ArticleThe Journal of comparative neurology2016
Mapping chromatic pathways in the Drosophila visual system.
Article in The Journal of comparative neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Synaptic-resolution connectomics: towards large brains and connectomic screening.Nature reviews. Neuroscience · 2026Review
- On analogies in vertebrate and insect visual systems.Nature reviews. Neuroscience · 2025Review
- Spectral preferences of mosquitos are altered by odors.The Journal of experimental biology · 2025Article
- Functional labeling of individualized postsynaptic neurons using optogenetics and trans-Tango in Drosophila (FLIPSOT).PLoS genetics · 2024Article
- Multiple axes of visual system diversity in Ithomiini, an ecologically diverse tribe of mimetic butterflies.The Journal of experimental biology · 2023Article
- Different spectral sensitivities of ON- and OFF-motion pathways enhance the detection of approaching color objects in Drosophila.Nature communications · 2023Article
- High diversity of arthropod colour vision: from genes to ecology.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Article
- Finding Needles in a Haystack with Light: Resolving the Microcircuitry of the Brain with Fluorescence Microscopy.Molecules and cells · 2022Review
- From Photons to Behaviors: Neural Implementations of Visual Behaviors inFrontiers in neuroscience · 2022Review
- Synaptic targets of photoreceptors specialized to detect color and skylight polarization ineLife · 2021Article
- Sleep deprivation results in diverse patterns of synaptic scaling across the Drosophila mushroom bodies.Current biology : CB · 2021Article
- Niwaki Instead of Random Forests: Targeted Serial Sectioning Scanning Electron Microscopy With Reimaging Capabilities for Exploring Central Nervous System Cell Biology and Pathology.Frontiers in neuroanatomy · 2021Review
- GFP-Tagged Protein Detection by Electron Microscopy Using a GBP-APEX Tool inFrontiers in cell and developmental biology · 2021Article
- Spectral response properties of higher visual neurons in Drosophila melanogaster.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2020Article
- Color vision in insects: insights from Drosophila.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2020Review
- A network approach to analyze neuronal lineage and layer innervation in the Drosophila optic lobes.PloS one · 2020Article
- Better Sleep at Night: How Light Influences Sleep inFrontiers in physiology · 2020Review
- Article
- The HisCl1 histamine receptor acts in photoreceptors to synchronize Drosophila behavioral rhythms with light-dark cycles.Nature communications · 2019Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
In Drosophila, color vision and wavelength-selective behaviors are mediated by the compound eye's narrow-spectrum photoreceptors R7 and R8 and their downstream medulla projection (Tm) neurons Tm5a, Tm5b, Tm5c, and Tm20 in the second optic neuropil or medulla. These chromatic Tm neurons project axons to a deeper optic neuropil, the lobula, which in insects has been implicated in processing and relaying color information to the central brain. The synaptic targets of the chromatic Tm neurons in the lobula are not known, however. Using a modified GFP reconstitution across synaptic partners (GRASP) method to probe connections between the chromatic Tm neurons and 28 known and novel types of lobula neurons, we identify anatomically the visual projection neurons LT11 and LC14 and the lobula intrinsic neurons Li3 and Li4 as synaptic targets of the chromatic Tm neurons. Single-cell GRASP analyses reveal that Li4 receives synaptic contacts from over 90% of all four types of chromatic Tm neurons, whereas LT11 is postsynaptic to the chromatic Tm neurons, with only modest selectivity and at a lower frequency and density. To visualize synaptic contacts at the ultrastructural level, we develop and apply a "two-tag" double-labeling method to label LT11's dendrites and the mitochondria in Tm5c's presynaptic terminals. Serial electron microscopic reconstruction confirms that LT11 receives direct contacts from Tm5c. This method would be generally applicable to map the connections of large complex neurons in Drosophila and other animals.
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