Evidence map›Paper›PMID 26180221›Full record

Trial reportNicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco2015

Correlates of Adherence to Varenicline Among HIV+ Smokers.

Donna Shelley, Tuo-Yen Tseng, Mirelis Gonzalez, Paul Krebs, Selena Wong, Robert Furberg, Scott Sherman, Antoinette Schoenthaler, Anthony Urbina, Charles M Cleland

Abstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Interventions for tobacco use cessation in people living with HIV.The Cochrane database of systematic reviews · 2024
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Interventions for tobacco use cessation in people living with HIV and AIDS.The Cochrane database of systematic reviews · 2016
    Pooled it
  6. Mobile phone-based interventions for smoking cessation.The Cochrane database of systematic reviews · 2016
    Pooled it
  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. Adherence and Efficacy of Smoking Cessation Treatment Among Patients with COPD in China.International journal of chronic obstructive pulmonary disease
    Trial
  12. Review
  13. Article
  14. Attitudes and practices of health care providers towards improving adherence to smoking cessation medications in Australia: A descriptive study.Health promotion journal of Australia : official journal of Australian Association of Health Promotion Professionals · 2023
    Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Adherence to Pharmacological Smoking Cessation Interventions: A Literature Review and Synthesis of Correlates and Barriers.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Donna ShelleyDepartment of Population Health, New York University School of Medicine, New York, NY; donna.shelley@nyumc.org.
Tuo-Yen TsengDepartment of Population Health, New York University School of Medicine, New York, NY;
Mirelis GonzalezDepartment of Population Health, New York University School of Medicine, New York, NY;
Paul KrebsDepartment of Population Health, New York University School of Medicine, New York, NY;
Selena WongDepartment of Population Health, New York University School of Medicine, New York, NY;
Robert FurbergCenter for the Advancement of Health Information Technology, Research Triangle Institute, Raleigh, NC;
Scott ShermanDepartment of Population Health, New York University School of Medicine, New York, NY; Behavioral Health Research, St Luke's Roosevelt Hospital, New York, NY;
Antoinette SchoenthalerDepartment of Population Health, New York University School of Medicine, New York, NY;
Anthony UrbinaNew York University College of Nursing and Center for Drug Use and HIV Research, New York, NY.
Charles M ClelandNew York University College of Nursing and Center for Drug Use and HIV Research, New York, NY.

Funding

Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ADRIANA HEGUY · 1985 to 2026
$83.1M
Transdisciplinary Theoretical Svnthesis and Development CoreP30DA011041 · NIDA · NEW YORK UNIVERSITY · PI Holly Hagan · 1998 to 2026
$38.9M
Improving adherence to smoking cessation medication among PLWHAR34DA031636 · NIDA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SHELLEY, DONNA R · 2012 to 2013
$764k
NCI NIH HHS P30 CA016087NIDA NIH HHS 15R34DA031636-02NIDA NIH HHS P30 DA011041NIDA NIH HHS R34 DA031636
6 · The paper itself

Abstract

introductionLow rates of adherence to smoking cessation pharmacotherapy may limit the effectiveness of treatment. However, few studies have examined adherence in smoking cessation trials thus, there is a limited understanding of factors that influence adherence behaviors. This brief report analyzes correlates of adherence to varenicline among people living with HIV/AIDS.

methodsStudy participants were recruited from three HIV care centers in New York City and enrolled in a three-arm randomized controlled pilot study in which all subjects received varenicline. At the 1-month study visit, there were no significant differences in adherence by study condition, therefore we combined treatment arms to examine correlates of adherence (n = 127). We used pill counts to assess varenicline adherence, defined as taking at least 80% of the prescribed dose. We conducted a multivariate path analysis to assess factors proposed by the information-motivation-behavioral skills model to predict adherence.

resultsOnly 56% of smokers were at least 80% adherent to varenicline at 1 month. Adherence-related information, self-efficacy, a college degree, and non-Hispanic white race/ethnicity were associated with increased varenicline adherence. In path analysis, information and motivation were associated with increased adherence self-efficacy, and adherence self-efficacy was associated with increased adherence, but with marginal significance. These associations with adherence were no longer significant after controlling for race/ethnicity and education.

conclusionsFurther exploration of the role of a modifiable correlates of adherence, such as adherence-related information, motivation and self-efficacy is warranted. Interventions are needed that can address disparities in these and other psychosocial factors that may mediate poor medication adherence.

Indexed as

HIV InfectionsMedication AdherenceFemaleHumansMaleMiddle AgedNew York CityNicotinic AgonistsPilot ProjectsSmoking CessationVareniclineNicotinic AgonistsVarenicline

Identifiers

PMID26180221
PMCPMC4580547

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.