Evidence map›Paper›PMID 26177553›Full record

ArticleGynecologic oncology2015

Consensus in controversy: The modified Delphi method applied to Gynecologic Oncology practice.

David E Cohn, Laura J Havrilesky, Kathryn Osann, Joseph Lipscomb, Susie Hsieh, Joan L Walker, Alexi A Wright, Ronald D Alvarez, Beth Y Karlan, Robert E Bristow and 5 more

Abstract read
In one paragraph

Article in Gynecologic oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

David E CohnThe Ohio State University, Columbus, OH, United States. Electronic address: david.cohn@osumc.edu.
Laura J HavrileskyDuke University School of Medicine, Durham, NC, United States.
Kathryn OsannUniversity of California at Irvine, Irvine, CA, United States.
Joseph LipscombEmory University Rollins School of Public Health and Winship Cancer Institute, Atlanta, GA, United States.
Susie HsiehUniversity of California at Irvine, Irvine, CA, United States.
Joan L WalkerThe University of Oklahoma, Oklahoma City, OK, United States.
Alexi A WrightDana-Farber Cancer Institute/Harvard Medical School, Boston, MA, United States.
Ronald D AlvarezUniversity of Alabama at Birmingham, Birmingham, AL, United States.
Beth Y KarlanCedars Sinai Medical Center, Los Angeles, CA, United States.
Robert E BristowUniversity of California at Irvine, Irvine, CA, United States.
Paul A DiSilvestroWomen & Infants Hospital, Brown University, Providence, RI, United States.
Mark T WakabayashiCity of Hope, Duarte, CA, United States.
Robert MorganCity of Hope, Duarte, CA, United States.
Dana B MukamelUniversity of California Irvine, School of Medicine, Orange, CA, United States.
Lari WenzelUniversity of California at Irvine, Irvine, CA, United States.

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Christine Hui · 1994 to 2026
$57.9M
Chemotherapy Near Death: Modifiable Factors and Outcomes in Ovarian CancerK07CA166210 · NCI · DANA-FARBER CANCER INST · PI WRIGHT, ALEXI A · 2013 to 2017
$886k
NCI NIH HHS K07 CA166210NCI NIH HHS P30 CA062203
6 · The paper itself

Abstract

objectivesTo determine the degree of consensus regarding the probabilities of outcomes associated with IP/IV and IV chemotherapy.

methodsA survey was administered to an expert panel using the Delphi method. Ten ovarian cancer experts were asked to estimate outcomes for patients receiving IP/IV or IV chemotherapy. The clinical estimates were: 1) probability of completing six cycles of chemotherapy, 2) probability of surviving five years, 3) median survival, and 4) probability of ER/hospital visits during treatment. Estimates for two patients, one with a low comorbidity index (patient 1) and the other with a moderate index (patient 2), were included. The survey was administered in three rounds, and panelists could revise their subsequent responses based on review of the anonymous opinions of their peers.

resultsThe ranges were smaller for IV compared with IP/IV therapy. Ranges decreased with each round. Consensus converged around outcomes related to IP/IV chemotherapy for: 1) completion of 6 cycles of therapy (type 1 patient, 62%, type 2 patient, 43%); 2) percentage of patients surviving 5 years (type 1 patient, 66%, type 2 patient, 47%); and 3) median survival (type 1 patient, 83 months, type 2 patient, 58 months). The group required three rounds to achieve consensus on the probabilities of ER/hospital visits (type 1 patient, 24%, type 2 patient, 35%).

conclusionsInitial estimates of survival and adverse events associated with IP/IV chemotherapy differ among experts. The Delphi process works to build consensus and may be a pragmatic tool to inform patients of their expected outcomes.

Indexed as

ConsensusDelphi TechniqueFemaleHumansOvarian NeoplasmsDelphi techniqueIntraperitoneal (IP)OpinionOvarian cancer

Identifiers

PMID26177553
PMCPMC4920477

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.