ArticleCanadian geriatrics journal : CGJ2015
Psychosocial Risk Factors for Cognitive Decline in Late-Life Depression: Findings from the MTLD-III Study.
Article in Canadian geriatrics journal : CGJ, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neighborhood Environment and Cognition in Older Adults: A Systematic Review.American journal of preventive medicine · 2017Pooled it
- Risk Factors Influencing Cognitive Function in Elderly Patients With Late-Life Depression: A Scoping Review.Brain and behavior · 2025Article
- The association between neighborhood socioeconomic status, cardiovascular and cerebrovascular risk factors, and cognitive decline in the Health and Retirement Study (HRS).Aging & mental health · 2020Article
- Depressive Symptom Dimensions and Their Association with Hippocampal and Entorhinal Cortex Volumes in Community Dwelling Older Adults.Frontiers in aging neuroscience · 2018Article
- Summer Issue 2015.Canadian geriatrics journal : CGJ · 2015Article
- Impact of sociodemographic variables on executive functions.Dementia & neuropsychologiaArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundCognitive impairment and depression frequently co-occur in late life. There remains a need to better characterize psychosocial risk factors of cognitive decline in older adults with depression. We hypothesized that certain psychosocial factors would be associated with higher risk of cognitive decline in individuals with late-life depression.
methods130 individuals aged ≥ 65 years who had achieved remission from a major depressive episode were randomized to donepezil or placebo and then closely followed for two years. Using Cox proportional hazard models, we examined the association between baseline median household income, education level, race, marital status, and social support and cognitive decline over the follow-up.
resultsLower interpersonal support (OR = 0.86 [0.74-0.99], p = .04) and lower baseline global neuropsychological score (OR = 0.56 [0.36-0.87], p = .001) predicted shorter time to conversion to MCI or dementia in univariate models. These exposures did not remain significant in multivariate analyses. Neither socioeconomic status nor other psychosocial factors independently predicted cognitive diagnostic conversion (p > .05).
conclusionsWe did not find reliable associations between cognitive outcome and any of the psychosocial factors examined. Future large-scale, epidemiological studies, ideally using well-validated subjective measures, should better characterize psychosocial risk factors for cognitive decline in late-life depression.
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