ArticleScientific reports2015
Binocular Goggle Augmented Imaging and Navigation System provides real-time fluorescence image guidance for tumor resection and sentinel lymph node mapping.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- Near-Infrared Fluorescence Probes for Fluorescence-Guided Surgery: Current Clinical Probes and Emerging Candidates.Molecules (Basel, Switzerland) · 2026Review
- Bridging preclinical and clinical fluorescence-guided surgery with advanced cancer vision goggles.Npj imaging · 2026Article
- Advancements in real-time oncology diagnosis: harnessing AI and image fusion techniques.Frontiers in oncology · 2025Review
- Frugal engineering-inspired wearable augmented reality goggle system enables fluorescence-guided cancer surgery.Scientific reports · 2024Article
- Fluorescent Probes for Imaging in Humans: Where Are We Now?ACS nano · 2023Review
- Mesoscopic fluorescence lifetime imaging: Fundamental principles, clinical applications and future directions.Journal of biophotonics · 2021Review
- Design and Testing of Augmented Reality-Based Fluorescence Imaging Goggle for Intraoperative Imaging-Guided Surgery.Diagnostics (Basel, Switzerland) · 2021Article
- Detecting the Near Infrared Autofluorescence of the Human Parathyroid: Hype or Opportunity?Annals of surgery · 2020Review
- Repurposing Molecular Imaging and Sensing for Cancer Image-Guided Surgery.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2020Review
- Real-time diagnosis and visualization of tumor margins in excised breast specimens using fluorescence lifetime imaging and machine learning.Biomedical optics express · 2020Article
- Intracranial glioma xenograft model rapidly reestablishes blood-brain barrier integrity for longitudinal imaging of tumor progression using fluorescence molecular tomography and contrast agents.Journal of biomedical optics · 2020Article
- NaNature communications · 2019Article
- Fluorescence Guidance in Surgical Oncology: Challenges, Opportunities, and Translation.Molecular imaging and biology · 2019Review
- Emerging Intraoperative Imaging Modalities to Improve Surgical Precision.Molecular imaging and biology · 2018Review
- Perspective review of what is needed for molecular-specific fluorescence-guided surgery.Journal of biomedical optics · 2018Review
- Real-time cancer detection with an integrated lensless fluorescence contact imager.Biomedical optics express · 2018Article
- Development of a modular fluorescence overlay tissue imaging system for wide-field intraoperative surgical guidance.Journal of medical imaging (Bellingham, Wash.) · 2018Article
- Targeted Optical Imaging Agents in Cancer: Focus on Clinical Applications.Contrast media & molecular imaging · 2018Review
- Bio-inspired imager improves sensitivity in near-infrared fluorescence image-guided surgery.Optica · 2018Article
- Optical See-Through Cancer Vision Goggles Enable Direct Patient Visualization and Real-Time Fluorescence-Guided Oncologic Surgery.Annals of surgical oncology · 2017Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
The inability to identify microscopic tumors and assess surgical margins in real-time during oncologic surgery leads to incomplete tumor removal, increases the chances of tumor recurrence, and necessitates costly repeat surgery. To overcome these challenges, we have developed a wearable goggle augmented imaging and navigation system (GAINS) that can provide accurate intraoperative visualization of tumors and sentinel lymph nodes in real-time without disrupting normal surgical workflow. GAINS projects both near-infrared fluorescence from tumors and the natural color images of tissue onto a head-mounted display without latency. Aided by tumor-targeted contrast agents, the system detected tumors in subcutaneous and metastatic mouse models with high accuracy (sensitivity = 100%, specificity = 98% ± 5% standard deviation). Human pilot studies in breast cancer and melanoma patients using a near-infrared dye show that the GAINS detected sentinel lymph nodes with 100% sensitivity. Clinical use of the GAINS to guide tumor resection and sentinel lymph node mapping promises to improve surgical outcomes, reduce rates of repeat surgery, and improve the accuracy of cancer staging.
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Registered trials
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