Trial reportCirculation. Heart failure2015
Acute Dietary Nitrate Intake Improves Muscle Contractile Function in Patients With Heart Failure: A Double-Blind, Placebo-Controlled, Randomized Trial.
Trial report in Circulation. Heart failure, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 77 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Dietary Nitrate for Heart Failure
Dietary Nitrate and Muscle Power With Aging
Dose-response Effect of Dietary Nitrate on Muscle Function in Older Individuals
Who cites it
77 citing papers in PubMed, 8 syntheses or guidelines pooled it, 133 citations in OpenAlex.
- Dietary Nitrate Supplementation and Exercise Performance: An Umbrella Review of 20 Published Systematic Reviews with Meta-analyses.Sports medicine (Auckland, N.Z.) · 2025Pooled it
- Plasma nitrate, dietary nitrate, blood pressure, and vascular health biomarkers: a GRADE-Assessed systematic review and dose-response meta-analysis of randomized controlled trials.Nutrition journal · 2025Pooled it
- Ergogenic Effect of Nitrate Supplementation in Clinical Populations: A Systematic Review and Meta-Analysis.Nutrients · 2024Pooled it
- Limited Effects of Inorganic Nitrate Supplementation on Exercise Training Responses: A Systematic Review and Meta-analysis.Sports medicine - open · 2023Pooled it
- Effects of Dietary Nitrate Supplementation on Back Squat and Bench Press Performance: A Systematic Review and Meta-Analysis.Nutrients · 2023Pooled it
- The Effects of Dietary Nitrate Supplementation on Explosive Exercise Performance: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Effect of dietary nitrate on human muscle power: a systematic review and individual participant data meta-analysis.Journal of the International Society of Sports Nutrition · 2021Pooled it
- The Effect of Dietary Nitrate Supplementation on Isokinetic Torque in Adults: A Systematic Review and Meta-Analysis.Nutrients · 2020Pooled it
- Opposing Effects of Dietary Nitrate on Muscle Contractile Function in Fast and Slow Human Muscles.Medicine and science in sports and exercise · 2026Trial
- Dietary nitrate and muscle contractile function in women: effect of menstrual cycle phase.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Trial
- Acute effects of beetroot extract and resveratrol ingestion on cardiovascular and cardiac autonomic modulation recovery after moderate-intensity aerobic exercise in individuals with coronary artery disease: a triple-blinded, randomized, placebo-controlled trial.European journal of nutrition · 2025Trial
- Pilot randomized trial of the effect of antibacterial mouthwash on muscle contractile function in healthy young adults.PloS one · 2025Trial
- The influence of sex on the effects of inorganic nitrate supplementation on muscular power and endurance.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Trial
- Dose-Response Effect of Dietary Nitrate on Muscle Contractility and Blood Pressure in Older Subjects: A Pilot Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Trial
- Leg heat therapy improves perceived physical function but does not enhance walking capacity or vascular function in patients with peripheral artery disease.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Trial
- Acute Effects of Beetroot Juice Supplements on Resistance Training: A Randomized Double-Blind Crossover.Nutrients · 2020Trial
- A Single Dose of Dietary Nitrate Increases Maximal Knee Extensor Angular Velocity and Power in Healthy Older Men and Women.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Trial
- A Single Dose of Beetroot Juice Does Not Change Blood Pressure Response Mediated by Acute Aerobic Exercise in Hypertensive Postmenopausal Women.Nutrients · 2019Trial
- Trial
- Dietary nitrate does not modify blood pressure and cardiac output at rest and during exercise in older adults: a randomised cross-over study.International journal of food sciences and nutrition · 2018Trial
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
backgroundSkeletal muscle strength, velocity, and power are markedly reduced in patients with heart failure, which contributes to their impaired exercise capacity and lower quality of life. This muscle dysfunction may be partially because of decreased nitric oxide (NO) bioavailability. We therefore sought to determine whether ingestion of inorganic nitrate (NO3 (-)) would increase NO production and improve muscle function in patients with heart failure because of systolic dysfunction. METHODS AND
resultsUsing a double-blind, placebo-controlled, randomized crossover design, we determined the effects of dietary NO3 (-) in 9 patients with heart failure. After fasting overnight, subjects drank beetroot juice containing or devoid of 11.2 mmol of NO3 (-). Two hours later, muscle function was assessed using isokinetic dynamometry. Dietary NO3 (-) increased (P<0.05-0.001) breath NO by 35% to 50%. This was accompanied by 9% (P=0.07) and 11% (P<0.05) increases in peak knee extensor power at the 2 highest movement velocities tested (ie, 4.71 and 6.28 rad/s). Maximal power (calculated by fitting peak power data with a parabola) was therefore greater (ie, 4.74±0.41 versus 4.20±0.33 W/kg; P<0.05) after dietary NO3 (-) intake. Calculated maximal velocity of knee extension was also higher after NO3 (-) ingestion (ie, 12.48±0.95 versus 11.11±0.53 rad/s; P<0.05). Blood pressure was unchanged, and no adverse clinical events occurred.
conclusionsIn this pilot study, acute dietary NO3 (-) intake was well tolerated and enhanced NO bioavailability and muscle power in patients with systolic heart failure. Larger-scale studies should be conducted to determine whether the latter translates into an improved quality of life in this population. CLINICAL
trial registrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT01682356.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.