Evidence map›Paper›PMID 26178031›Full record

ReviewAdvances in nutrition (Bethesda, Md.)2015

Obesity and the neurocognitive basis of food reward and the control of intake.

Hisham Ziauddeen, Miguel Alonso-Alonso, James O Hill, Michael Kelley, Naiman A Khan

Abstract readReview
In one paragraph

Review in Advances in nutrition (Bethesda, Md.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Outcomes From a Sequential Multiple Assignment Randomized Trial of Weight Loss Strategies for African American Adolescents With Obesity.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2019
    Trial
  5. Article
  6. Review
  7. Review
  8. Review
  9. GLP-1 receptor agonism: a transformative approach for managing type-2 diabetes and obesity.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2025
    Review
  10. Early Impact of Bariatric Surgery on Brain Functionality.Journal of metabolic and bariatric surgery · 2025
    Review
  11. Article
  12. Article
  13. Perspectives on obesity imaging: [International journal of obesity (2005) · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article

9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hisham ZiauddeenDepartment of Psychiatry, University of Cambridge, Cambridge, United Kingdom; Wellcome Trust-MRC, Institute of Metabolic Science, Cambridge, United Kingdom; Cambridgeshire and Peterborough Foundation Trust, Cambridge, United Kingdom; hz238@cam.ac.uk.ORCID http://orcid.org/0000-0003-4044-1719
Miguel Alonso-AlonsoLaboratory of Bariatric and Nutritional Neuroscience, Center for the Study of Nutrition Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA;
James O HillAnschutz Health and Wellness Center, University of Colorado, Anschutz Medical Campus, Aurora, CO;ORCID http://orcid.org/0000-0003-4690-2264
Michael KelleyScientific and Regulatory Affairs, Wm. Wrigley Jr. Company, Chicago, IL; and.
Naiman A KhanDepartment of Kinesiology and Community Health, University of Illinois, Urbana-Champaign, IL.

Funding

ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Alessio Fasano · 1994 to 2026
$31.6M
NIDDK NIH HHS P30 DK040561
6 · The paper itself

Abstract

With the rising prevalence of obesity, hedonic eating has become an important theme in obesity research. Hedonic eating is thought to be that driven by the reward of food consumption and not metabolic need, and this has focused attention on the brain reward system and how its dysregulation may cause overeating and obesity. Here, we begin by examining the brain reward system and the evidence for its dysregulation in human obesity. We then consider the issue of how individuals are able to control their hedonic eating in the present obesogenic environment and compare 2 contrasting perspectives on the control of hedonic eating, specifically, enhanced control of intake via higher cognitive control and loss of control over intake as captured by the food addiction model. We conclude by considering what these perspectives offer in terms of directions for future research and for potential interventions to improve control over food intake at the population and the individual levels.

Indexed as

Appetite RegulationCognitionFoodRewardBehavior, AddictiveBrainEatingHumansMagnetic Resonance ImagingObesityPhilosophycognitive controleating behaviorfood addictionfood intake and appetite regulationneuroimagingobesity

Identifiers

PMID26178031
PMCPMC4496739

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.