ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Aberrant Salience Is Related to Reduced Reinforcement Learning Signals and Elevated Dopamine Synthesis Capacity in Healthy Adults.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- The effects of cannabis use on salience attribution: a systematic review.Acta neuropsychiatrica · 2018Pooled it
- Ghrelin decreases sensitivity to negative feedback and increases prediction-error related caudate activity in humans, a randomized controlled trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Trial
- Refining mechanistic models of hallucinations for enhanced translatability.Translational psychiatry · 2025Review
- Altered processing of self-produced sensations in psychosis at cortical and spinal levels.Molecular psychiatry · 2025Article
- Biomarker discovery using machine learning in the psychosis spectrum.Biomarkers in neuropsychiatry · 2024Article
- Impaired striatal glutamate/GABA regulation in violent offenders with antisocial personality disorder and psychopathy.Molecular psychiatry · 2024Article
- Behavioral Response to Catecholamine Depletion in Individuals With Schizophrenia and Healthy Volunteers.Schizophrenia bulletin open · 2023Article
- Belief Updating in Subclinical and Clinical Delusions.Schizophrenia bulletin open · 2023Article
- Neural Circuitry of Salience and Reward Processing in Psychosis.Biological psychiatry global open science · 2023Review
- An integrated cluster-wise significance measure for fMRI analysis.Human brain mapping · 2022Article
- Relative salience signaling within a thalamo-orbitofrontal circuit governs learning rate.Current biology : CB · 2021Article
- Striatal Dopamine and Reward Prediction Error Signaling in Unmedicated Schizophrenia Patients.Schizophrenia bulletin · 2020Article
- The interplay between childhood trauma, cognitive biases, and cannabis use on the risk of psychosis in nonclinical young adults in Poland.European psychiatry : the journal of the Association of European Psychiatrists · 2020Article
- Hippocampal Hyperactivity as a Druggable Circuit-Level Origin of Aberrant Salience in Schizophrenia.Frontiers in pharmacology · 2020Review
- Chronic psychosocial stressors are associated with alterations in salience processing and corticostriatal connectivity.Schizophrenia research · 2019Article
- Reduced parietofrontal effective connectivity during a working-memory task in people with high delusional ideationJournal of psychiatry & neuroscience : JPN · 2019Article
- Motivational deficits in schizophrenia relate to abnormalities in cortical learning rate signals.Cognitive, affective & behavioral neuroscience · 2018Article
- Modeling subjective relevance in schizophrenia and its relation to aberrant salience.PLoS computational biology · 2018Article
- The link between schizophrenia and substance use disorder: A unifying hypothesis.Schizophrenia research · 2018Review
- Ventral Striatal Dysfunction and Symptom Expression in Individuals With Schizotypal Personality Traits and Early Psychosis.Schizophrenia bulletin · 2018Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The striatum is known to play a key role in reinforcement learning, specifically in the encoding of teaching signals such as reward prediction errors (RPEs). It has been proposed that aberrant salience attribution is associated with impaired coding of RPE and heightened dopamine turnover in the striatum, and might be linked to the development of psychotic symptoms. However, the relationship of aberrant salience attribution, RPE coding, and dopamine synthesis capacity has not been directly investigated. Here we assessed the association between a behavioral measure of aberrant salience attribution, the salience attribution test, to neural correlates of RPEs measured via functional magnetic resonance imaging while healthy participants (n = 58) performed an instrumental learning task. A subset of participants (n = 27) also underwent positron emission tomography with the radiotracer [(18)F]fluoro-l-DOPA to quantify striatal presynaptic dopamine synthesis capacity. Individual variability in aberrant salience measures related negatively to ventral striatal and prefrontal RPE signals and in an exploratory analysis was found to be positively associated with ventral striatal presynaptic dopamine levels. These data provide the first evidence for a specific link between the constructs of aberrant salience attribution, reduced RPE processing, and potentially increased presynaptic dopamine function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.