Evidence map›Paper›PMID 26180255›Full record

SynthesisNutrition reviews2015

Effect of vitamin D supplementation alone or with calcium on adiposity measures: a systematic review and meta-analysis of randomized controlled trials.

Paulette D Chandler, Lu Wang, Xi Zhang, Howard D Sesso, Manickavasagar V Moorthy, Obiageli Obi, Joshua Lewis, Richard L Prince, Jacqueline S Danik, JoAnn E Manson and 2 more

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nutrition reviews, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Paulette D ChandlerP.D. Chandler, L. Wang, H.D. Sesso, M.V. Moorthy, J.S. Danik, J.E. Manson, and Y. Song are with the Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. X. Zhang and Y. Song are with the Department of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, Indiana, USA. H.D. Sesso and J.E. Manson are with the Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. O. Obi is with the Boston University School of Public Health, Boston, Massachusetts, USA. J. Lewis and R.L. Prince are with the School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia. J. Lewis and R.L. Prince are with the Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia. R.L. Prince is with the School of Public Health, Curtin University, Perth, Western Australia, Australia. J.S. Danik is with the Cardiovascular Division, Mount Sinai St. Luke's Hospital, New York, New York, USA. M.S. LeBoff is with the Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. pchandler@partners.org.
Lu WangP.D. Chandler, L. Wang, H.D. Sesso, M.V. Moorthy, J.S. Danik, J.E. Manson, and Y. Song are with the Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. X. Zhang and Y. Song are with the Department of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, Indiana, USA. H.D. Sesso and J.E. Manson are with the Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. O. Obi is with the Boston University School of Public Health, Boston, Massachusetts, USA. J. Lewis and R.L. Prince are with the School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia. J. Lewis and R.L. Prince are with the Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia. R.L. Prince is with the School of Public Health, Curtin University, Perth, Western Australia, Australia. J.S. Danik is with the Cardiovascular Division, Mount Sinai St. Luke's Hospital, New York, New York, USA. M.S. LeBoff is with the Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Xi ZhangP.D. Chandler, L. Wang, H.D. Sesso, M.V. Moorthy, J.S. Danik, J.E. Manson, and Y. Song are with the Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. X. Zhang and Y. Song are with the Department of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, Indiana, USA. H.D. Sesso and J.E. Manson are with the Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. O. Obi is with the Boston University School of Public Health, Boston, Massachusetts, USA. J. Lewis and R.L. Prince are with the School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia. J. Lewis and R.L. Prince are with the Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia. R.L. Prince is with the School of Public Health, Curtin University, Perth, Western Australia, Australia. J.S. Danik is with the Cardiovascular Division, Mount Sinai St. Luke's Hospital, New York, New York, USA. M.S. LeBoff is with the Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Howard D SessoP.D. Chandler, L. Wang, H.D. Sesso, M.V. Moorthy, J.S. Danik, J.E. Manson, and Y. Song are with the Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. X. Zhang and Y. Song are with the Department of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, Indiana, USA. H.D. Sesso and J.E. Manson are with the Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. O. Obi is with the Boston University School of Public Health, Boston, Massachusetts, USA. J. Lewis and R.L. Prince are with the School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia. J. Lewis and R.L. Prince are with the Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia. R.L. Prince is with the School of Public Health, Curtin University, Perth, Western Australia, Australia. J.S. Danik is with the Cardiovascular Division, Mount Sinai St. Luke's Hospital, New York, New York, USA. M.S. LeBoff is with the Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Manickavasagar V MoorthyP.D. Chandler, L. Wang, H.D. Sesso, M.V. Moorthy, J.S. Danik, J.E. Manson, and Y. Song are with the Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. X. Zhang and Y. Song are with the Department of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, Indiana, USA. H.D. Sesso and J.E. Manson are with the Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. O. Obi is with the Boston University School of Public Health, Boston, Massachusetts, USA. J. Lewis and R.L. Prince are with the School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia. J. Lewis and R.L. Prince are with the Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia. R.L. Prince is with the School of Public Health, Curtin University, Perth, Western Australia, Australia. J.S. Danik is with the Cardiovascular Division, Mount Sinai St. Luke's Hospital, New York, New York, USA. M.S. LeBoff is with the Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Obiageli ObiP.D. Chandler, L. Wang, H.D. Sesso, M.V. Moorthy, J.S. Danik, J.E. Manson, and Y. Song are with the Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. X. Zhang and Y. Song are with the Department of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, Indiana, USA. H.D. Sesso and J.E. Manson are with the Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. O. Obi is with the Boston University School of Public Health, Boston, Massachusetts, USA. J. Lewis and R.L. Prince are with the School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia. J. Lewis and R.L. Prince are with the Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia. R.L. Prince is