ArticleBMC medical genomics2015
Integrated sequence and expression analysis of ovarian cancer structural variants underscores the importance of gene fusion regulation.
Article in BMC medical genomics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- De novo assembly and characterization of breast cancer transcriptomes identifies large numbers of novel fusion-gene transcripts of potential functional significance.BMC medical genomics · 2017Article
- Genomic analysis of oesophageal squamous-cell carcinoma identifies alcohol drinking-related mutation signature and genomic alterations.Nature communications · 2017Article
- Intrinsically disordered proteins and prostate cancer: pouring new wine in an old bottle.Asian journal of andrologyArticle
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2 authors.
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Abstract
backgroundGenomic rearrangements or structural variants (SVs) are one of the most common classes of mutations in cancer.
methodsAn integrated DNA sequencing and transcriptional profiling (RNA sequence and microarray gene expression data) analysis was performed on six ovarian cancer patient samples. Matched sets of control (whole blood) samples from these same patients were used to distinguish cancer SVs of germline origin from those arising somatically in the cancer cell lineage.
resultsWe detected 10,034 ovarian cancer SVs (5518 germline derived; 4516 somatically derived) at base-pair level resolution. Only 11 % of these variants were shown to have the potential to form gene fusions and, of these, less than 20 % were detected at the transcriptional level.
conclusionsCollectively our results are consistent with the view that gene fusions and other SVs can be significant factors in the onset and progression of ovarian cancer. The results further indicate that it may not only be the occurrence of these variants in cancer but their regulation that contributes to their biological and clinical significance.
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