Evidence map›Paper›PMID 26180638›Full record

ArticleBMJ open respiratory research2015

Breastfeeding, lung volumes and alveolar size at school-age.

Cristian M Dogaru, Manjith Narayanan, Ben D Spycher, Anina M Pescatore, John Owers-Bradley, Caroline S Beardsmore, Michael Silverman, Claudia E Kuehni

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open respiratory research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Cristian M DogaruInstitute of Social and Preventive Medicine, University of Bern , Switzerland ; Department of Children, Young People and Education , University Campus Suffolk , UK.
Manjith NarayananDivision of Child Health, Department of Infection , Immunity & Inflammation, University of Leicester , UK.
Ben D SpycherInstitute of Social and Preventive Medicine, University of Bern , Switzerland.
Anina M PescatoreInstitute of Social and Preventive Medicine, University of Bern , Switzerland.
John Owers-BradleySchool of Physics and Astronomy, University of Nottingham , UK.
Caroline S BeardsmoreDivision of Child Health, Department of Infection , Immunity & Inflammation, University of Leicester , UK.
Michael SilvermanDivision of Child Health, Department of Infection , Immunity & Inflammation, University of Leicester , UK.
Claudia E KuehniInstitute of Social and Preventive Medicine, University of Bern , Switzerland.
University of Bern · CHUniversity of Leicester · GBUniversity of Nottingham · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

backgroundPrevious studies found larger lung volumes at school-age in formerly breastfed children, with some studies suggesting an effect modification by maternal asthma. We wanted to explore this further in children who had undergone extensive lung function testing. The current study aimed to assess whether breastfeeding was associated with larger lung volumes and, if so, whether all compartments were affected. We also assessed association of breastfeeding with apparent diffusion coefficient (ADC), which measures freedom of gas diffusion in alveolar-acinar compartments and is a surrogate of alveolar dimensions. Additionally, we assessed whether these effects were modified by maternal asthma.

methodsWe analysed data from 111 children and young adults aged 11-21 years, who had participated in detailed lung function testing, including spirometry, plethysmography and measurement of ADC of (3)Helium ((3)He) by MR. Information on breastfeeding came from questionnaires applied in early childhood (age 1-4 years). We determined the association between breastfeeding and these measurements using linear regression, controlling for potential confounders.

resultsWe did not find significant evidence for an association between duration of breastfeeding and lung volumes or alveolar dimensions in the entire sample. In breastfed children of mothers with asthma, we observed larger lung volumes and larger average alveolar size than in non-breastfed children, but the differences did not reach significance levels.

conclusionsConfirmation of effects of breastfeeding on lung volumes would have important implications for public health. Further investigations with larger sample sizes are warranted.

Indexed as

Paediatric asthma

Identifiers

PMID26180638
PMCPMC4499711
OpenAlexW1918064948

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.