ArticleLearning & memory (Cold Spring Harbor, N.Y.)2015
Prediction error and trace dominance determine the fate of fear memories after post-training manipulations.
Article in Learning & memory (Cold Spring Harbor, N.Y.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Modulation of naturalistic maladaptive memories using behavioural and pharmacological reconsolidation-interfering strategies: a systematic review and meta-analysis of clinical and 'sub-clinical' studies.Psychopharmacology · 2018Pooled it
- Pooled it
- Neurotransmitters in memory destabilization: An integrative perspective framed by prediction error and novelty.Cognitive, affective & behavioral neuroscience · 2026Review
- Heat exposure following encoding can interfere with subsequent recognition memory.Scientific reports · 2023Article
- Appraising reconsolidation theory and its empirical validation.Psychonomic bulletin & review · 2023Review
- Over the Edge: Extending the duration of a reconsolidation intervention for spider fear.Translational psychiatry · 2022Article
- Memory destabilization during reconsolidation: a consequence of homeostatic plasticity?Learning & memory (Cold Spring Harbor, N.Y.) · 2021Article
- Using Extinction-Renewal to Circumvent the Memory Strength Boundary Condition in Fear Memory Reconsolidation.Brain sciences · 2021Article
- Apparent reconsolidation interference without generalized amnesia.Progress in neuro-psychopharmacology & biological psychiatry · 2021Article
- Placebo and Non-specific Effects in Reconsolidation-Based Treatment for Arachnophobia.Frontiers in psychiatry · 2021Article
- Generalization and recovery of post-retrieval amnesia.Journal of experimental psychology. General · 2020Article
- Destabilizing Different Strengths of Fear Memories Requires Different Degrees of Prediction Error During Retrieval.Frontiers in behavioral neuroscience · 2020Article
- Retrieval-Dependent Mechanisms Affecting Emotional Memory Persistence: Reconsolidation, Extinction, and the Space in Between.Frontiers in behavioral neuroscience · 2020Review
- Limited replicability of drug-induced amnesia after contextual fear memory retrieval in rats.Neurobiology of learning and memory · 2019Article
- Post-weaning housing conditions influence freezing during contextual fear conditioning in adult rats.Behavioural brain research · 2019Article
- EZH2 Methyltransferase Activity Controls Pten Expression and mTOR Signaling during Fear Memory Reconsolidation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- A Novel Retrieval-Dependent Memory Process Revealed by the Arrest of ERK1/2 Activation in the Basolateral Amygdala.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Breaking boundaries: optimizing reconsolidation-based interventions for strong and old memories.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- On the transition from reconsolidation to extinction of contextual fear memories.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- A comparison of behavioral and pharmacological interventions to attenuate reactivated fear memories.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Different mnemonic outcomes have been observed when associative memories are reactivated by CS exposure and followed by amnestics. These outcomes include mere retrieval, destabilization-reconsolidation, a transitional period (which is insensitive to amnestics), and extinction learning. However, little is known about the interaction between initial learning conditions and these outcomes during a reinforced or nonreinforced reactivation. Here we systematically combined temporally specific memories with different reactivation parameters to observe whether these four outcomes are determined by the conditions established during training. First, we validated two training regimens with different temporal expectations about US arrival. Then, using Midazolam (MDZ) as an amnestic agent, fear memories in both learning conditions were submitted to retraining either under identical or different parameters to the original training. Destabilization (i.e., susceptibly to MDZ) occurred when reactivation was reinforced, provided the occurrence of a temporal prediction error about US arrival. In subsequent experiments, both treatments were systematically reactivated by nonreinforced context exposure of different lengths, which allowed to explore the interaction between training and reactivation lengths. These results suggest that temporal prediction error and trace dominance determine the extent to which reactivation produces the different outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.