ArticleBMC complementary and alternative medicine2015
Effects of kolaviron on hepatic oxidative stress in streptozotocin induced diabetes.
Article in BMC complementary and alternative medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 46 citations in OpenAlex.
- Therapeutic role of kaempferol and myricetin in streptozotocin-induced diabetes synergistically via modulation in pancreatic amylase, glycogen storage and insulin secretion.Molecular and cellular biochemistry · 2023Article
- Therapeutic Efficacy of Natural Product 'C-Phycocyanin' in Alleviating Streptozotocin-Induced Diabetes via the Inhibition of Glycation Reaction in Rats.International journal of molecular sciences · 2022Article
- Antioxidant Potential of Non-Extractable Fractions of Dried Persimmon (Antioxidants (Basel, Switzerland) · 2022Article
- Antioxidative, Anti-Inflammatory, Anti-Obesogenic, and Antidiabetic Properties of Tea Polyphenols-The Positive Impact of Regular Tea Consumption as an Element of Prophylaxis and Pharmacotherapy Support in Endometrial Cancer.International journal of molecular sciences · 2022Review
- Biology, chemistry, and pharmacological activity ofJournal of medicinally active plants · 2022Article
- Effect of kolaviron on islet dynamics in diabetic rats.Saudi journal of biological sciences · 2022Article
- Functional relevance of Gedunin as a bona fide ligand of NADPH oxidase 5 and ROS scavenger: AnBiochemistry and biophysics reports · 2021Article
- Dietary effects ofVeterinary world · 2021Article
- Quercetin Loaded Monolaurate Sugar Esters-Based Niosomes: Sustained Release and Mutual Antioxidant-Hepatoprotective Interplay.Pharmaceutics · 2020Article
- Mid-dose losartan mitigates diabetes-induced hepatic damage by regulating iNOS, eNOS, VEGF, and NF-κB expressionsTurkish journal of medical sciences · 2019Article
- The role of pollutants in type 2 diabetes mellitus (T2DM) and their prospective impact on phytomedicinal treatment strategies.Environmental monitoring and assessment · 2018Article
- Medicinal plants with anti-inflammatory activities from selected countries and regions of Africa.Journal of inflammation research · 2018Review
- Multidirectional inhibition of cortico-hippocampal neurodegeneration by kolaviron treatment in rats.Metabolic brain disease · 2017Article
- Antidiabetic effects of Brucea javanica seeds in type 2 diabetic rats.BMC complementary and alternative medicine · 2017Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundAlteration in antioxidant defence and increase in oxidative stress that results in tissue injury is characteristic of diabetes. We evaluated the protective effects of kolaviron (a flavonoid complex extracted from the seeds of Garcinia kola) on hepatic antioxidants, lipid peroxidation and apoptosis in diabetic rats.
methodsTo induce diabetes, rats were injected with streptozotocin intraperitoneally at a single dose of 50 mg/kg. Kolaviron (100 mg/kg) was administered orally for 6 weeks (5 times weekly). Activities of liver antioxidant enzymes was analysed with Multiskan Spectrum plate reader. High performance liquid chromatography (HPLC) was used in the analysis of MDA (malondialdehyde), a product of lipid peroxidation. Apoptosis was assessed by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay.
resultDiabetic rats exhibited a significant increase in the peroxidation of hepatic lipids as observed from the elevated level of malondialdehyde (MDA). In addition, Oxygen Radical Absorbance Capacity (ORAC), level of reduced glutathione (GSH), ratio of reduced to oxidized glutathione (GSH: GSSG) and catalase (CAT) activity were decreased in the liver of diabetic rats. The activities of GPX (glutathione peroxidase) and SOD (superoxide dismutase) were unaltered in diabetic rats. TUNEL assay revealed increased apoptotic cell death in the liver. Kolaviron attenuated lipid peroxidation and apoptosis, increased CAT activity, GSH levels and GSH: GSSG ratio. The ORAC of kolaviron-treated diabetic liver was restored to near-normal values.
conclusionKolaviron protects the liver against oxidative and apoptotic damage induced by hyperglycemia.
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