ArticleAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics2015
Assessment of first and second degree relatives of individuals with bipolar disorder shows increased genetic risk scores in both affected relatives and young At-Risk Individuals.
Article in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Neurocognitive functioning in euthymic patients with bipolar disorder and unaffected relatives: A review of the literature.Neuroscience and biobehavioral reviews · 2016Pooled it
- Polygenic scores for psychiatric traits mediate the impact of multigenerational history for depression on offspring psychopathology.Molecular psychiatry · 2026Article
- Development and validation of a multi-modality system combining radiomics and deep learning for predicting mid-pregnancy complications and enabling timely pregnancy care.Frontiers in pediatrics · 2025Article
- Person-level contributions of bipolar polygenic risk score to the prediction of new-onset bipolar disorder in at-risk offspring.Journal of affective disorders · 2025Article
- Putative Risk Biomarkers of Bipolar Disorder in At-risk Youth.Neuroscience bulletin · 2024Review
- A Plea for Nuance: Should People with a Family History of Bipolar Disorder Be Excluded from Clinical Trials of Psilocybin Therapy?Psychedelic medicine (New Rochelle, N.Y.) · 2024Review
- Genome-wide DNA methylation risk scores for schizophrenia derived from blood and brain tissues further explain the genetic risk in patients stratified by polygenic risk scores for schizophrenia and bipolar disorder.BMJ mental health · 2024Article
- Association of polygenic risk for bipolar disorder with grey matter structure and white matter integrity in youth.Translational psychiatry · 2023Article
- Family environment and polygenic risk in the bipolar high-risk context.JCPP advances · 2023Article
- Barriers to genetic testing in clinical psychiatry and ways to overcome them: from clinicians' attitudes to sociocultural differences between patients across the globe.Translational psychiatry · 2022Review
- Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders.Molecular psychiatry · 2021Article
- Polygenic risk scores of several subtypes of epilepsies in a founder population.Neurology. Genetics · 2020Article
- Contribution of common and rare damaging variants in familial forms of bipolar disorder and phenotypic outcome.Translational psychiatry · 2020Article
- Aberrant structural covariance networks in youth at high familial risk for mood disorder.Bipolar disorders · 2020Article
- Family Clustering of Autoimmune Vitiligo Results Principally from Polygenic Inheritance of Common Risk Alleles.American journal of human genetics · 2019Article
- Characteristics of patients attending the child and adolescent psychiatric outpatient clinic in Erbil city.PloS one · 2019Article
- Polygenic risk scores in psychiatry: Will they be useful for clinicians?F1000Research · 2019Review
- Elevated Familial Cardiovascular Burden Among Adolescents With Familial Bipolar Disorder.Frontiers in psychiatry · 2019Article
- Clinical Practice Guidelines for Bipolar Affective Disorder (BPAD) in Children and Adolescents.Indian journal of psychiatry · 2019Article
- What Should a Psychiatrist Know About Genetics? Review and Recommendations From the Residency Education Committee of the International Society of Psychiatric Genetics.The Journal of clinical psychiatry · 2018Review
Corrections and comments
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Authors and funding
14 authors at 8 institutions in 2 countries.
Funding
Abstract
Recent studies have revealed the polygenic nature of bipolar disorder (BP), and identified common risk variants associated with illness. However, the role of common polygenic risk in multiplex families has not previously been examined. The present study examined 249 European-ancestry families from the NIMH Genetics Initiative sample, comparing subjects with narrowly defined BP (excluding bipolar II and recurrent unipolar depression; n = 601) and their adult relatives without BP (n = 695). Unrelated adult controls (n = 266) were from the NIMH TGEN control dataset. We also examined a prospective cohort of young (12-30 years) offspring and siblings of individuals with BPI and BPII disorder (at risk; n = 367) and psychiatrically screened controls (n = 229), ascertained from five sites in the US and Australia and assessed with standardized clinical protocols. Thirty-two disease-associated SNPs from the PGC-BP Working Group report (2011) were genotyped and additive polygenic risk scores (PRS) derived. We show increased PRS in adult cases compared to unrelated controls (P = 3.4 × 10(-5) , AUC = 0.60). In families with a high-polygenic load (PRS score ≥32 in two or more subjects), PRS distinguished cases with BPI/SAB from other relatives (P = 0.014, RR = 1.32). Secondly, a higher PRS was observed in at-risk youth, regardless of affected status, compared to unrelated controls (GEE-χ(2) = 5.15, P = 0.012). This report is the first to explore common polygenic risk in multiplex families, albeit using only a small number of robustly associated risk variants. We show that individuals with BP have a higher load of common disease-associated variants than unrelated controls and first-degree relatives, and illustrate the potential utility of PRS assessment in a family context.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.