ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2015
Retention of sedentary obese visceral white adipose tissue phenotype with intermittent physical activity despite reduced adiposity.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Suppression of estrogen receptor beta classical genomic activity enhances systemic and adipose-specific response to chronic beta-3 adrenergic receptor (β3AR) stimulation.Frontiers in physiology · 2022Article
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- Role of ERβ in adipocyte metabolic response to wheel running following ovariectomy.The Journal of endocrinology · 2021Article
- Effects of ERβ and ERα on OVX-induced changes in adiposity and insulin resistance.The Journal of endocrinology · 2020Article
- Reactive oxygen species-dependent regulation of pyruvate dehydrogenase kinase-4 in white adipose tissue.American journal of physiology. Cell physiology · 2020Article
- Overproduction of endothelin-1 impairs glucose tolerance but does not promote visceral adipose tissue inflammation or limit metabolic adaptations to exercise.American journal of physiology. Endocrinology and metabolism · 2019Article
- High-saturated-fat diet-induced obesity causes hepatic interleukin-6 resistance via endoplasmic reticulum stress.Journal of lipid research · 2019Article
- Estrogen receptor-α signaling maintains immunometabolic function in males and is obligatory for exercise-induced amelioration of nonalcoholic fatty liver.American journal of physiology. Endocrinology and metabolism · 2019Article
- Beta 3 Adrenergic Receptor Activation Rescues Metabolic Dysfunction in Female Estrogen Receptor Alpha-Null Mice.Frontiers in physiology · 2019Article
- Links between Immunologic Memory and Metabolic Cycling.Journal of immunology (Baltimore, Md. : 1950) · 2018Review
- Removal of interscapular brown adipose tissue increases aortic stiffness despite normal systemic glucose metabolism in mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Endothelial dysfunction occurs independently of adipose tissue inflammation and insulin resistance in ovariectomized Yucatan miniature-swine.Adipocyte · 2018Article
- Anti-inflammatory effects of exercise training in adipose tissue do not require FGF21.The Journal of endocrinology · 2017Article
- Deletion of UCP1 enhances ex vivo aortic vasomotor function in female but not male mice despite similar susceptibility to metabolic dysfunction.American journal of physiology. Endocrinology and metabolism · 2017Article
- Loss of UCP1 exacerbates Western diet-induced glycemic dysregulation independent of changes in body weight in female mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- Testosterone Deficiency Induces Changes of the Transcriptomes of Visceral Adipose Tissue in Miniature Pigs Fed a High-Fat and High-Cholesterol Diet.International journal of molecular sciences · 2016Article
- Ablation of eNOS does not promote adipose tissue inflammation.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Article
- Loss of Nlrp3 Does Not Protect Mice from Western Diet-Induced Adipose Tissue Inflammation and Glucose Intolerance.PloS one · 2016Article
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
Abstract
Regular physical activity is effective in reducing visceral white adipose tissue (AT) inflammation and oxidative stress, and these changes are commonly associated with reduced adiposity. However, the impact of multiple periods of physical activity, intercalated by periods of inactivity, i.e., intermittent physical activity, on markers of AT inflammation and oxidative stress is unknown. In the present study, 5-wk-old male C57BL/6 mice were randomized into three groups (n = 10/group): sedentary, regular physical activity, and intermittent physical activity, for 24 wk. All animals were singly housed and fed a diet containing 45% kcal from fat. Regularly active mice had access to voluntary running wheels throughout the study period, whereas intermittently active mice had access to running wheels for 3-wk intervals (i.e., 3 wk on/3 wk off) throughout the study. At death, regular and intermittent physical activity was associated with similar reductions in visceral AT mass (approximately -24%, P < 0.05) relative to sedentary. However, regularly, but not intermittently, active mice exhibited decreased expression of visceral AT genes related to inflammation (e.g., monocyte chemoattractant protein 1), immune cell infiltration (e.g., CD68, CD11c, F4/80, CD11b/CD18), oxidative stress (e.g., p47 phagocyte oxidase), and endoplasmic reticulum stress (e.g., CCAAT enhancer-binding protein homologous protein; all P < 0.05). Furthermore, regular, but not intermittent, physical activity was associated with a trend toward improvement in glucose tolerance (P = 0.059). Collectively, these findings suggest that intermittent physical activity over a prolonged period of time may lead to a reduction in adiposity but with retention of a sedentary obese white AT and metabolic phenotype.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.