ArticleScientific reports2015
Regulation of microtubule dynamics by DIAPH3 influences amoeboid tumor cell mechanics and sensitivity to taxanes.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 48 citations in OpenAlex.
- Loss of DIAPH3 accelerates glioma genesis in mice.Cell death & disease · 2026Article
- DIAPH3 is a multifaceted prognostic biomarker that links immunotherapy response to tumor microenvironment in prostate cancer.Discover oncology · 2026Article
- DIAPH3 predicts survival of patients withFrontiers in oncology · 2024Article
- Role of actin-binding proteins in prostate cancer.Frontiers in cell and developmental biology · 2024Review
- The emerging role of microtubules in invasion plasticity.Frontiers in oncology · 2023Review
- DIAPH3 is a prognostic biomarker and inhibit colorectal cancer progression through maintaining EGFR degradation.Cancer medicine · 2022Article
- Gene expression profiling and in vitro functional studies reveal RAD54L as a potential therapeutic target in multiple myeloma.Genes & genomics · 2022Article
- Formins in Human Disease.Cells · 2021Review
- Article
- Identification of hub genes in colorectal cancer based on weighted gene co-expression network analysis and clinical data from The Cancer Genome Atlas.Bioscience reports · 2021Article
- Diaphanous related formin 3 knockdown suppresses cell proliferation and metastasis of osteosarcoma cells.Discover oncology · 2021Article
- DIAPH3 deficiency links microtubules to mitotic errors, defective neurogenesis, and brain dysfunction.eLife · 2021Article
- Comprehensive palmitoyl-proteomic analysis identifies distinct protein signatures for large and small cancer-derived extracellular vesicles.Journal of extracellular vesicles · 2020Article
- A cancer stem cell-like phenotype is associated with miR-10b expression in aggressive squamous cell carcinomas.Cell communication and signaling : CCS · 2020Article
- TIP5 primes prostate luminal cells for the oncogenic transformation mediated byProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Sex as a Determinant of Responses to a Coronary Artery Disease Self-Antigen Identified by Immune-Peptidomics.Frontiers in immunology · 2020Article
- Construction and validation of an eight-gene signature with great prognostic value in bladder cancer.Journal of Cancer · 2020Article
- Low-Background Acyl-Biotinyl Exchange Largely Eliminates the Coisolation of Non-Analytical chemistry · 2019Article
- Article
- Keratin 8 is a potential self-antigen in the coronary artery disease immunopeptidome: A translational approach.PloS one · 2019Article
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Authors and funding
17 authors at 3 institutions in 1 country.
Funding
Abstract
Taxanes are widely employed chemotherapies for patients with metastatic prostate and breast cancer. Here, we show that loss of Diaphanous-related formin-3 (DIAPH3), frequently associated with metastatic breast and prostate cancers, correlates with increased sensitivity to taxanes. DIAPH3 interacted with microtubules (MT), and its loss altered several parameters of MT dynamics as well as decreased polarized force generation, contractility, and response to substrate stiffness. Silencing of DIAPH3 increased the cytotoxic response to taxanes in prostate and breast cancer cell lines. Analysis of drug activity for tubulin-targeted agents in the NCI-60 cell line panel revealed a uniform positive correlation between reduced DIAPH3 expression and drug sensitivity. Low DIAPH3 expression correlated with improved relapse-free survival in breast cancer patients treated with chemotherapeutic regimens containing taxanes. Our results suggest that inhibition of MT stability arising from DIAPH3 downregulation enhances susceptibility to MT poisons, and that the DIAPH3 network potentially reports taxane sensitivity in human tumors.
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