediction of Deep Brain Stimulation Outcome in Parkinson's Disease With Connectome Based on Hemispheric Asymmetry.Frontiers in neuroscience · 2021Article
- Altered Functional Segregated Sensorimotor, Associative, and Limbic Cortical-Striatal Connections in Parkinson's Disease: An fMRI Investigation.Frontiers in neurology · 2021Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAbnormalities in white matter integrity and specific functional network alterations have been increasingly reported in patients with Parkinson's disease (PD). However, little is known about the inter-hemispheric interaction in PD.
methodsFifty-one drug naive patients with PD and 51 age- and gender-matched healthy subjects underwent resting-state functional magnetic resonance imaging (rs-fMRI) scans. We compared the inter-hemispheric resting-state functional connectivity between patients with PD and healthy controls, using the voxel-mirrored homotopic connectivity (VMHC) approach. Then, we correlated the results from VMHC and clinical features in PD patients.
resultsRelative to healthy subject, patients exhibited significantly lower VMHC in putamen and cortical regions associated with sensory processing and motor control (involving sensorimotor and supramarginal cortex), which have been verified to play a critical role in PD. In addition, there were inverse relationships between the UPDRS motor scores and VMHC in the sensorimotor, and between the illness duration and VMHC in the supramarginal gyrus in PD patients.
conclusionsOur results suggest that the functional coordination between homotopic brain regions is impaired in PD patients, extending previous notions about the disconnection of corticostriatal circuit by providing new evidence supporting a disturbance in inter-hemispheric connections in PD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.