ArticleInternational journal of preventive medicine2015
Inhibitory Effect of Genistein on PLC/PRF5 Hepatocellular Carcinoma Cell Line.
Article in International journal of preventive medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Inhibition of castration-resistant prostate cancer growth by genistein through suppression of AKR1C3.Food & nutrition research · 2023Article
- Genistein: An Integrative Overview of Its Mode of Action, Pharmacological Properties, and Health Benefits.Oxidative medicine and cellular longevity · 2021Review
- Epidemiologic Study of Gastric Cancer in Iran: A Systematic Review.Clinical and experimental gastroenterology · 2020Review
- High expression of ubiquitin carboxyl-terminal hydrolase 22 is associated with poor prognosis in hepatitis B virus-associated liver cancer.Oncology letters · 2019Article
- Effect of DNA Methyltransferase in Comparison to and in Combination with Histone Deacetylase Inhibitors on Hepatocellular Carcinoma HepG2 Cell LineAsian Pacific journal of cancer prevention : APJCP · 2019Article
- Inhibition of hepatocellular carcinoma cell proliferation, migration, and invasion by a disintegrin and metalloproteinase-17 inhibitor TNF484.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2019Article
- Effect of Genistein in Comparison with Trichostatin A on Reactivation of DNMTs Genes in Hepatocellular Carcinoma.Journal of clinical and translational hepatology · 2018Article
- Effect of Genistein on Apoptosis and Proliferation of Hepatocellular Carcinoma Hepa1-6 Cell Line.International journal of preventive medicine · 2018Article
- The Complex Puzzle of Interactions Among Functional Food, Gut Microbiota, and Colorectal Cancer.Frontiers in oncology · 2018Review
- Genistein and Trichostatin A Induction of Estrogen Receptor Alpha Gene Expression, Apoptosis and Cell Growth Inhibition in Hepatocellular Carcinoma HepG 2 CellsAsian Pacific journal of cancer prevention : APJCP · 2017Article
- Effects of Genistein and Synergistic Action in Combination with Tamoxifen on the HepG2 Human Hepatocellular Carcinoma Cell LineAsian Pacific journal of cancer prevention : APJCP · 2017Article
- Effect of Genistein and 17-β Estradiol on the Viability and Apoptosis of Human Hepatocellular Carcinoma HepG2 cell line.Advanced biomedical research · 2017Article
- Medicinal Plants, Effective Plant Compounds (Compositions) and their Effects on Stomach Cancer.International journal of preventive medicine · 2017Review
- Effect of Thymoquinone on P53 Gene Expression and Consequence Apoptosis in Breast Cancer Cell Line.International journal of preventive medicine · 2016Article
- Ovarian cancer risk and nonisoflavone flavonoids intake: A systematic review of epidemiological studies.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2016Review
- Role of superoxide dismutase in hepatitis B virus-related hepatocellular carcinoma.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2016Article
- Novel Investigations of Flavonoids as Chemopreventive Agents for Hepatocellular Carcinoma.BioMed research international · 2015Review
- A High Concentration of Genistein Induces Cell Death in Human Uterine Leiomyoma Cells by Autophagy.Expert opinion on environmental biologyArticle
- Diet Supplementation with Soy Protein Isolate, but Not the Isoflavone Genistein, Protects Against Alcohol-Induced Tumor Progression in DEN-Treated Male Mice.Advances in experimental medicine and biologyArticle
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8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNatural compounds including flavonoids like genistein (GE) are able to inhibit cell proliferation and induce apoptosis. GE is the main representative of these groups. GE inhibits carcinogenic tumors such as colon, stomach, lung, and pancreas tumors. The aim of the present study was to analyze the apoptotic effect of GE in the hepatocellular carcinoma (HCC) PLC/PRF5 cell line.
methodsCells were treated with various doses of GE (1, 5, 10, 25, 50, 75, and 100 μM/L) at different times (24, 48, and 72 h) and the MTT assay was commonly used. Furthermore, cells were treated with single dose of GE (25 μM) at different times and flow cytometry was performed.
resultsGE inhibited the growth of liver cancer cells significantly with a time- and dose-dependent manner. The percentage of living cells in GE treatment groups with a concentration of 25 μM at different times were 53, 48 and 47%, respectively (P < 0.001). Result of flow cytometry demonstrated that GE at a 25 μM concentration induces apoptosis significantly in a time-dependent manner. The percentage of apoptotic cells at different times were 44, 56, and 60%, respectively (P < 0.001).
conclusionsGE can significantly inhibit the growth of HCC cells and plays a significant role in apoptosis of this cell line.
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