ArticleGenetics2015
Evolution of Mating Systems in Basidiomycetes and the Genetic Architecture Underlying Mating-Type Determination in the Yeast Leucosporidium scottii.
Article in Genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 37 citations in OpenAlex.
- Relief of bHD1 autoinhibition and modular coupling support MAT-A pathway activation in Flammulina filiformis.Applied microbiology and biotechnology · 2026Article
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- Dissecting the homeodomainmBio · 2026Article
- Dissecting the homeodomainbioRxiv : the preprint server for biology · 2025Article
- The complex evolution and genomic dynamics of mating-type loci in Cryptococcus and Kwoniella.PLoS biology · 2025Article
- Tracing the evolution and genomic dynamics of mating-type loci inbioRxiv : the preprint server for biology · 2025Article
- Genome biology and evolution of mating-type loci in four cereal rust fungi.PLoS genetics · 2024Article
- Article
- Evolutionary Morphogenesis of Sexual Fruiting Bodies in Basidiomycota: Toward a New Evo-Devo Synthesis.Microbiology and molecular biology reviews : MMBR · 2022Review
- Large-scale fungal strain sequencing unravels the molecular diversity in mating loci maintained by long-term balancing selection.PLoS genetics · 2022Article
- Mushrooms as Potential Sources of Active Metabolites and Medicines.Frontiers in microbiology · 2022Review
- Genetic structure and evolutionary diversity of mating-type (MAT) loci in Hypsizygus marmoreus.IMA fungus · 2021Article
- Multiple Pathways to Homothallism in Closely Related Yeast Lineages in the Basidiomycota.mBio · 2021Article
- A Chromosome-Scale Assembly of the Wheat Leaf Rust PathogenFrontiers in microbiology · 2021Article
- Identification, characterization and expression ofMycoscience · 2021Article
- A Single Transcription Factor (PDD1) Determines Development and Yield of Winter Mushroom (Applied and environmental microbiology · 2019Article
- Convergent evolution of linked mating-type loci in basidiomycete fungi.PLoS genetics · 2019Article
- Article
- A second HD mating type sublocus ofPeerJ · 2019Article
- Evolutionary strata on young mating-type chromosomes despite the lack of sexual antagonism.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In most fungi, sexual reproduction is bipolar; that is, two alternate sets of genes at a single mating-type (MAT) locus determine two mating types. However, in the Basidiomycota, a unique (tetrapolar) reproductive system emerged in which sexual identity is governed by two unlinked MAT loci, each of which controls independent mechanisms of self/nonself recognition. Tetrapolar-to-bipolar transitions have occurred on multiple occasions in the Basidiomycota, resulting, for example, from linkage of the two MAT loci into a single inheritable unit. Nevertheless, owing to the scarcity of molecular data regarding tetrapolar systems in the earliest-branching lineage of the Basidiomycota (subphylum Pucciniomycotina), it is presently unclear if the last common ancestor was tetrapolar or bipolar. Here, we address this question, by investigating the mating system of the Pucciniomycotina yeast Leucosporidium scottii. Using whole-genome sequencing and chromoblot analysis, we discovered that sexual reproduction is governed by two physically unlinked gene clusters: a multiallelic homeodomain (HD) locus and a pheromone/receptor (P/R) locus that is biallelic, thereby dismissing the existence of a third P/R allele as proposed earlier. Allele distribution of both MAT genes in natural populations showed that the two loci were in strong linkage disequilibrium, but independent assortment of MAT alleles was observed in the meiotic progeny of a test cross. The sexual cycle produces fertile progeny with similar proportions of the four mating types, but approximately 2/3 of the progeny was found to be nonhaploid. Our study adds to others in reinforcing tetrapolarity as the ancestral state of all basidiomycetes.
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