Evidence map›Paper›PMID 26180594›Full record

ReviewOxidative medicine and cellular longevity2015

Biomarkers of Dietary Polyphenols in Cancer Studies: Current Evidence and Beyond.

Jincheng Wang, Lili Tang, Jia-Sheng Wang

Open access · hybridAbstract readReview
In one paragraph

Review in Oxidative medicine and cellular longevity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Androgen receptor and soy isoflavones in prostate cancer.Molecular and clinical oncology · 2019
    Review
  7. Article
  8. Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jincheng WangDepartment of Environmental Health Science, College of Public Health, University of Georgia, Athens, GA 30602, USA.
Lili TangDepartment of Environmental Health Science, College of Public Health, University of Georgia, Athens, GA 30602, USA.
Jia-Sheng WangDepartment of Environmental Health Science, College of Public Health, University of Georgia, Athens, GA 30602, USA.
University of Georgia · US

Funding

Chemoprevention of Green Tea Polyphenol on Liver CancerR01CA090997 · NCI · UNIVERSITY OF GEORGIA · PI WANG, JIA-SHENG · 2003 to 2007
$1.8M
Preparation for GTP long-term clinical study on bone healthU01AT006691 · NCCIH · TEXAS TECH UNIVERSITY HEALTH SCIS CENTER · PI SHEN, CHWAN-LI L · 2012 to 2013
$670k
Modulation of Oxidative Damage by Tea PolyphenolsR03ES011442 · NIEHS · TEXAS TECH UNIVERSITY HEALTH SCIS CENTER · PI WANG, JIA-SHENG · 2001 to 2002
$146k
NCCIH NIH HHS AT006691NCCIH NIH HHS U01 AT006691NCI NIH HHS CA90997NCI NIH HHS R01 CA090997NIEHS NIH HHS ES11442
6 · The paper itself

Abstract

Polyphenols, commonly contained in fruits and vegetables, have long been associated with a protective role against multiple diseases and adverse health effects. Generally, in vitro and animal experiments have provided strong positive evidence, whereas evidence from in vivo and human epidemiological studies is not strong enough. Most epidemiological studies to date use food frequency questionnaire based dietary intake estimations, which inevitably incur imprecision. Biomarkers of polyphenol have the potential to complement and enhance current studies. This review performed a literature search of all epidemiological studies or controlled clinical/intervention trials which employed biomarkers of exposure for polyphenols to help assess their anticarcinogenic role, using studies on green tea polyphenols as a study model. Currently, studies on this topic are still limited; breast cancer and prostate cancer were the only widely studied cancer types. Isoflavone is the only widely studied polyphenol. In addition to associations between polyphenols and cancer risks, factors such as host genetic susceptibility, epigenetic modification, and gut microbiome patterns may also impact on the protective roles of polyphenols. More evidence should be collected by utilizing biomarkers of exposure for polyphenols in future epidemiological studies before a clear conclusion can be made.

Indexed as

Biomarkers, TumorBreast NeoplasmsDietary SupplementsFemaleHumansMaleNeoplasmsPolyphenolsProstatic NeoplasmsBiomarkers, TumorPolyphenols

Identifiers

PMID26180594
PMCPMC4477246
OpenAlexW1559500462

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.