ArticleJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance2015
Magnetic susceptibility anisotropy of myocardium imaged by cardiovascular magnetic resonance reflects the anisotropy of myocardial filament α-helix polypeptide bonds.
Article in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 38 citations in OpenAlex.
- Quantitative susceptibility mapping (QSM) of the cardiovascular system: challenges and perspectives.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2022Review
- Quantitative susceptibility mapping of the head-and-neck using SMURF fat-water imaging with chemical shift and relaxation rate corrections.Magnetic resonance in medicine · 2022Article
- Asymmetric susceptibility tensor imaging.Magnetic resonance in medicine · 2021Article
- Ultrashort echo time quantitative susceptibility mapping (UTE-QSM) for detection of hemosiderin deposition in hemophilic arthropathy: A feasibility study.Magnetic resonance in medicine · 2020Article
- Learning-based single-step quantitative susceptibility mapping reconstruction without brain extraction.NeuroImage · 2019Article
- Quantifying MRI frequency shifts due to structures with anisotropic magnetic susceptibility using pyrolytic graphite sheet.Scientific reports · 2018Article
- Quantitative susceptibility mapping: Report from the 2016 reconstruction challenge.Magnetic resonance in medicine · 2018Article
- Cardiac quantitative susceptibility mapping (QSM) for heart chamber oxygenation.Magnetic resonance in medicine · 2018Article
- Review of Journal of Cardiovascular Magnetic Resonance (JCMR) 2015-2016 and transition of the JCMR office to Boston.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2017Review
- Susceptibility tensor imaging and tractography of collagen fibrils in the articular cartilage.Magnetic resonance in medicine · 2017Article
- Investigating magnetic susceptibility of human knee joint at 7 Tesla.Magnetic resonance in medicine · 2017Article
- Temperature-activated ion channels in neural crest cells confer maternal fever-associated birth defects.Science signaling · 2017Article
- Joint eigenvector estimation from mutually anisotropic tensors improves susceptibility tensor imaging of the brain, kidney, and heart.Magnetic resonance in medicine · 2017Article
- Magnetic susceptibility anisotropy outside the central nervous system.NMR in biomedicine · 2017Review
- MRI tools for assessment of microstructure and nephron function of the kidney.American journal of physiology. Renal physiology · 2016Review
- Review of Journal of Cardiovascular Magnetic Resonance 2015.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2016Review
- Quantitative Susceptibility Mapping: Contrast Mechanisms and Clinical Applications.Tomography (Ann Arbor, Mich.) · 2015Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundA key component of evaluating myocardial tissue function is the assessment of myofiber organization and structure. Studies suggest that striated muscle fibers are magnetically anisotropic, which, if measurable in the heart, may provide a tool to assess myocardial microstructure and function.
methodsTo determine whether this weak anisotropy is observable and spatially quantifiable with cardiovascular magnetic resonance (CMR), both gradient-echo and diffusion-weighted data were collected from intact mouse heart specimens at 9.4 Tesla. Susceptibility anisotropy was experimentally calculated using a voxelwise analysis of myocardial tissue susceptibility as a function of myofiber angle. A myocardial tissue simulation was developed to evaluate the role of the known diamagnetic anisotropy of the peptide bond in the observed susceptibility contrast.
resultsThe CMR data revealed that myocardial tissue fibers that were parallel and perpendicular to the magnetic field direction appeared relatively paramagnetic and diamagnetic, respectively. A linear relationship was found between the magnetic susceptibility of the myocardial tissue and the squared sine of the myofiber angle with respect to the field direction. The multi-filament model simulation yielded susceptibility anisotropy values that reflected those found in the experimental data, and were consistent that this anisotropy decreased as the echo time increased.
conclusionsThough other sources of susceptibility anisotropy in myocardium may exist, the arrangement of peptide bonds in the myofilaments is a significant, and likely the most dominant source of susceptibility anisotropy. This anisotropy can be further exploited to probe the integrity and organization of myofibers in both healthy and diseased heart tissue.
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