ArticleLung India : official organ of Indian Chest Society
Exercise-induced desaturation in patients with chronic obstructive pulmonary disease on six-minute walk test.
Article in Lung India : official organ of Indian Chest Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 20 citations in OpenAlex.
- Portable low-flow nasal oxygen versus ambient air in patients with chronic lung disease and exercise-induced hypoxaemia: a randomised controlled crossover non-inferiority trial.BMJ open respiratory research · 2026Trial
- Development of a Screening Model for Exercise-Induced Desaturation by Machine Learning Method.Tuberculosis and respiratory diseases · 2026Article
- Performance of Wearable Pulse Oximetry During Controlled Hypoxia Induction: Instrument Validation Study.JMIR formative research · 2026Article
- Prevalence of Exercise-Induced Desaturation Among COPD Patients Enrolled in Early Inpatient Pulmonary Rehabilitation.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2026Article
- The desat-max in 2-chair test appears to be a worthwhile parameter to identify sickness: An appraisal.The Indian journal of medical research · 2025Article
- Characteristics and Quality of Life of Patients with COPD with Different Degrees of Exercise-Induced Desaturation on Six-minute Walk Test.International journal of chronic obstructive pulmonary disease · 2025Article
- Heart Rate Variability and Peripheral Oxygen Saturation Levels in Chronic Obstructive Pulmonary Disease.Cureus · 2025Article
- Evaluation of novel indices of walking performance taking oxygen desaturation into account during six-minute walk test in cardiovascular disease patients.Heart and vessels · 2024Article
- Functional Exercise Capacity and Perceived Exertion in Patients with Empty Nose Syndrome.Diagnostics (Basel, Switzerland) · 2024Article
- Assessment of the feasibility of 1-min sit-to-stand test in evaluating functional exercise capacity in interstitial lung disease patients.Journal of exercise rehabilitation · 2023Article
- Article
- Two chair test: a substitute of 6 min walk test appear cardiopulmonary reserve specific.BMJ open respiratory research · 2020Article
- SaOInternational journal of chronic obstructive pulmonary disease · 2019Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesExercise-induced desaturation (EID) is associated with increased mortality in chronic obstructive pulmonary disease (COPD). However, the relationship of EID with anthropometric and clinical parameters of resting pulmonary function test and six-minute walk test (6MWT) in COPD remains unclear. The study was designed to assess the correlate of EID and to identify various possible predictors of EID in stable normoxemic patients of COPD. MATERIALS AND
methodsSixty patients with stable COPD diagnosed and staged as per the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines underwent 6MWT. A drop in standard pulse oximetry (SpO2) of ≥4% or nadir up to ≤88% was defined as EID. Based on EID during 6MWT, two groups were formed: desaturators (DS) and nondesaturators (NDS). DS and NDS were compared for baseline and clinical characters by the Student's t-test while Pearson and Spearman rho correlation coefficient assessed strength of the association of anthropometric and clinical variables with EID. The predictors of EID were identified by logistic regression and receiver operator curve analysis.
resultOut of 60 patients with stable COPD, 33 patients desaturated on exercise (n = 33/60). DS had significantly lower values of FEV1 (P < 0.001), FVC (P < 0.01) FEV1/FVC (P < 0.01) compared to NDS. EID had significant negative correlation with FEV1 (r = 0.31, P < 0.01), resting oxygen saturation (r = 0.549, P < 0.001) and 6MWD (r = 0.511, P < 0.001). Resting SpO2 ≤93% was found to a predictor of EID with a sensitivity and specificity of 83% and 78%, respectively. INTERPRETATION AND
conclusionThe 6MWT is a safe and sensitive test to recognize EID in normoxic stable COPD patients. Resting oxygen saturation is a good predictor of EID.
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