ArticleProceedings. Biological sciences2015
Homeobox transcription factor Six7 governs expression of green opsin genes in zebrafish.
Article in Proceedings. Biological sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 49 citations in OpenAlex.
- A standardized nomenclature for the rods and cones of the vertebrate retina.PLoS biology · 2025Article
- Article
- Differential Regulation of Opsin Gene Expression in Response to Internal and External Stimuli.Genome biology and evolution · 2024Article
- Role of short-wave-sensitive 1 (sws1) in cone development and first feeding in larval zebrafish.Fish physiology and biochemistry · 2023Article
- Molecular mechanisms controlling vertebrate retinal patterning, neurogenesis, and cell fate specification.Trends in genetics : TIG · 2023Review
- Knockout ofInternational journal of molecular sciences · 2023Article
- Article
- Retinal Cone Mosaic in sws1-Mutant Medaka (Oryzias latipes), A Teleost.Investigative ophthalmology & visual science · 2022Article
- Development of dim-light vision in the nocturnal reef fish family Holocentridae. I: Retinal gene expression.The Journal of experimental biology · 2022Article
- Eyes on CHARGE syndrome: Roles of CHD7 in ocular development.Frontiers in cell and developmental biology · 2022Review
- Ciliary photoreceptors in sea urchin larvae indicate pan-deuterostome cell type conservation.BMC biology · 2021Article
- Foxq2 determines blue cone identity in zebrafish.Science advances · 2021Article
- Partitioning of gene expression among zebrafish photoreceptor subtypes.Scientific reports · 2021Article
- Upregulation of the PPAR signaling pathway and accumulation of lipids are related to the morphological and structural transformation of the dragon-eye goldfish eye.Science China. Life sciences · 2021Article
- Article
- Endocrine regulation of multichromatic color vision.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Six6 and Six7 coordinately regulate expression of middle-wavelength opsins in zebrafish.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Whole-genome sequences of Malawi cichlids reveal multiple radiations interconnected by gene flow.Nature ecology & evolution · 2018Article
- Toxicity Evaluation and Biomarker Selection with Validated Reference Gene in Embryonic Zebrafish Exposed to Mitoxantrone.International journal of molecular sciences · 2018Article
- A novel transgenic zebrafish line for red opsin expression in outer segments of photoreceptor cells.Developmental dynamics : an official publication of the American Association of Anatomists · 2018Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Colour discrimination in vertebrates requires cone photoreceptor cells in the retina, and high-acuity colour vision is endowed by a set of four cone subtypes expressing UV-, blue-, green- and red-sensitive opsins. Previous studies identified transcription factors governing cone photoreceptor development in mice, although loss of blue and green opsin genes in the evolution of mammals make it difficult to understand how high-acuity colour vision was organized during evolution and development. Zebrafish (Danio rerio) represents a valuable vertebrate model for studying colour vision as it retains all the four ancestral vertebrate cone subtypes. Here, by RT-qPCR and in situ hybridization analysis, we found that sine oculis homeobox homolog 7 (six7), a transcription factor widely conserved in ray-finned fish, is expressed predominantly in the cone photoreceptors in zebrafish at both the larval and the adult stages. TAL effector nuclease-based six7 knock-out revealed its roles in expression of green, red and blue cone opsin genes. Most prominently, the six7 deficiency caused a loss of expression of all the green opsins at both the larval and adult stages. six7 is indispensable for the development and/or maintenance of the green cones.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.