ArticleJournal of clinical microbiology2015
Genomic Epidemiology of a Protracted Hospital Outbreak Caused by a Toxin A-Negative Clostridium difficile Sublineage PCR Ribotype 017 Strain in London, England.
Article in Journal of clinical microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed.
- Mechanisms ofFrontiers in cellular and infection microbiology · 2025Review
- Comparative Genomics of Clostridioides difficile.Advances in experimental medicine and biology · 2024Article
- Ribotypes and New Virulent Strains Across Europe.Advances in experimental medicine and biology · 2024Review
- Host Immunity and Immunization Strategies for Clostridioides difficile Infection.Clinical microbiology reviews · 2023Review
- Recombinant Fusion Protein Vaccine Containing Clostridioides difficile FliC and FliD Protects Mice against C. difficile Infection.Infection and immunity · 2023Article
- The Environment, Farm Animals and Foods as Sources ofFoods (Basel, Switzerland) · 2023Article
- Low Viral Diversity Limits the Effectiveness of Sequence-Based Transmission Inference for SARS-CoV-2.mSphere · 2023Article
- Systems biology approach to functionally assess theProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Global evolutionary dynamics and resistome analysis ofMicrobial genomics · 2022Article
- Genetic Relatedness of 5-Year Isolates ofAntibiotics (Basel, Switzerland) · 2021Article
- Murine Intrarectal Instillation of Purified RecombinantInfection and immunity · 2021Article
- Article
- Clostridium difficile clade 3 (RT023) have a modified cell surface and contain a large transposable island with novel cargo.Scientific reports · 2019Article
- Enterotoxic Clostridia:Microbiology spectrum · 2019Review
- Review
- National Surveillance for Clostridioides difficile Infection, Sweden, 2009-2016.Emerging infectious diseases · 2018Article
- Identification and Characterization of Clostridium difficile Sequence Type 37 Genotype by Matrix-Assisted Laser Desorption IonizationJournal of clinical microbiology · 2018Article
- Epidemiological aspects of healthcare-associated infections and microbial genomics.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2018Review
- Genomic survey of Clostridium difficile reservoirs in the East of England implicates environmental contamination of wastewater treatment plants by clinical lineages.Microbial genomics · 2018Article
- Genomic Study of aFrontiers in microbiology · 2018Article
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Authors and funding
6 authors.
Funding
Abstract
Clostridium difficile remains the leading cause of nosocomial diarrhea worldwide, which is largely considered to be due to the production of two potent toxins: TcdA and TcdB. However, PCR ribotype (RT) 017, one of five clonal lineages of human virulent C. difficile, lacks TcdA expression but causes widespread disease. Whole-genome sequencing was applied to 35 isolates from hospitalized patients with C. difficile infection (CDI) and two environmental ward isolates in London, England. The phylogenetic analysis of single nucleotide polymorphisms (SNPs) revealed a clonal cluster of temporally variable isolates from a single hospital ward at University Hospital Lewisham (UHL) that were distinct from other London hospital isolates. De novo assembled genomes revealed a 49-kbp putative conjugative transposon exclusive to this hospital clonal cluster which would not be revealed by current typing methodologies. This study identified three sublineages of C. difficile RT017 that are circulating in London. Similar to the notorious RT027 lineage, which has caused global outbreaks of CDI since 2001, the lineage of toxin-defective RT017 strains appears to be continually evolving. By utilization of WGS technologies to identify SNPs and the evolution of clonal strains, the transmission of outbreaks caused by near-identical isolates can be retraced and identified.
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