ArticleInternational journal of endocrinology2015
Leptin as well as Free Leptin Receptor Is Associated with Polycystic Ovary Syndrome in Young Women.
Article in International journal of endocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- Review
- Role of vitamin D and leptin levels in PCOS in young women: A family medicine perspective.Journal of family medicine and primary care · 2024Article
- Reproductive neuroendocrine defects programmed by prenatal testosterone treatment between gestational days 60-90 are amplified by postnatal obesity in sheep.Frontiers in physiology · 2024Article
- Insulin resistance in polycystic ovary syndrome across various tissues: an updated review of pathogenesis, evaluation, and treatment.Journal of ovarian research · 2023Review
- Expression of nutrient transporters in placentas affected by gestational diabetes: role of leptin.Frontiers in endocrinology · 2023Review
- Review
- Markers of insulin resistance in Polycystic ovary syndrome women: An update.World journal of diabetes · 2022Review
- Elevated Serum Leptin Levels as a Predictive Marker for Polycystic Ovary Syndrome.Frontiers in endocrinology · 2022Article
- Article
- Article
- The Anti-Inflammatory Effects of Testosterone.Journal of the Endocrine Society · 2019Review
- Leptin resistance: underlying mechanisms and diagnosis.Diabetes, metabolic syndrome and obesity : targets and therapy · 2019Review
- Leptin action in normal and pathological pregnancies.Journal of cellular and molecular medicine · 2018Review
- Genetics of PCOS: A systematic bioinformatics approach to unveil the proteins responsible for PCOS.Genomics data · 2016Article
- The Deep Correlation between Energy Metabolism and Reproduction: A View on the Effects of Nutrition for Women Fertility.Nutrients · 2016Review
- Circulating Levels of Vitamin DJournal of human reproductive sciencesArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Aim. Leptin has two forms in the circulation: free and bound forms. The soluble leptin receptor (sOB-R) circulates in the blood and can bind to leptin. The aim of this study is to assess the concentrations of the leptin and the sOB-R in PCOS and its relation to adiposity, insulin resistance, and androgens. Methods. A cross-sectional study included 78 female students aged 17-25 years. Fasting serum leptin and sOB-R concentrations were measured. The anthropometric variables and the hormonal profile such as insulin, female and male sex hormones, and prolactin were assessed. Results. In PCOS, leptin level (ng/ml) and free leptin index (FLI) increased significantly while sOB-R (ng/ml) significantly decreased compared to control subjects. In age-matched subjects, obese PCOS had increased leptin level in ng/ml (median level with interquartile levels) of 45.67 (41.98-48.04) and decreased sOB-R in ng/ml 11.47 (7.59-16.44) compared to lean PCOS 16.97 (10.60-45.55) for leptin and 16.62 (11.61-17.96) for sOB-R with p values 0.013 and 0.042, respectively. However, body mass index (BMI) is significantly correlated with leptin and s-OBR, while no significant correlations with parameters of insulin resistance were detected. Conclusion. PCOS is associated with hyperleptinemia and increased free leptin index. Decreased sOB-R could be a compensatory mechanism for the defective action of leptin.
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Registered trials
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