ReviewThe Journal of comparative neurology2016
Evolution of the mammalian dentate gyrus.
Review in The Journal of comparative neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 84 citations in OpenAlex.
- Homologous cell type markers highlight subdivisions of the domestic chick hippocampal formation.Scientific reports · 2026Article
- SATB1 Exhibits a Protective Role in HAmylin-Oligomer-Induced Neuronal Damage and Cognition Decline.CNS neuroscience & therapeutics · 2026Article
- Orchestrated molecular changes of proliferative, migratory-fibrillar, synaptic, and postmigratory compartments align with precocious cortex-type specification in the early human pallium.Journal of anatomy · 2026Article
- In Vivo Quantification of White Matter Pathways in the Human Hippocampus.Human brain mapping · 2025Article
- Mossy fiber expression of αSMA in human hippocampus and its relevance to brain evolution and neuronal development.Scientific reports · 2025Article
- Expression of GCaMP6s in the dentate gyrus induces tonic-clonic seizures.Scientific reports · 2024Article
- Sex-Specific and Traumatic Brain Injury Effects on Dopamine Receptor Expression in the Hippocampus.International journal of molecular sciences · 2023Article
- Lmx1a is a master regulator of the cortical hem.eLife · 2023Article
- Clade-specific forebrain cytoarchitectures of the extinct Tasmanian tiger.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Molecular biology of serotonergic systems in avian brains.Frontiers in molecular neuroscience · 2023Review
- Chick Hippocampal Formation Displays Subdivision- and Layer-Selective Expression Patterns of Serotonin Receptor Subfamily Genes.Frontiers in physiology · 2022Article
- What Is the Relationship Between Hippocampal Neurogenesis Across Different Stages of the Lifespan?Frontiers in neuroscience · 2022Article
- Orexin neuropeptides modulate the hippocampal-dependent memory through basolateral amygdala interconnections.Cerebral circulation - cognition and behavior · 2022Review
- Regional Patterning of Adult Neurogenesis in the Homing Pigeon's Brain.Frontiers in psychology · 2022Article
- What Is Adult Hippocampal Neurogenesis Good for?Frontiers in neuroscience · 2022Article
- Spatial cognition and the avian hippocampus: Research in domestic chicks.Frontiers in psychology · 2022Review
- Adult Neurogenesis: A Story Ranging from Controversial New Neurogenic Areas and Human Adult Neurogenesis to Molecular Regulation.International journal of molecular sciences · 2021Review
- Sevoflurane Postconditioning Ameliorates Neuronal Migration Disorder Through Reelin/Dab1 and Improves Long-term Cognition in Neonatal Rats After Hypoxic-Ischemic Injury.Neurotoxicity research · 2021Article
- Spatial and temporal changes in the PGE2 EP2 receptor in mice hippocampi during postnatal development and its relationship with cyclooxygenase-2.Iranian journal of basic medical sciences · 2021Article
- The Proliferation of Dentate Gyrus Progenitors in the Ferret Hippocampus by Neonatal Exposure to Valproic Acid.Frontiers in neuroscience · 2021Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The dentate gyrus (DG), a part of the hippocampal formation, has important functions in learning, memory, and adult neurogenesis. Compared with homologous areas in sauropsids (birds and reptiles), the mammalian DG is larger and exhibits qualitatively different phenotypes: 1) folded (C- or V-shaped) granule neuron layer, concave toward the hilus and delimited by a hippocampal fissure; 2) nonperiventricular adult neurogenesis; and 3) prolonged ontogeny, involving extensive abventricular (basal) migration and proliferation of neural stem and progenitor cells (NSPCs). Although gaps remain, available data indicate that these DG traits are present in all orders of mammals, including monotremes and marsupials. The exception is Cetacea (whales, dolphins, and porpoises), in which DG size, convolution, and adult neurogenesis have undergone evolutionary regression. Parsimony suggests that increased growth and convolution of the DG arose in stem mammals concurrently with nonperiventricular adult hippocampal neurogenesis and basal migration of NSPCs during development. These traits could all result from an evolutionary change that enhanced radial migration of NSPCs out of the periventricular zones, possibly by epithelial-mesenchymal transition, to colonize and maintain nonperiventricular proliferative niches. In turn, increased NSPC migration and clonal expansion might be a consequence of growth in the cortical hem (medial patterning center), which produces morphogens such as Wnt3a, generates Cajal-Retzius neurons, and is regulated by Lhx2. Finally, correlations between DG convolution and neocortical gyrification (or capacity for gyrification) suggest that enhanced abventricular migration and proliferation of NSPCs played a transformative role in growth and folding of neocortex as well as archicortex.
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Registered trials
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