with the School of Public Health, Curtin University, Perth, Western Australia, Australia. J.S. Danik is with the Cardiovascular Division, Mount Sinai St. Luke's Hospital, New York, New York, USA. M.S. LeBoff is with the Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Joshua LewisP.D. Chandler, L. Wang, H.D. Sesso, M.V. Moorthy, J.S. Danik, J.E. Manson, and Y. Song are with the Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. X. Zhang and Y. Song are with the Department of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, Indiana, USA. H.D. Sesso and J.E. Manson are with the Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. O. Obi is with the Boston University School of Public Health, Boston, Massachusetts, USA. J. Lewis and R.L. Prince are with the School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia. J. Lewis and R.L. Prince are with the Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia. R.L. Prince is with the School of Public Health, Curtin University, Perth, Western Australia, Australia. J.S. Danik is with the Cardiovascular Division, Mount Sinai St. Luke's Hospital, New York, New York, USA. M.S. LeBoff is with the Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Richard L PrinceP.D. Chandler, L. Wang, H.D. Sesso, M.V. Moorthy, J.S. Danik, J.E. Manson, and Y. Song are with the Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. X. Zhang and Y. Song are with the Department of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, Indiana, USA. H.D. Sesso and J.E. Manson are with the Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. O. Obi is with the Boston University School of Public Health, Boston, Massachusetts, USA. J. Lewis and R.L. Prince are with the School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia. J. Lewis and R.L. Prince are with the Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia. R.L. Prince is with the School of Public Health, Curtin University, Perth, Western Australia, Australia. J.S. Danik is with the Cardiovascular Division, Mount Sinai St. Luke's Hospital, New York, New York, USA. M.S. LeBoff is with the Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Jacqueline S DanikP.D. Chandler, L. Wang, H.D. Sesso, M.V. Moorthy, J.S. Danik, J.E. Manson, and Y. Song are with the Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. X. Zhang and Y. Song are with the Department of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, Indiana, USA. H.D. Sesso and J.E. Manson are with the Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. O. Obi is with the Boston University School of Public Health, Boston, Massachusetts, USA. J. Lewis and R.L. Prince are with the School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia. J. Lewis and R.L. Prince are with the Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia. R.L. Prince is with the School of Public Health, Curtin University, Perth, Western Australia, Australia. J.S. Danik is with the Cardiovascular Division, Mount Sinai St. Luke's Hospital, New York, New York, USA. M.S. LeBoff is with the Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
JoAnn E MansonP.D. Chandler, L. Wang, H.D. Sesso, M.V. Moorthy, J.S. Danik, J.E. Manson, and Y. Song are with the Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. X. Zhang and Y. Song are with the Department of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, Indiana, USA. H.D. Sesso and J.E. Manson are with the Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. O. Obi is with the Boston University School of Public Health, Boston, Massachusetts, USA. J. Lewis and R.L. Prince are with the School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia. J. Lewis and R.L. Prince are with the Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia. R.L. Prince is with the School of Public Health, Curtin University, Perth, Western Australia, Australia. J.S. Danik is with the Cardiovascular Division, Mount Sinai St. Luke's Hospital, New York, New York, USA. M.S. LeBoff is with the Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Meryl S LeBoffP.D. Chandler, L. Wang, H.D. Sesso, M.V. Moorthy, J.S. Danik, J.E. Manson, and Y. Song are with the Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. X. Zhang and Y. Song are with the Department of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, Indiana, USA. H.D. Sesso and J.E. Manson are with the Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. O. Obi is with the Boston University School of Public Health, Boston, Massachusetts, USA. J. Lewis and R.L. Prince are with the School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia. J. Lewis and R.L. Prince are with the Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia. R.L. Prince is with the School of Public Health, Curtin University, Perth, Western Australia, Australia. J.S. Danik is with the Cardiovascular Division, Mount Sinai St. Luke's Hospital, New York, New York, USA. M.S. LeBoff is with the Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Yiqing SongP.D. Chandler, L. Wang, H.D. Sesso, M.V. Moorthy, J.S. Danik, J.E. Manson, and Y. Song are with the Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. X. Zhang and Y. Song are with the Department of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, Indiana, USA. H.D. Sesso and J.E. Manson are with the Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. O. Obi is with the Boston University School of Public Health, Boston, Massachusetts, USA. J. Lewis and R.L. Prince are with the School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia. J. Lewis and R.L. Prince are with the Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia. R.L. Prince is with the School of Public Health, Curtin University, Perth, Western Australia, Australia. J.S. Danik is with the Cardiovascular Division, Mount Sinai St. Luke's Hospital, New York, New York, USA. M.S. LeBoff is with the Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Funding

