ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Sleep Deprivation Impairs the Human Central and Peripheral Nervous System Discrimination of Social Threat.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed.
- Examining fronto-limbic brain and sleep mechanisms of antidepressant effects in cognitive-behavioral therapy for insomnia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Trial
- Impact of Prescribed and Self-Selected Music Interventions on Stress, Sleep, Heart Rate Variability, and Brain Connectivity in Surgeons Using 7-Tesla Functional Magnetic Resonance Imaging and Wearable Actigraphy: Multimodal Feasibility Randomized Controlled Trial.JMIR formative research · 2026Trial
- Targeted limbic self-neuromodulation for alleviating central sensitization symptoms in fibromyalgia.BMC medicine · 2025Trial
- Trial
- Human tau pathology is associated with lonely, nontraveling slow waves linked to memory impairment.Nature neuroscience · 2026Article
- Shorter sleep duration predicts altered next-day physiologic, behavioral, and corticolimbic responses during fear extinction recall in youth.Neurobiology of learning and memory · 2026Article
- The categorical effect of negative emotion on memory before and after sleep deprivation.Neuropsychologia · 2025Article
- Daily sleep, social encounters, and momentary loneliness in late life.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- Article
- Sleep Deprivation Selectively Impairs Interpersonal Trust in Different Social Scenarios: Evidence from the Social Mindfulness Paradigm.Nature and science of sleep · 2025Article
- The relationship between trait anxiety and sleep quality in college students: an exploratory analysis of physical activity as a moderator.Frontiers in psychiatry · 2025Article
- The new science of sleep: From cells to large-scale societies.PLoS biology · 2024Article
- From trenches to technology: a narrative review of sleep medicine in the military.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Review
- Insufficient Sleep and Behavioral Health in the Military: A 5-Country Perspective.Current psychiatry reports · 2024Review
- Sleep and Socioemotional Outcomes Among Sexual and Gender Minority Adolescents: A Longitudinal Study.Archives of sexual behavior · 2024Article
- Socioeconomic factors, sleep timing and duration, and amygdala resting-state functional connectivity in children.Frontiers in psychiatry · 2024Article
- Sleep disorders and cancer incidence: examining duration and severity of diagnosis among veterans.Frontiers in oncology · 2024Article
- A precision neuroscience approach to estimating reliability of neural responses during emotion processing: Implications for task-fMRI.NeuroImage · 2024Article
- Associations between sleep quality and irritability: Testing the mediating role of emotion regulation.Personality and individual differences · 2023Article
- The Impact of Sleep Deprivation on Brain Networks in Response to Social Evaluation Tasks.Brain sciences · 2023Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Facial expressions represent one of the most salient cues in our environment. They communicate the affective state and intent of an individual and, if interpreted correctly, adaptively influence the behavior of others in return. Processing of such affective stimuli is known to require reciprocal signaling between central viscerosensory brain regions and peripheral-autonomic body systems, culminating in accurate emotion discrimination. Despite emerging links between sleep and affective regulation, the impact of sleep loss on the discrimination of complex social emotions within and between the CNS and PNS remains unknown. Here, we demonstrate in humans that sleep deprivation impairs both viscerosensory brain (anterior insula, anterior cingulate cortex, amygdala) and autonomic-cardiac discrimination of threatening from affiliative facial cues. Moreover, sleep deprivation significantly degrades the normally reciprocal associations between these central and peripheral emotion-signaling systems, most prominent at the level of cardiac-amygdala coupling. In addition, REM sleep physiology across the sleep-rested night significantly predicts the next-day success of emotional discrimination within this viscerosensory network across individuals, suggesting a role for REM sleep in affective brain recalibration. Together, these findings establish that sleep deprivation compromises the faithful signaling of, and the "embodied" reciprocity between, viscerosensory brain and peripheral autonomic body processing of complex social signals. Such impairments hold ecological relevance in professional contexts in which the need for accurate interpretation of social cues is paramount yet insufficient sleep is pervasive.
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