Evidence map›Paper›PMID 26178030›Full record

ReviewAdvances in nutrition (Bethesda, Md.)2015

Dietary advanced glycation end products and their role in health and disease.

Jaime Uribarri, María Dolores del Castillo, María Pía de la Maza, Rosana Filip, Alejandro Gugliucci, Claudia Luevano-Contreras, Maciste H Macías-Cervantes, Deborah H Markowicz Bastos, Alejandra Medrano, Teresita Menini and 6 more

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advances in nutrition (Bethesda, Md.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 150 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
150citing papers in PubMed, 4 pooled it
17.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

150 citing papers in PubMed, 4 syntheses or guidelines pooled it, 352 citations in OpenAlex.

  1. Pooled it
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  4. Protein hydrolysate versus standard formula for preterm infants.The Cochrane database of systematic reviews · 2019
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  12. Association between dietary advanced glycation end products and gallstone disease: A case-control study.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026
    Article
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  18. Dietary Advanced Glycation End Products and Cardiovascular-Kidney-Metabolic Complications.Clinical journal of the American Society of Nephrology : CJASN · 2026
    Review
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  20. Article

90 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 10 institutions in 7 countries.

Jaime UribarriDepartment of Medicine, The Icahn School of Medicine at Mount Sinai, New York, NY; Jaime.uribarri@mssm.edu.
María Dolores del CastilloFood Bioscience Group, Department of Food Analysis and Bioactivity, Institute of Food Science Research, Spanish National Research Council, Madrid, Spain;
María Pía de la MazaInstitute of Nutrition and Food Technology Dr. Fernando Monckeberg Barros, University of Chile, Santiago, Chile;
Rosana FilipDepartment of Pharmacognosy, Institute of Drug Chemistry and Metabolism, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina;
Alejandro GugliucciCollege of Osteopathic Medicine, Touro University California, Vallejo, CA;
Claudia Luevano-ContrerasMedical Science Department, University of Guanajuato, Guanajuato, Mexico;
Maciste H Macías-CervantesMedical Science Department, University of Guanajuato, Guanajuato, Mexico;
Deborah H Markowicz BastosNutrition Department, School of Public Health, São Paulo University, São Paulo, Brazil;
Alejandra MedranoFood Science and Technology Department, School of Chemistry, University of the Republic, Montevideo, Uruguay;
Teresita MeniniCollege of Osteopathic Medicine, Touro University California, Vallejo, CA;
Manuel Portero-OtinMetabolic Pathophysiology Department, School of Medicine, Biomedical Research Institute of Lleida, University of Lleida, Lleida, Spain;
Armando RojasBiomedical Research Laboratories, Faculty of Medicine, Catholic University of Maule, Talca, Chile; and.
Geni Rodrigues SampaioNutrition Department, School of Public Health, São Paulo University, São Paulo, Brazil;
Kazimierz WrobelChemistry Department, University of Guanajuato, Guanajuato, Mexico.
Katarzyna WrobelChemistry Department, University of Guanajuato, Guanajuato, Mexico.
Ma Eugenia Garay-SevillaMedical Science Department, University of Guanajuato, Guanajuato, Mexico;
Universidad de Guanajuato · MXTouro University California · USUniversidade de São Paulo · BRCatholic University of America · USConsejo Superior de Investigaciones Científicas · ESIcahn School of Medicine at Mount Sinai · USUniversidad de la República · UYUniversitat de Lleida · ESUniversity of Buenos Aires · ARUniversity of Chile · CL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Over the past 2 decades there has been increasing evidence supporting an important contribution from food-derived advanced glycation end products (AGEs) to the body pool of AGEs and therefore increased oxidative stress and inflammation, processes that play a major role in the causation of chronic diseases. A 3-d symposium (1st Latin American Symposium of AGEs) to discuss this subject took place in Guanajuato, Mexico, on 1-3 October 2014 with the participation of researchers from several countries. This review is a summary of the different presentations and subjects discussed, and it is divided into 4 sections. The first section deals with current general knowledge about AGEs. The second section dwells on mechanisms of action of AGEs, with special emphasis on the receptor for advanced glycation end products and the potential role of AGEs in neurodegenerative diseases. The third section discusses different approaches to decrease the AGE burden. The last section discusses current methodologic problems with measurement of AGEs in different samples. The subject under discussion is complex and extensive and cannot be completely covered in a short review. Therefore, some areas of interest have been left out because of space. However, we hope this review illustrates currently known facts about dietary AGEs as well as pointing out areas that require further research.

Indexed as

Chronic DiseaseDietGlycation End Products, AdvancedHealth StatusAgricultureCookingExerciseFoodFood HandlingHot TemperatureHumansInflammationLysineMexicoNeurodegenerative DiseasesOxidative StressGlycation End Products, AdvancedLysineN(6)-carboxymethyllysineReceptor for Advanced Glycation End Productsinflammationinsulin resistancenutraceuticalnutritionoxidative stressRAGE

Identifiers

PMID26178030
PMCPMC4496742
OpenAlexW1867132694

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.