Quality Assurance and Quality Control Project Management: Improving Submissions and Study Conduct in the Human Subjects Research Prior Approval ProcessUL1TR002529 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M, WIEHE, SARAH ELIZABETH · 2018 to 2022
$27.2M
VITamin D and omegA-3 triaL (VITAL)U01CA138962 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., MANSON, JOANN ELISABETH · 2009 to 2014
$23.6M
Indiana Clinical and Translational Sciences InstituteUL1TR001108 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$23.3M
The VITamin D and OmegA-3 TriaL (VITAL)R01CA138962 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., MANSON, JOANN ELISABETH · 2015 to 2019
$20.9M
VITamin D and OmegA-3 TriaL (VITAL): Interrelationship of Vitamin D and Vitamin K on BoneR01AR059775 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI LEBOFF, MERYL SUSAN · 2012 to 2022
$3.9M
Effect of Vitamin D and Omega-3 Fatty Acids on Blood Pressure and HypertensionR01HL102122 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI FORMAN, JOHN P, SESSO, HOWARD D · 2011 to 2016
$3.3M
Diabetes Prevention in the Vitamin D and Omega-3 TrialR01DK088078 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI PRADHAN, ARUNA DAS, SONG, YIQING · 2010 to 2014
$2.4M
Racial/Ethnic Differences in 25(OH)D and PTH Levels and CVD among WomenR01HL113056 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI SONG, YIQING · 2013 to 2016
$1.8M
Vitamin D Status, Vitamin D Receptor Gene Variants, and Hypertension RiskR00HL095649 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI WANG, LU · 2012 to 2014
$729k
Vitamin D Status, Vitamin D Receptor Gene Variants, and Hypertension RiskK99HL095649 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI WANG, LU · 2010 to 2011
$179k
NCATS NIH HHS UL1 TR001108NCI NIH HHS 3U01CA138962-05S1NCI NIH HHS R01 CA138962NCI NIH HHS U01 CA138962NCI NIH HHS U01CA138962NHLBI NIH HHS K99 HL095649NHLBI NIH HHS R00 HL095649NHLBI NIH HHS R00-HL095649NHLBI NIH HHS R01 HL102122NHLBI NIH HHS R01 HL113056NHLBI NIH HHS R01-HL113056NIAMS NIH HHS R01 AR059775NIDDK NIH HHS R01 DK088078NIDDK NIH HHS R01-DK088078
6 · The paper itself

Abstract

contextThe independent or interactive effects of vitamin D and calcium on adiposity remain inconclusive.

objectiveThe objective of this systematic review and meta-analysis was to assess whether vitamin D and calcium supplements cause changes in adiposity. DATA SOURCES: MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials databases were searched for literature published from 1966 to March 2014. STUDY SELECTION: A systematic search was conducted for randomized clinical trials with ≥ 50 participants aged ≥ 18 years at baseline who had received at least 12 weeks of treatment. Among the inclusion criteria were supplementation with vitamin D with or without calcium and measurement of adiposity (weight, body mass index [BMI], and/or fat mass). DATA EXTRACTION: The primary endpoints assessed were changes in weight, BMI, or fat mass. DATA SYNTHESIS: Of 953 trials identified, 26 randomized clinical trials (n = 12, vitamin D alone; n = 10, vitamin D plus calcium versus calcium control; n = 4, vitamin D plus calcium versus placebo) with a total of 42,430 participants (median duration, 12 months) met the inclusion criteria. When compared with placebo, vitamin D supplementation had no significant effect on BMI (weighted mean difference [WMD], -0.06 kg/m(2); 95% confidence interval [95%CI], -0.14 to 0.03), weight (WMD, -0.05 kg; 95%CI, -0.32 to 0.23), or fat mass (WMD, -0.43 kg; 95%CI, -1.69 to 0.84). Likewise, no significant reduction in BMI (WMD, 0.02 kg/m(2); 95%CI, -0.11 to 0.14), weight (WMD, 0.12 kg; 95%CI, -0.24 to 0.49), or fat mass (WMD, 0.12 kg; 95%CI, -0.22 to 0.45) was observed in participants who received vitamin D plus calcium compared with those who received calcium control.

conclusionsSupplementation with vitamin D showed no effect on adiposity measures in adults.

Indexed as

Dietary SupplementsAdiposityBody Mass IndexBody WeightCalciumHumansObesityRandomized Controlled Trials as TopicVitamin DVitaminsCalciumVitamin DVitaminsadiposityobesitysupplementationvitamin D

Identifiers

PMID26180255
PMCPMC4537389

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