Evidence map›Paper›PMID 26178205›Full record

ArticleFamilial cancer2015

Risk reducing salpingectomy and delayed oophorectomy in high risk women: views of cancer geneticists, genetic counsellors and gynaecological oncologists in the UK.

Dhivya Chandrasekaran, Usha Menon, Gareth Evans, Robin Crawford, Ertan Saridogan, Chris Jacobs, Marc Tischkowitz, Elly Brockbank, Jatinder Kalsi, Davor Jurkovic and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Familial cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
5.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Observational
  4. Article
  5. A patient decision aid for risk-reducing surgery in premenopausal BRCA1/2 mutation carriers: Development process and pilot testing.Health expectations : an international journal of public participation in health care and health policy · 2018
    Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 1 country.

Dhivya ChandrasekaranDepartment of Obstetrics and Gynaecology, Northampton General Hospital, Northampton, UK.
Usha MenonDepartment of Women's Cancer, EGA Institute for Women's Health, Gynaecological Cancer Research Centre, University College London, First Floor, Maple House, 149 Tottenham Court Road, London, W1T 7DN, UK.
Gareth EvansDepartment of Genetic Medicine, St Mary's Hospital, Manchester, UK.
Robin CrawfordDepartment of Gynaecological Oncology, Addenbrookes Hospital, Cambridge, UK.
Ertan SaridoganDepartment of Gynaecology, University College London Hospital, London, UK.
Chris JacobsDepartment of Clinical Genetics, Guys Hospital, London, UK.
Marc TischkowitzDepartment of Medical Genetics, University of Cambridge, Addenbrookes Hospital, Cambridge, UK.
Elly BrockbankCentre for Experimental Cancer Medicine, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London, UK.
Jatinder KalsiDepartment of Gynaecological Oncology, Bartshealth NHS Trust, Royal London Hospital, 10th Floor, South Block, Whitechapel Road, London, E1 1BB, UK.
Davor JurkovicDepartment of Gynaecology, University College London Hospital, London, UK.
Ranjit ManchandaDepartment of Women's Cancer, EGA Institute for Women's Health, Gynaecological Cancer Research Centre, University College London, First Floor, Maple House, 149 Tottenham Court Road, London, W1T 7DN, UK. r.manchanda@ucl.ac.uk.
Addenbrooke's Hospital · GBQueen Mary University of London · GBUniversity College London · GBGuy's Hospital · GBNorthampton General Hospital · GBRoyal London Hospital · GBSt Mary's Hospital · GBUniversity College Hospital · GB

Funding

Cancer Research UK 12677
6 · The paper itself

Abstract

Risk-reducing-salpingectomy and Delayed-Oophorectomy (RRSDO) is being proposed as a two-staged approach in place of RRSO to reduce the risks associated with premature menopause in high-risk women. We report on the acceptability/attitude of UK health professionals towards RRSDO. An anonymised web-based survey was sent to UK Cancer Genetics Group (CGG) and British Gynaecological Cancer Society (BGCS) members to assess attitudes towards RRSDO. Baseline characteristics were described using descriptive statistics. A Chi square test was used to compare categorical, Kendal-tau-b test for ordinal and Mann-Whitney test for continuous variables between two groups. 173/708 (24.4%) of invitees responded. 71% respondents (CGG = 57%/BGCS = 83%, p = 0.005) agreed with the tubal hypothesis for OC, 55% (CGG = 42%/BGCS = 66%, p = 0.003) had heard of RRSDO and 48% (CGG = 46%/BGCS = 50%) felt evidence was not currently strong enough for introduction into clinical practice. However, 60% respondents' (CGG = 48%/BGCS = 71%, p = 0.009) favoured offering RRSDO to high-risk women declining RRSO, 77% only supported RRSDO within a clinical trial (CGG = 78%/BGCS = 76%) and 81% (CGG = 76%/BGCS = 86%) advocated a UK-wide registry. Vasomotor symptoms (72%), impact on sexual function (63%), osteoporosis (59%), hormonal-therapy (55%) and subfertility (48%) related to premature menopause influenced their choice of RRSDO. Potential barriers to offering the two-stage procedure included lack of data on precise level of benefit (83%), increased surgical morbidity (79%), loss of breast cancer risk reduction associated with oophorectomy (68%), need for long-term follow-up (61%) and a proportion not undergoing DO (66%). There were variations in perception between BGCS/CGG members which are probably attributable to differences in clinical focus/expertise between these two groups. Despite concerns, there is reasonable support amongst UK clinicians to offering RRSDO to premenopausal high-risk women wishing to avoid RRSO, within a prospective clinical trial.

Indexed as

Attitude of Health PersonnelGenetic CounselingRisk Reduction BehaviorBRCA1 ProteinBRCA2 ProteinFemaleGenetic Predisposition to DiseaseGerm-Line MutationHumansOvarian NeoplasmsOvariectomyPractice Patterns, Physicians'PrognosisSalpingectomyBRCA1 ProteinBRCA1 protein, humanBRCA2 ProteinBRCA2 protein, humanBRCADelayed oophorectomyHigh-riskOvarian cancerRisk reducing salpingectomyRRSDO

Identifiers

PMID26178205
OpenAlexW2168615516

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.