Evidence map›Paper›PMID 26179144›Full record

ArticleJournal of biochemical and molecular toxicology2015

Isoform-Specific Regulation of Mouse Carboxylesterase Expression and Activity by Prototypical Transcriptional Activators.

Angela A Baker, Grace L Guo, Lauren M Aleksunes, Jason R Richardson

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biochemical and molecular toxicology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Angela A BakerEnvironmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, NJ, 08854, USA.
Grace L GuoEnvironmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, NJ, 08854, USA.
Lauren M AleksunesEnvironmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, NJ, 08854, USA.
Jason R RichardsonEnvironmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, NJ, 08854, USA. Jricha3@eohsi.rutgers.edu.
Rutgers, The State University of New Jersey · USEnvironmental and Occupational Health Sciences Institute · USJohnson University · US

Funding

Translational Research Support CoreP30ES005022 · NIEHS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI PANOS G. GEORGOPOULOS · 1988 to 2026
$47.4M
TRAINING IN EVIRONMENTAL TOXICOLOGYT32ES007148 · NIEHS · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI Lauren M Aleksunes · 1987 to 2026
$11.4M
Developing Drugs to Mitigate Parathion IntoxicationU01NS079249 · NINDS · RBHS-SCHOOL OF PUBLIC HEALTH · PI LASKIN, JEFFREY D, RICHARDSON, JASON R · 2013 to 2017
$4.0M
Mechanisms of Pesticide-Induced Neurobehavioral Deficits: Relevance to ADHDR01ES015991 · NIEHS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI RICHARDSON, JASON R · 2007 to 2011
$3.2M
Disposition of Environmental Chemicals During PregnancyR01ES020522 · NIEHS · RUTGERS, THE STATE UNIV OF N.J. · PI ALEKSUNES, LAUREN M · 2011 to 2015
$2.1M
Gut bile acids, Fxr, & Fgf15 in total parenteral nutrition-associated cholestasisR01GM104037 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI GUO, GRACE L · 2013 to 2016
$1.1M
NIEHS NIH HHS P30 ES005022NIEHS NIH HHS P30ES005022NIEHS NIH HHS R01 ES015991NIEHS NIH HHS R01ES015991NIEHS NIH HHS R01 ES020522NIEHS NIH HHS R01ES020522NIEHS NIH HHS T32 ES007148NIEHS NIH HHS T32ES007148NIGMS NIH HHS R01 GM104037NIGMS NIH HHS R01GM104037NINDS NIH HHS U01 NS079249NINDS NIH HHS U01NS079249
6 · The paper itself

Abstract

Nuclear receptors and transcription factors regulate the mRNA expression of many drug metabolizing enzymes, including the carboxylesterases (Ces). However, there are few data regarding whether these changes in mRNA expression result in alteration of protein levels or activity. In the present study, we sought to determine the isoform-specific regulation of hepatic Ces mRNA expression and activity following the administration of pharmacological activators of the constitutive androstane receptor (CAR), pregnane X receptor (PXR), and nuclear factor E2-related protein (Nrf2) to mice. The CAR activator 1,4-bis-[2-(3,5-dichloropyridyloxy)] benzene (TCPOBOP) and PXR ligand pregnenolone-16a-carbonitrile (PCN) increased Ces mRNA expression of various Ces2 isoforms, whereas the Nrf2 activator butylated hydroxyanisole primarily reduced Ces3a mRNA expression and induced Ces1g mRNA. TCPOBOP and PCN increased Ces2 hydrolytic activity in an isoform-specific manner. Taken together, these data demonstrate that activation of CAR, PXR, and Nrf2 regulates not only Ces mRNA expression, but also isoform-specific activity.

Indexed as

AnimalsCarboxylesteraseGene Expression Regulation, EnzymologicIsoenzymesMaleMiceMice, Inbred C57BLPregnenolone CarbonitrilePyridinesRNA, MessengerTrans-Activators1,4-bis(2-(3,5-dichloropyridyloxy))benzeneCarboxylesteraseIsoenzymesPregnenolone CarbonitrilePyridinesRNA, MessengerTrans-ActivatorsCarboxylesteraseConstitutive Androstane ReceptorNrf2Nuclear ReceptorPregnane X Receptor

Identifiers

PMID26179144
PMCPMC4714961
OpenAlexW2135344053

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.