ArticleOxidative medicine and cellular longevity2015
Long Term Exposure to Polyphenols of Artichoke (Cynara scolymus L.) Exerts Induction of Senescence Driven Growth Arrest in the MDA-MB231 Human Breast Cancer Cell Line.
Article in Oxidative medicine and cellular longevity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 48 citations in OpenAlex.
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- Agroprospecting of Biowastes: Globe Artichoke (Molecules (Basel, Switzerland) · 2024Article
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- Flavonoids Regulate Redox-Responsive Transcription Factors in Glioblastoma and Microglia.Cells · 2023Article
- Bioactive Compounds from Artichoke and Application Potential.Food technology and biotechnology · 2023Review
- Comparative Estimation of the Cytotoxic Activity of Different Parts ofPharmaceutics · 2022Article
- Silver Nanoparticles Formulation of Flower Head's Polyphenols ofMolecules (Basel, Switzerland) · 2022Article
- Review
- Pro-Apoptotic Activity of Artichoke Leaf Extracts in Human HT-29 and RKO Colon Cancer Cells.International journal of environmental research and public health · 2021Article
- Identification ofNutrients · 2020Article
- Review
- Science and Healthy Meals in the World: Nutritional Epigenomics and Nutrigenetics of the Mediterranean Diet.Nutrients · 2020Review
- Anticancer effects induced by artichoke extract in oral squamous carcinoma cell lines.Journal of the Egyptian National Cancer Institute · 2020Article
- Artichoke Polyphenols Sensitize Human Breast Cancer Cells to Chemotherapeutic Drugs via a ROS-Mediated Downregulation of Flap Endonuclease 1.Oxidative medicine and cellular longevity · 2020Article
- Haplotype analysis of the germacrene A synthase gene and association with cynaropicrin content and biological activities in Cynara cardunculus.Molecular genetics and genomics : MGG · 2018Article
- Polyphenols as Promising Drugs against Main Breast Cancer Signatures.Antioxidants (Basel, Switzerland) · 2017Review
- Effect of Lactobacillus paracasei Culture Filtrates and Artichoke Polyphenols on Cytokine Production by Dendritic Cells.Nutrients · 2016Article
- Changes in Biomass, Mineral Composition, and Quality of Cardoon in Response to [Formula: see text]:Cl(-) Ratio and Nitrate Deprivation from the Nutrient Solution.Frontiers in plant science · 2016Article
- Polyphenols as Modulator of Oxidative Stress in Cancer Disease: New Therapeutic Strategies.Oxidative medicine and cellular longevity · 2016Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polyphenolic extracts from the edible part of artichoke (Cynara scolymus L.) have been shown to be potential chemopreventive and anticancer dietary compounds. High doses of polyphenolic extracts (AEs) induce apoptosis and decrease the invasive potential of the human breast cancer cell line, MDA-MB231. However, the molecular mechanism underlying AEs antiproliferative effects is not completely understood. We demonstrate that chronic and low doses of AEs treatment at sublethal concentrations suppress human breast cancer cell growth via a caspases-independent mechanism. Furthermore, AEs exposure induces a significant increase of senescence-associated β-galactosidase (SA-β-gal) staining and upregulation of tumour suppressor genes, p16(INK4a) and p21(Cip1/Waf1) in MDA-MB231 cells. AEs treatment leads to epigenetic alterations in cancer cells, modulating DNA hypomethylation and lysine acetylation levels in total proteins. Cell growth arrest correlates with increased reactive oxygen species (ROS) production in AEs treated breast cancer cells. Inhibition of ROS generation by N-acetylcysteine (NAC) attenuates the antiproliferative effect. These findings demonstrate that chronic AEs treatment inhibits breast cancer cell growth via the induction of premature senescence through epigenetic and ROS-mediated mechanisms. Our results suggest that artichoke polyphenols could be a promising dietary tool either in cancer chemoprevention or/and in cancer treatment as a nonconventional, adjuvant therapy.
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