ReviewF1000Research2015
Photoperiodic and circadian bifurcation theories of depression and mania.
Review in F1000Research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 47 citations in OpenAlex.
- The Ottawa sunglasses at night study: A randomized controlled trial of blue-blocking glasses for mania.Journal of affective disorders · 2026Trial
- Seasonal Mental Health Symptoms Amongst Former Criminal Legal System-Involved Adolescents.Journal of adolescence · 2026Article
- Mesolimbic dopamine neurons drive infradian rhythms in sleep-wake and heightened activity state.Science advances · 2025Article
- Impact of Autism on the Relation Between Sleep and Life Satisfaction in Japanese Adults.Diseases (Basel, Switzerland) · 2024Article
- Seasonal patterns of sickness absence due to diagnosed mental disorders: a nationwide 12-year register linkage study.Epidemiology and psychiatric sciences · 2023Article
- Psychological dominant stressor modification to an animal model of depression with chronic unpredictable mild stress.Veterinary world · 2023Article
- Birth, love, and fear: Physiological networks from pregnancy to parenthood.Comprehensive psychoneuroendocrinology · 2022Review
- Multi-Level Processes and Retina-Brain Pathways of Photic Regulation of Mood.Journal of clinical medicine · 2022Review
- Supersensitivity of Patients With Bipolar I Disorder to Light-Induced Phase Delay by Narrow Bandwidth Blue Light.Biological psychiatry global open science · 2022Article
- Complexity and variability analyses of motor activity distinguish mood states in bipolar disorder.PloS one · 2022Article
- Using Chronobiological Phenotypes to Address Heterogeneity in Bipolar Disorder.Molecular neuropsychiatry · 2020Review
- Diurnal variation of motor activity in adult ADHD patients analyzed with methods from graph theory.PloS one · 2020Article
- Pharmacological Manipulation of the Circadian Clock: A Possible Approach to the Management of Bipolar Disorder.CNS drugs · 2019Review
- Chris Cornell, the Black Hole Sun, and the Seasonality of Suicide.Neuropsychobiology · 2019Article
- Bipolar mood cycles associated with lunar entrainment of a circadian rhythm.Translational psychiatry · 2018Article
- Chronobiological theories of mood disorder.European archives of psychiatry and clinical neuroscience · 2018Review
- Circadian Rhythm Disturbances in Mood Disorders: Insights into the Role of the Suprachiasmatic Nucleus.Neural plasticity · 2017Review
- Article
- Advanced Circadian Phase in Mania and Delayed Circadian Phase in Mixed Mania and Depression Returned to Normal after Treatment of Bipolar Disorder.EBioMedicine · 2016Article
- When our body clocks run late: does it make us depressed?Annals of translational medicine · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Seasonal effects on mood have been observed throughout much of human history. Seasonal changes in animals and plants are largely mediated through the changing photoperiod (i.e., the photophase or duration of daylight). We review that in mammals, daylight specifically regulates SCN (suprachiasmatic nucleus) circadian organization and its control of melatonin secretion. The timing of melatonin secretion interacts with gene transcription in the pituitary pars tuberalis to modulate production of TSH (thyrotropin), hypothalamic T3 (triiodothyronine), and tuberalin peptides which modulate pituitary production of regulatory gonadotropins and other hormones. Pituitary hormones largely mediate seasonal physiologic and behavioral variations. As a result of long winter nights or inadequate illumination, we propose that delayed morning offset of nocturnal melatonin secretion, suppressing pars tuberalis function, could be the main cause for winter depression and even cause depressions at other times of year. Irregularities of circadian sleep timing and thyroid homeostasis contribute to depression. Bright light and sleep restriction are antidepressant and conversely, sometimes trigger mania. We propose that internal desynchronization or bifurcation of SCN circadian rhythms may underlie rapid-cycling manic-depressive disorders and perhaps most mania. Much further research will be needed to add substance to these theories.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.