SynthesisScientific reports2015
Serum and hair zinc levels in breast cancer: a meta-analysis.
Synthesis in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 4 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Systematic Review and Meta-Analysis: Association Between Circulating and Tissue Levels of Selenium and Zinc and Breast Cancer Risk.The breast journal · 2026Pooled it
- The association between zinc and prostate cancer development: A systematic review and meta-analysis.PloS one · 2024Pooled it
- Comparative study of serum zinc concentrations in benign and malignant prostate disease: A Systematic Review and Meta-Analysis.Scientific reports · 2016Pooled it
- Zinc levels in seminal plasma and their correlation with male infertility: A systematic review and meta-analysis.Scientific reports · 2016Pooled it
- Pathophysiological significance of impaired KAT7-dependent histone H3K14 acetylation during zinc deficiency.Nature communications · 2026Article
- Serum metabolite and metal ions profiles for breast cancer screening.Scientific reports · 2024Article
- Zinc Deficiency as a General Feature of Cancer: a Review of the Literature.Biological trace element research · 2024Review
- Association of serum and hair antioxidant minerals with an oxidative stress marker in relation with characteristics of healthy adults: a cross-sectional study.Scientific reports · 2024Article
- Cellular zinc metabolism and zinc signaling: from biological functions to diseases and therapeutic targets.Signal transduction and targeted therapy · 2024Review
- Systemic Essential Metal and Metalloid Levels in Patients with Benign Breast Disease and Breast Cancer.Biological trace element research · 2022Article
- Zinc and Breast Cancer Survival: A Prospective Cohort Study of Dietary Intake and Serum Levels.Nutrients · 2022Article
- Personalized Nutrition as a Key Contributor to Improving Radiation Response in Breast Cancer.International journal of molecular sciences · 2021Review
- Serum zinc and dietary intake of zinc in relation to risk of different breast cancer subgroups and serum levels as a marker of intake: a prospective nested case-control study.Breast cancer research and treatment · 2021Article
- Are trace element concentrations suitable biomarkers for the diagnosis of cancer?Redox biology · 2021Article
- Biochemical Assessments of Seminal Plasma Zinc, Testis-Expressed Sequence 101 and Free Amino Acids and Their Correlations with Reproductive Hormones in Male Infertility.Biological trace element research · 2021Article
- Delineating colorectal cancer distribution, interaction, and risk prediction by environmental risk factors and serum trace elements.Scientific reports · 2020Article
- Recent aspects of the effects of zinc on human health.Archives of toxicology · 2020Review
- Serum Trace Elements and Their Associations with Breast Cancer Subgroups in Korean Breast Cancer Patients.Nutrients · 2018Article
- Zinc transporters and dysregulated channels in cancers.Frontiers in bioscience (Landmark edition) · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many studies have investigated the association between serum/hair zinc levels and breast cancer, but the results were inconsistent. To compare the serum and hair zinc levels in women with breast cancer and controls, we conducted a systematic literature search of PubMed, Web of Science, Cochrane Library and Embase to identify relevant studies with publication dates up through November 2014. Based on a random effects model, summary standard mean differences (SMDs) and the corresponding 95% confidence intervals (CIs) were used to compare the serum and hair zinc levels in women with breast cancer and controls. Fourteen studies that investigated serum zinc levels and seven studies that assessed hair zinc levels were included. Our study observed no difference in serum zinc levels between breast cancer cases and controls (SMD (95%CI): -0.65[-1.42, 0.13]). However, we determined that hair zinc levels were lower in women with breast cancer compared with those of controls (SMD (95%CI): -1.99[-3.46, -0.52]). In conclusion, this study was the first to provide evidence that hair zinc levels in female breast cancer patients are lower than in controls; however, there was no significant difference in serum zinc levels between female breast cancer patients and controls.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.